D609
- Product Name
- D609
- CAS No.
- 83373-60-8
- Chemical Name
- D609
- Synonyms
- D609;D609 ,98%;D609,D-609;D-609 POTASSIUM;D609 POTASSIUM SALT;D609 potassium salt,98%;Tricyclodecan-9-yl xanthate;Tricyclodecan-9-yl xanthogenate;tricyclodecane-9-yl-xanthogenate;TRICYCLODECAN-9-YL XANTHOGENATE K
- CBNumber
- CB9249743
- Molecular Formula
- C11H17KOS2
- Formula Weight
- 268.47
- MOL File
- 83373-60-8.mol
D609 Property
- storage temp.
- 0-6°C
- solubility
- H2O: 300 mg/mL
- form
- solid
- color
- off-white
- Water Solubility
- Soluble to 100 mM in water
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T8543
- Product name
- O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt
- Purity
- ≥95%, solid
- Packaging
- 5mg
- Price
- $259
- Updated
- 2024/03/01
- Product number
- 251400
- Product name
- D609, Potassium Salt
- Packaging
- 5mg
- Price
- $289
- Updated
- 2024/03/01
- Product number
- 13307
- Product name
- D609 (potassium salt)
- Purity
- ≥90%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 13307
- Product name
- D609 (potassium salt)
- Purity
- ≥90%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- T8543
- Product name
- O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt
- Purity
- ≥95%, solid
- Packaging
- 25mg
- Price
- $1040
- Updated
- 2024/03/01
D609 Chemical Properties,Usage,Production
Description
D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; Ki = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.
Chemical Properties
white to off-white solid
Uses
D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E-/- mice.
Biological Activity
Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K i = 6.4 μ M); antiviral and antitumor agent. Suppresses LPS- and IFN γ -induced NO production (IC 50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo .
Biochem/physiol Actions
D609 can block the production of diacylglycerol (DAG) in the cell. D609 functions by inhibiting the phospholipase C-mediated hydrolysis of the phosphate bond present in phosphatidylcholine and other glycerophospholipids.
storage
Desiccate at -20°C
References
1. a) e. amtmann, drugs exp clin res 1996, 22, 287-294; b) r. m. adibhatla, j. f. hatcher and a. gusain, neurochem res 2012, 37, 671-679. 2. l. paris, s. cecchetti, f. spadaro, l. abalsamo, l. lugini, m. e. pisanu, e. iorio, p. g. natali, c. ramoni and f. podo, breast cancer res 2010, 12, r27. 3. a) k. tschaikowsky, m. meisner, f. schonhuber and e. rugheimer, br j pharmacol 1994, 113, 664-668; b) r. r. cobb, k. a. felts, g. c. parry and n. mackman, mol pharmacol 1996, 49, 998-1004.