ChemicalBook > CAS DataBase List > D609

D609

Product Name
D609
CAS No.
83373-60-8
Chemical Name
D609
Synonyms
D609;D609 ,98%;D609,D-609;D-609 POTASSIUM;D609 POTASSIUM SALT;D609, 10 mM in DMSO;D609 potassium salt,98%;Tricyclodecan-9-yl xanthate;Tricyclodecan-9-yl xanthogenate;tricyclodecane-9-yl-xanthogenate
CBNumber
CB9249743
Molecular Formula
C11H17KOS2
Formula Weight
268.47
MOL File
83373-60-8.mol
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D609 Property

storage temp. 
0-6°C
solubility 
H2O: 300 mg/mL
form 
solid
color 
off-white
biological source
synthetic (organic)
Water Solubility 
Soluble to 100 mM in water
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Safety

Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
3
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T8543
Product name
O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt
Purity
≥95%, solid
Packaging
5mg
Price
$266
Updated
2025/07/31
Sigma-Aldrich
Product number
251400
Product name
D609, Potassium Salt
Packaging
5mg
Price
$297
Updated
2025/07/31
Cayman Chemical
Product number
13307
Product name
D609 (potassium salt)
Purity
≥90%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
13307
Product name
D609 (potassium salt)
Purity
≥90%
Packaging
5mg
Price
$81
Updated
2024/03/01
Sigma-Aldrich
Product number
T8543
Product name
O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt
Purity
≥95%, solid
Packaging
25mg
Price
$1070
Updated
2025/07/31
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D609 Chemical Properties,Usage,Production

Description

D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; Ki = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.

Chemical Properties

white to off-white solid

Uses

D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E-/- mice.

Biological Activity

Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K i = 6.4 μ M); antiviral and antitumor agent. Suppresses LPS- and IFN γ -induced NO production (IC 50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo .

Biochem/physiol Actions

D609 can block the production of diacylglycerol (DAG) in the cell. D609 functions by inhibiting the phospholipase C-mediated hydrolysis of the phosphate bond present in phosphatidylcholine and other glycerophospholipids.

storage

Desiccate at -20°C

References

1. a) e. amtmann, drugs exp clin res 1996, 22, 287-294; b) r. m. adibhatla, j. f. hatcher and a. gusain, neurochem res 2012, 37, 671-679. 2. l. paris, s. cecchetti, f. spadaro, l. abalsamo, l. lugini, m. e. pisanu, e. iorio, p. g. natali, c. ramoni and f. podo, breast cancer res 2010, 12, r27. 3. a) k. tschaikowsky, m. meisner, f. schonhuber and e. rugheimer, br j pharmacol 1994, 113, 664-668; b) r. r. cobb, k. a. felts, g. c. parry and n. mackman, mol pharmacol 1996, 49, 998-1004.

D609 Preparation Products And Raw materials

Raw materials

Preparation Products

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D609 Suppliers

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83373-60-8, D609Related Search:

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  • 83373-60-8
  • C11H15KOS2
  • Biochemicals and Reagents
  • BioChemical
  • P to Q
  • Phospholipase C, phosphatidylcholine-specific
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Lipid signaling