N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride

Product Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride
CAS No.: 478149-53-0
Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride
Synonyms: PHA-543613;PHA-543613 >=98% (HPLC);PHA 543613 hydrochloride;PHA 543613, 10 mM in DMSO;PHA-543,613 - CAS 478149-53-0 - Calbiochem;(R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carboxaMide;N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide;Furo[2,3-c]pyridine-5-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-;N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide;N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamidehydrochloride
CBNumber: CB92503302
Molecular Formula: C15H17N3O2
Formula Weight: 271.31
MOL File: 478149-53-0.mol

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N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Property

Melting point:: 313-315 °C
Boiling point:: 508.0±40.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMSO: ≥20mg/mL
form: White powder
pka: 12.19±0.20(Predicted)
color: white to off-white

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Safety

WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0135
Product name: PHA-543613
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $159
Updated: 2025/07/31

Sigma-Aldrich

Product number: PZ0135
Product name: PHA-543613
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $594
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.05316
Product name: PHA-543,613 - CAS 478149-53-0 - Calbiochem
Packaging: 5MG
Price: $179
Updated: 2022/05/15

Tocris

Product number: 3092
Product name: PHA543613hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $223
Updated: 2021/12/16

ApexBio Technology

Product number: B5373
Product name: PHA543613hydrochloride
Packaging: 10mg
Price: $332
Updated: 2021/12/16

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N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Chemical Properties,Usage,Production

Uses

PHA-543613 has been used to study its effect on recognition memory and neurovascular coupling (NVC) response in β-amyloid (Aβ) 25-35-treated mice. It has also been used to study its effect on Aβ25-35-induced receptor alteration and cognitive impairment in mice.

Definition

ChEBI: Pha-543613 is a phosphoramide and an organothiophosphorus compound.

Biological Activity

Primary Target
α7 nAChR

in vivo

PHA-543613 (0.3 mg/kg) successfully reverses Scopolamine-induced short-term memory deficits in rats^[2].? PHA-543613 (4 and 12 mg/kg; i.p. once) reduces behavioral deficits and brain edema^[3].

Animal Model:	Male CD-1 mice with (intracerebral hemorrhage) ICH-induction or sham surgery^[3]
Dosage:	4 and 12 mg/kg
Administration:	Intraperitoneal injection; 4 and 12 mg/kg; 1 hour after surgery
Result:	Increased p-Akt and decreased p-GSK-3 and CC3 expressions in the ipsilateral hemisphere and reduced the neuronal cell death in the perihematomal area. Attenuated behavioral deficits and brain edema at 72 hours after ICH.

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Suppliers

China 27 United Kingdom 1 United States 4 Global 32

Tocris Bioscience

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Email: customerservice@tocris.co.uk
Country: United Kingdom
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478149-53-0, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochlorideRelated Search:

PHA-543,613 - CAS 478149-53-0 - Calbiochem

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamidehydrochloride

PHA 543613 hydrochloride

PHA-543613

(R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carboxaMide

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxaMide hydrochlorid

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide

N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride

Furo[2,3-c]pyridine-5-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-

PHA-543613 >=98% (HPLC)

PHA 543613, 10 mM in DMSO

478149-53-0

C15H17N3O22HCl