ChemicalBook > CAS DataBase List > GSK1904529A
GSK1904529A
- Product Name
- GSK1904529A
- CAS No.
- 1089283-49-7
- Chemical Name
- GSK1904529A
- Synonyms
- CS-29;GSK 4529;GSK1904529A;GSK1904529A, >=98%;GSK1904529A (GSK-4529;IGF-IR, IGF-IIR inhibitor;IGF-1R inhibitor GS1904529A;GSK1904529A ISO 9001：2015 REACH;GSK1904529A;GSK-1904529A;GSK 1904529A;GSK1904529A : IGF-IR, IGF-IIR inhibitor
- CBNumber
- CB92501005
- Molecular Formula
- C44H47F2N9O5S
- Formula Weight
- 851.96
- MOL File
- 1089283-49-7.mol
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GSK1904529A Property
- Density
- 1.39
- storage temp.
- Store at -20°C
- solubility
- ≥42.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- form
- solid
- pka
- 11.12±0.70(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 29155
- Product name
- GSK1904529A
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29155
- Product name
- GSK1904529A
- Packaging
- 25mg
- Price
- $456
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29155
- Product name
- GSK1904529A
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29155
- Product name
- GSK1904529A
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
TRC
- Product number
- G797490
- Product name
- GSK1904529A
- Packaging
- 5mg
- Price
- $170
- Updated
- 2021/12/16
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GSK1904529A Chemical Properties,Usage,Production
Uses
A selective inhibitor of IGF-1R and IR with IC50s of 27 nM and 25 nM, respectively.
Uses
GSK 1904529A is a small-molecule inhibitor of the insulin-like growth factor-I receptor tyrosine kinase.
Definition
ChEBI: N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide is a member of benzamides.
Biological Activity
gsk1904529a is a small-molecule inhibitor of the insulin-like growth factor-i receptor (igf-ir) with ic50 value of 27 nm 1.gsk1904529a is a reversible and atp-competitive inhibitor with ki value of 1.6 nm. in nih-3t3/lisn cells, gsk1904529a potently inhibited phosphorylation of igf-ir with ic50 value of 22 nm. it also demonstrated to be a selective inhibitor since it showed poor inhibitory activity against 45 other serine/threonine and tyrosine kinases. when treated with whole-cell extracts, gsk1904529a significantly inhibited the ligand-induced phosphorylation of igf-ir and decreased phosphorylation of downstream signaling including akt, irs-1 and erk at concentrations > 0.01μm. gsk1904529a suppressed cell proliferation in a variety of tumor cells. the ic50 values for nci-h929, tc-71, sk-n-mc, colo 205, mcf7 and prec are 81, 35, 43, 124, 137 and 68 nm, respectively. in colo 205, mcf-7, and nci-h929 cells, gsk1904529a treatment resulted in cell accumulation in g1 and decrease in s and g2-m phases. moreover, in nih-3t3/lisn xenograft model, once daily administration of gsk1904529a at 30 mg/kg inhibited 56% of tumor growth 1.
target
IGF1R
References
1. sabbatini p, rowand j l, groy a, et al. antitumor activity of gsk1904529a, a small-molecule inhibitor of the insulin-like growth factor-i receptor tyrosine kinase. clinical cancer research, 2009, 15(9): 3058-3067.
GSK1904529A Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GSK1904529A manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- GSK1904529A 1089283-49-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12