Gilenia

Product Name: Gilenia
CAS No.: 162359-55-9
Chemical Name: Gilenia
Synonyms: Gilenia;Fingomod;Fingolise;fingolimo;fenogliMod;Fingolimod;FingoliMod-D4;FingoliMod Base;Gilenia USP/EP/BP;Fingolimod(FTY720)
CBNumber: CB92498299
Molecular Formula: C19H33NO2
Formula Weight: 307.47
MOL File: 162359-55-9.mol

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Gilenia Property

Melting point:: 103-105°
Boiling point:: 479.5±45.0 °C(Predicted)
Density: 1.016
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Very Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly,
pka: 12.20±0.20(Predicted)
form: Solid
color: Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H402Harmful to aquatic life

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11975
Product name: Fingolimod
Purity: ≥98%
Packaging: 5mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 11975
Product name: Fingolimod
Purity: ≥98%
Packaging: 10mg
Price: $105
Updated: 2024/03/01

Cayman Chemical

Product number: 11975
Product name: Fingolimod
Purity: ≥98%
Packaging: 25mg
Price: $241
Updated: 2024/03/01

Cayman Chemical

Product number: 11975
Product name: Fingolimod
Purity: ≥98%
Packaging: 50mg
Price: $429
Updated: 2024/03/01

TRC

Product number: F342045
Product name: Fingolimod
Packaging: 25mg
Price: $170
Updated: 2021/12/16

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Gilenia Chemical Properties,Usage,Production

Chemical Properties

white solid

Uses

Prophylaxis of organ rejection in patients receiving allogenic renal transplants (sphingosine-1-phosphate receptor).

Uses

Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.

Definition

ChEBI: An aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimo is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate.

Clinical Use

Sphingosine 1-phosphate receptor modulator:
Treatment of highly active relapsing-remitting multiple sclerosis

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: possible increased risk of bradycardia with amiodarone, disopyramide and dronedarone.
Antifungals: concentration increased by ketoconazole.
Beta-blockers: possibly increased risk of bradycardia.
Calcium channel blockers: possible increased risk of bradycardia with diltiazem and verapamil.

Metabolism

Transformed by reversible stereoselective phosphorylation to the pharmacologically active (S)-enantiomer of fingolimod phosphate. It is eliminated by oxidative biotransformation mainly via the cytochrome P450 4F2 isoenzyme and subsequent fatty acid-like degradation to inactive metabolites, and by formation of pharmacologically inactive non-polar ceramide analogues of fingolimod. The main enzyme involved in the metabolism of fingolimod is partially identified and may be either CYP4F2 or CYP3A4. 81% excreted as inactive metabolites in the urine and <2.5% in the faeces as metabolites and unchanged drug.

Gilenia Preparation Products And Raw materials

Raw materials

Preparation Products

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Gilenia Suppliers

Australia 1 China 150 India 15 United Kingdom 1 United States 11 Global 178

Hefei HomeSunshine Pharmaceutical Technology Co., Ltd.

Tel: 0551-65523315 17705606359
Fax: 0551-65523375
Email: errol@homesunshinepharma.com
Country: China
ProdList: 71
Advantage: 58

Nanjing Chemipioneer Pharma& Tech Co., LTD

Tel: 025-52643182 13914798241
Fax: 025-52643182
Email: zhoulq@chemipioneer.com.cn
Country: China
ProdList: 80
Advantage: 62

ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: sales@zhiwe.net
Country: China
ProdList: 627
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2988
Advantage: 65

Suzhou Zehou Biotechnology Co. , Ltd.

Tel: 0512-68716880 19984816880
Fax: 18075373931
Email: sales@growingchem.com
Country: China
ProdList: 194
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19179
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

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View Lastest Price from Gilenia manufacturers

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Product: Gilenia 162359-55-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500MT/month
Release date: 2022-01-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: Gilenia 162359-55-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Gilenia 162359-55-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

162359-55-9, GileniaRelated Search:

Fingolimod EP Impurity D Fingolimod Palmitate Amide Fingolimod Impurity 4 Benzene, 1-(2-iodoethyl)-4-octyl- Fingolimod-d4 2-DiMethylaMino FingoliMod FTY720-d4 Hydrochloride diethyl 2-acetamido-2-(4-octylphenethyl)malonate 2-(4-OCTYLPHENYL)ETHANOL Fingolimod Fingolimod 2-Phenethyl Analog 2-NitrodeaMino FingoliMod 2-(Acetylamino)-2-[2-(4-octylphenyl)-2-oxoethyl]-propanedioic acid 1,3-diethyl ester N-(1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl)butan-2-yl)acetamide DIMETHYL 2-(HYDROXYIMINO)MALONATE Fingolimod 3-Phenethyl Analog Fingolimod Impurity 42 Fingolimod hydrochloride

2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol

Fingolimod(FTY720)

Gilenia

Fingolimod

2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propandiol

FingoliMod Base

fenogliMod

1,3-Propanediol,2-aMino-2-[2-(4-octylphenyl)ethyl]-

Fingolise

FingoliMod-D4

Gilenia, Fingolimod

Gilenya(Fingolise)

2-amino-2-(4-octylphenethyl)propane-1,3-diol

fingolimo

Gilenia USP/EP/BP

FingolimodQ: What is Fingolimod Q: What is the CAS Number of Fingolimod Q: What is the storage condition of Fingolimod Q: What are the applications of Fingolimod

Fingolimod (FTY720 free base)

Fingomod

162359-55-9

pharmaceutical intermediate

API