1-(5-Bromo-2,4-difluoro-phenyl)-ethanone
- Product Name
- 1-(5-Bromo-2,4-difluoro-phenyl)-ethanone
- CAS No.
- 864773-64-8
- Chemical Name
- 1-(5-Bromo-2,4-difluoro-phenyl)-ethanone
- Synonyms
- 1-(5-Bromo-2,4-difluorophenyl);5-broMo-2,4-difluoroacetophenobe;5'-Bromo-2',4'-difluoroacetophenone;5'-Bromo-2',4'-difluoroacetophenone 98%;1-(5-Bromo-2,4-difluoro-phenyl)-ethanone;Ethanone, 1-(5-bromo-2,4-difluorophenyl)-;1-(5-Bromo-2,4-difluorophenyl)ethan-1-one
- CBNumber
- CB92499625
- Molecular Formula
- C8H5BrF2O
- Formula Weight
- 235.03
- MOL File
- 864773-64-8.mol
1-(5-Bromo-2,4-difluoro-phenyl)-ethanone Property
- Boiling point:
- 254.0±40.0 °C(Predicted)
- Density
- 1.614±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystalline solid
- color
- White
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B997213
- Product name
- 1-(5-Bromo-2,4-difluorophenyl)ethanone
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 2617-B-22
- Product name
- 5'-Bromo-2',4'-difluoroacetophenone
- Purity
- 98%
- Packaging
- 5G
- Price
- $495
- Updated
- 2021/12/16
- Product number
- HCH0362010
- Product name
- 1-(5-BROMO-2,4-DIFLUOROPHENYL)ETHANONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.22
- Updated
- 2021/12/16
- Product number
- 075791
- Product name
- 1-(5-Bromo-2,4-difluorophenyl)ethanone
- Purity
- 95+%
- Packaging
- 5g
- Price
- $510
- Updated
- 2021/12/16
- Product number
- 2617-B-22
- Product name
- 5'-Bromo-2',4'-difluoroacetophenone
- Purity
- 98%
- Packaging
- 10g
- Price
- $795
- Updated
- 2021/12/16
1-(5-Bromo-2,4-difluoro-phenyl)-ethanone Chemical Properties,Usage,Production
Uses
1-(5-Bromo-2,4-difluoro-phenyl)-ethanone is a white powder crystal used in pharmaceutical synthesis and experimental research.
Synthesis
348-57-2
75-36-5
864773-64-8
1. in a dry reaction flask, anhydrous AlCl3 (1040 g, 7878.7 mmol) was added to 1-bromo-2,4-difluorobenzene (600 g, 3108.9 mmol) and stirred at 60 °C for 10 min. 2. acetyl chloride (366 g, 4662.4 mmol) was added slowly dropwise to the above mixture, maintaining the temperature at 60 °C for 4 hours. 3. after the dropwise addition was completed, the reaction mixture was continued to be stirred at 60 °C for 6 hours. 4. the reaction mixture was cooled to -10 °C and ice (2450 g) was added slowly, this process was controlled to be completed within 1.5 hours. 5. 12N HCl (1500mL) was added and stirred for 1 hour at room temperature. 6. EtOAc (9000mL) was added for extraction, the organic layer was separated, washed with water, dried over anhydrous Na2SO4 and filtered. 7. The organic phase was concentrated under pressure and the resulting residue was purified by silica gel column chromatography (eluent: petroleum ether/EtOAc, 50/1) to afford the target product 1-(5-bromo-2,4-difluorophenyl)ethanone (300 g, 41% yield).
References
[1] Patent: WO2011/154374, 2011, A1. Location in patent: Page/Page column 26
[2] Patent: WO2012/62751, 2012, A1. Location in patent: Page/Page column 41-42
[3] Patent: US2013/252952, 2013, A1. Location in patent: Paragraph 0167; 0168
[4] Patent: US2004/220194, 2004, A1. Location in patent: Page 44; 45
[5] Patent: US2005/239795, 2005, A1. Location in patent: Page/Page column 36
1-(5-Bromo-2,4-difluoro-phenyl)-ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(5-Bromo-2,4-difluoro-phenyl)-ethanone manufacturers
- Product
- 1-(5-Bromo-2,4-difluoro-phenyl)-ethanone 864773-64-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 5'-Bromo-2',4'-difluoroacetophenone 864773-64-8
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31
- Product
- 1-(5-Bromo-2,4-difluoro-phenyl)-ethanone 864773-64-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26