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BAVACHIN

Product Name
BAVACHIN
CAS No.
19879-32-4
Chemical Name
BAVACHIN
Synonyms
BAVACHIN;Bavachin-RM;Bavachin, 10 mM in DMSO;Bavachin from Psoralea coryfolia, >=97% (HPLC);(S)-7-Hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one;7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;(2S)-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;(S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;(2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-, (2S)-
CBNumber
CB01433061
Molecular Formula
C20H20O4
Formula Weight
324.37
MOL File
19879-32-4.mol
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BAVACHIN Property

Boiling point:
558.3±50.0 °C(Predicted)
Density 
1.244
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
≤20mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form 
crystalline solid
pka
8.27±0.40(Predicted)
color 
White
InChI
InChI=1S/C20H20O4/c1-12(2)3-4-14-9-16-18(23)11-19(24-20(16)10-17(14)22)13-5-7-15(21)8-6-13/h3,5-10,19,21-22H,4,11H2,1-2H3/t19-/m0/s1
InChIKey
OAUREGNZECGNQS-IBGZPJMESA-N
SMILES
[C@H]1(C2=CC=C(O)C=C2)OC2=CC(O)=C(C/C=C(/C)\C)C=C2C(=O)C1
CAS DataBase Reference
19879-32-4
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11685
Product name
Bavachin
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
11685
Product name
Bavachin
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
11685
Product name
Bavachin
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
TRC
Product number
B129200
Product name
Bavachin
Packaging
50mg
Price
$130
Updated
2021/12/16
Usbiological
Product number
299987
Product name
Bavachin
Packaging
20mg
Price
$470
Updated
2021/12/16
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BAVACHIN Chemical Properties,Usage,Production

Description

Bavachin is a flavonoid first isolated from seeds of P. corylifolia. It is a phytoestrogen that activates the estrogen receptors ERα and ERβ (EC50s = 320 and 680 nM, respectively). Through this action, bavachin stimulates osteoblast proliferation and differentiation and prevents bone loss following ovariectomy in rats. Bavachin less potently inhibits acyl-coenzyme A:cholesterol acyltransferase (IC50 = 86 μM).

Chemical Properties

Pale yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the fruit of Psoralea corylifolia Linn.

Uses

Bavachin has therapeutic potential for type 2 diabetes by activating insulin signaling pathways. Also, it has anabolic and potent anticatabolic biological effects on chondrocytes. Strong inhibitor of human UDP-glucuronosyltransferase (UGT1A1)

target

NF-kB | p65 | IkB | VEGFR | IL Receptor | AP-1 | AMPK | PPAR | GLUT | Akt | IKK | Estrogen receptor α | Estrogen receptor β

References

[1] choi j h, rho m c, lee s w, et al. bavachin and isobavachalcone, acyl-coenzyme a: cholesterol acyltransferase inhibitors from psoralea corylifolia[j]. archives of pharmacal research, 2008, 31(11): 1419-1423.
[2] park j, kim d h, ahn h n, et al. activation of estrogen receptor by bavachin from psoralea corylifolia[j]. biomolecules & therapeutics, 2012, 20(2): 183-188.
[3] lee h, li h, noh m, et al. bavachin from psoralea corylifolia improves insulin-dependent glucose uptake through insulin signaling and ampk activation in 3t3-l1 adipocytes[j]. international journal of molecular sciences, 2016, 17(4): 527.

BAVACHIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BAVACHIN manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
BAVACHIN 19879-32-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2025-03-14
Shanghai Standard Technology Co., Ltd.
Product
Bavachin 19879-32-4
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-23
Career Henan Chemical Co
Product
BAVACHIN 19879-32-4
Price
US $120.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
customise
Release date
2018-07-26

19879-32-4, BAVACHINRelated Search:

tuberostemonine Bilobalide Mangostin Curcumol 3-O-alpha-L-Arabinopyranosylhederagenin 28-O-alpha-L-rhamnopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl ester 8-Methoxypsoralen Hederagenin 28-O-beta-D-glucopyranosyl ester 8-Methyl Chrysophanol MAGNOFLORINE IODIDE, (+)-(RG) Acetytastragaloside 3''-PRENYLDAIDZEIN 8-SHOGAOL α-Hederin Psoralenoside Isopsoralenoside kalopanax saponin H BAVACHININ A Bavachalcone

  • BAVACHIN
  • (S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
  • (2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
  • 7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-, (2S)-
  • Bavachin from Psoralea coryfolia, >=97% (HPLC)
  • (2S)-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
  • (S)-7-Hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one
  • Bavachin-RM
  • Bavachin, 10 mM in DMSO
  • 19879-32-4