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BAVACHIN

Product Name
BAVACHIN
CAS No.
19879-32-4
Chemical Name
BAVACHIN
Synonyms
BAVACHIN;Bavachin-RM;Bavachin, 10 mM in DMSO;Bavachin from Psoralea coryfolia, >=97% (HPLC);(S)-7-Hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one;7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;(2S)-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;(S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;(2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-, (2S)-
CBNumber
CB01433061
Molecular Formula
C20H20O4
Formula Weight
324.37
MOL File
19879-32-4.mol
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BAVACHIN Property

Boiling point:
558.3±50.0 °C(Predicted)
Density 
1.244
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
≤20mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form 
crystalline solid
pka
8.27±0.40(Predicted)
color 
White
InChI
InChI=1S/C20H20O4/c1-12(2)3-4-14-9-16-18(23)11-19(24-20(16)10-17(14)22)13-5-7-15(21)8-6-13/h3,5-10,19,21-22H,4,11H2,1-2H3/t19-/m0/s1
InChIKey
OAUREGNZECGNQS-IBGZPJMESA-N
SMILES
[C@H]1(C2=CC=C(O)C=C2)OC2=CC(O)=C(C/C=C(/C)\C)C=C2C(=O)C1
CAS DataBase Reference
19879-32-4
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11685
Product name
Bavachin
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
11685
Product name
Bavachin
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
11685
Product name
Bavachin
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
TRC
Product number
B129200
Product name
Bavachin
Packaging
50mg
Price
$130
Updated
2021/12/16
Usbiological
Product number
299987
Product name
Bavachin
Packaging
20mg
Price
$470
Updated
2021/12/16
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BAVACHIN Chemical Properties,Usage,Production

Description

Bavachin is a flavonoid first isolated from seeds of P. corylifolia. It is a phytoestrogen that activates the estrogen receptors ERα and ERβ (EC50s = 320 and 680 nM, respectively). Through this action, bavachin stimulates osteoblast proliferation and differentiation and prevents bone loss following ovariectomy in rats. Bavachin less potently inhibits acyl-coenzyme A:cholesterol acyltransferase (IC50 = 86 μM).

Chemical Properties

Pale yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the fruit of Psoralea corylifolia Linn.

Uses

Bavachin has therapeutic potential for type 2 diabetes by activating insulin signaling pathways. Also, it has anabolic and potent anticatabolic biological effects on chondrocytes. Strong inhibitor of human UDP-glucuronosyltransferase (UGT1A1)

target

NF-kB | p65 | IkB | VEGFR | IL Receptor | AP-1 | AMPK | PPAR | GLUT | Akt | IKK | Estrogen receptor α | Estrogen receptor β

References

[1] choi j h, rho m c, lee s w, et al. bavachin and isobavachalcone, acyl-coenzyme a: cholesterol acyltransferase inhibitors from psoralea corylifolia[j]. archives of pharmacal research, 2008, 31(11): 1419-1423.
[2] park j, kim d h, ahn h n, et al. activation of estrogen receptor by bavachin from psoralea corylifolia[j]. biomolecules & therapeutics, 2012, 20(2): 183-188.
[3] lee h, li h, noh m, et al. bavachin from psoralea corylifolia improves insulin-dependent glucose uptake through insulin signaling and ampk activation in 3t3-l1 adipocytes[j]. international journal of molecular sciences, 2016, 17(4): 527.

BAVACHIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BAVACHIN Suppliers

China 206 India 1 United Kingdom 1 United States 12 Global 220
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
Shanghai Moqi Biological Technology Co., LTD
Tel
021-38218169 13681877033
Email
2702713455@qq.com
Country
China
ProdList
9997
Advantage
58
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Shanghai Winherb Medical Technology Co., Ltd.
Tel
021-38218169 13341702378
Fax
QQ：190129269
Email
winherb@126.com
Country
China
ProdList
1245
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
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View Lastest Price from BAVACHIN manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
BAVACHIN 19879-32-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2025-03-14
Shanghai Standard Technology Co., Ltd.
Product
Bavachin 19879-32-4
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-23
Career Henan Chemical Co
Product
BAVACHIN 19879-32-4
Price
US $120.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
customise
Release date
2018-07-26

19879-32-4, BAVACHINRelated Search:

tuberostemonine Bilobalide Mangostin Curcumol 3-O-alpha-L-Arabinopyranosylhederagenin 28-O-alpha-L-rhamnopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl ester 8-Methoxypsoralen Hederagenin 28-O-beta-D-glucopyranosyl ester 8-Methyl Chrysophanol MAGNOFLORINE IODIDE, (+)-(RG) Acetytastragaloside 3''-PRENYLDAIDZEIN 8-SHOGAOL α-Hederin Psoralenoside Isopsoralenoside kalopanax saponin H BAVACHININ A Bavachalcone

  • BAVACHIN
  • (S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
  • (2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
  • 7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-, (2S)-
  • Bavachin from Psoralea coryfolia, >=97% (HPLC)
  • (2S)-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
  • (S)-7-Hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one
  • Bavachin-RM
  • Bavachin, 10 mM in DMSO
  • 19879-32-4