ChemicalBook > CAS DataBase List > BAVACHIN

BAVACHIN

Product Name
BAVACHIN
CAS No.
19879-32-4
Chemical Name
BAVACHIN
Synonyms
BAVACHIN;Bavachin-RM;Bavachin from Psoralea coryfolia, >=97% (HPLC);(S)-7-Hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one;7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;(2S)-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;(S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;(2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-, (2S)-
CBNumber
CB01433061
Molecular Formula
C20H20O4
Formula Weight
324.37
MOL File
19879-32-4.mol
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BAVACHIN Property

Boiling point:
558.3±50.0 °C(Predicted)
Density 
1.244
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
≤20mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form 
crystalline solid
pka
8.27±0.40(Predicted)
color 
White
CAS DataBase Reference
19879-32-4
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11685
Product name
Bavachin
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
11685
Product name
Bavachin
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
11685
Product name
Bavachin
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
TRC
Product number
B129200
Product name
Bavachin
Packaging
50mg
Price
$130
Updated
2021/12/16
Usbiological
Product number
299987
Product name
Bavachin
Packaging
20mg
Price
$470
Updated
2021/12/16
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BAVACHIN Chemical Properties,Usage,Production

Description

Bavachin is a flavonoid first isolated from seeds of P. corylifolia. It is a phytoestrogen that activates the estrogen receptors ERα and ERβ (EC50s = 320 and 680 nM, respectively). Through this action, bavachin stimulates osteoblast proliferation and differentiation and prevents bone loss following ovariectomy in rats. Bavachin less potently inhibits acyl-coenzyme A:cholesterol acyltransferase (IC50 = 86 μM).

Uses

Bavachin has therapeutic potential for type 2 diabetes by activating insulin signaling pathways. Also, it has anabolic and potent anticatabolic biological effects on chondrocytes. Strong inhibitor of human UDP-glucuronosyltransferase (UGT1A1)

target

NF-kB | p65 | IkB | VEGFR | IL Receptor | AP-1 | AMPK | PPAR | GLUT | Akt | IKK | Estrogen receptor α | Estrogen receptor β

References

[1] choi j h, rho m c, lee s w, et al. bavachin and isobavachalcone, acyl-coenzyme a: cholesterol acyltransferase inhibitors from psoralea corylifolia[j]. archives of pharmacal research, 2008, 31(11): 1419-1423.
[2] park j, kim d h, ahn h n, et al. activation of estrogen receptor by bavachin from psoralea corylifolia[j]. biomolecules & therapeutics, 2012, 20(2): 183-188.
[3] lee h, li h, noh m, et al. bavachin from psoralea corylifolia improves insulin-dependent glucose uptake through insulin signaling and ampk activation in 3t3-l1 adipocytes[j]. international journal of molecular sciences, 2016, 17(4): 527.

BAVACHIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BAVACHIN manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
BAVACHIN 19879-32-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2022-10-28
Hebei Mojin Biotechnology Co., Ltd
Product
BAVACHIN 19879-32-4
Price
US $50.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20tons
Release date
2023-08-17
Shanghai Standard Technology Co., Ltd.
Product
Bavachin 19879-32-4
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-23

19879-32-4, BAVACHINRelated Search:

tuberostemonine Bilobalide Mangostin Curcumol 3-O-alpha-L-Arabinopyranosylhederagenin 28-O-alpha-L-rhamnopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl ester 8-Methoxypsoralen Hederagenin 28-O-beta-D-glucopyranosyl ester 8-Methyl Chrysophanol MAGNOFLORINE IODIDE, (+)-(RG) Acetytastragaloside 3''-PRENYLDAIDZEIN 8-SHOGAOL α-Hederin Psoralenoside Isopsoralenoside kalopanax saponin H BAVACHININ A Bavachalcone

  • BAVACHIN
  • (S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
  • (2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
  • 7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-, (2S)-
  • Bavachin from Psoralea coryfolia, >=97% (HPLC)
  • (2S)-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
  • (S)-7-Hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one
  • Bavachin-RM
  • 19879-32-4