Gilenia
- Product Name
- Gilenia
- CAS No.
- 162359-55-9
- Chemical Name
- Gilenia
- Synonyms
- Gilenia;Fingolise;fingolimo;fenogliMod;Fingolimod;FingoliMod-D4;FingoliMod Base;Gilenia USP/EP/BP;Fingolimod(FTY720);Gilenya(Fingolise)
- CBNumber
- CB92498299
- Molecular Formula
- C19H33NO2
- Formula Weight
- 307.47
- MOL File
- 162359-55-9.mol
Gilenia Property
- Melting point:
- 103-105°
- Boiling point:
- 479.5±45.0 °C(Predicted)
- Density
- 1.016
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Very Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly,
- pka
- 12.20±0.20(Predicted)
- form
- Solid
- color
- Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H402Harmful to aquatic life
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 11975
- Product name
- Fingolimod
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 11975
- Product name
- Fingolimod
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- 11975
- Product name
- Fingolimod
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $241
- Updated
- 2024/03/01
- Product number
- 11975
- Product name
- Fingolimod
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $429
- Updated
- 2024/03/01
- Product number
- F342045
- Product name
- Fingolimod
- Packaging
- 50mg
- Price
- $310
- Updated
- 2021/12/16
Gilenia Chemical Properties,Usage,Production
Chemical Properties
white solid
Uses
Prophylaxis of organ rejection in patients receiving allogenic renal transplants (sphingosine-1-phosphate receptor).
Uses
Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.
Definition
ChEBI: An aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimo is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate.
Clinical Use
Sphingosine 1-phosphate receptor modulator:Treatment of highly active relapsing-remitting multiple sclerosis
Drug interactions
Potentially hazardous interactions with other drugs Anti-arrhythmics: possible increased risk of bradycardia with amiodarone, disopyramide and dronedarone. Antifungals: concentration increased by ketoconazole. Beta-blockers: possibly increased risk of bradycardia. Calcium channel blockers: possible increased risk of bradycardia with diltiazem and verapamil.
Metabolism
Transformed by reversible stereoselective phosphorylation to the pharmacologically active (S)-enantiomer of fingolimod phosphate. It is eliminated by oxidative biotransformation mainly via the cytochrome P450 4F2 isoenzyme and subsequent fatty acid-like degradation to inactive metabolites, and by formation of pharmacologically inactive non-polar ceramide analogues of fingolimod. The main enzyme involved in the metabolism of fingolimod is partially identified and may be either CYP4F2 or CYP3A4. 81% excreted as inactive metabolites in the urine and <2.5% in the faeces as metabolites and unchanged drug.
Gilenia Preparation Products And Raw materials
Raw materials
Preparation Products
Gilenia Suppliers
- Tel
- 0551-65523315 17705606359
- Fax
- 0551-65523375
- errol@homesunshinepharma.com
- Country
- China
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- 70
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- 58
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- 025-52643182 13914798241
- Fax
- 025-52643182
- zhoulq@chemipioneer.com.cn
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- China
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- 71
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- Tel
- 021-20221225 13917446399
- Fax
- QQ:115820162
- sales@zhiwe.net
- Country
- China
- ProdList
- 578
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- 61
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44751
- Advantage
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- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
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- Country
- China
- ProdList
- 2882
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- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- zhangsn@titansci.com
- Country
- China
- ProdList
- 14113
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- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 17989
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- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15421
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- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
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- 66
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8849
- Advantage
- 52
View Lastest Price from Gilenia manufacturers
- Product
- Gilenia 162359-55-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500MT/month
- Release date
- 2022-01-19
- Product
- Gilenia 162359-55-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Gilenia 162359-55-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08