N-Tosyl-L-alanine

Product Name: N-Tosyl-L-alanine
CAS No.: 21957-58-4
Chemical Name: N-Tosyl-L-alanine
Synonyms: N-Tosyl-L-Ala;Tos-Ala-OH,97%;N-Tosyl-L-alanine USP/EP/BP;N-(Toluene-4-sulfonyl)-L-alanine;N-[(4-Methylphenyl)sulfonyl]-L-alanine;L-Alanine,N-[(4-methylphenyl)sulfonyl]-;(S)-2-(4-MethylphenylsulfonaMido)propanoic acid;(2S)-2-(4-methylbenzenesulfonamido)propanoic acid;(2S)-2-[(4-methylphenyl)sulfonylamino]propanoicaci;(2S)-2-[[(4-Methylphenyl)sulfonyl]aMino]propanoic Acid
CBNumber: CB92505694
Molecular Formula: C10H13NO4S
Formula Weight: 243.28
MOL File: 21957-58-4.mol

More

Less

N-Tosyl-L-alanine Property

Melting point:: 138-139℃
Boiling point:: 428.9±55.0 °C(Predicted)
Density: 1.319
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Chloroform, Methanol
form: Solid
pka: 3.45±0.10(Predicted)
color: White
optical activity: Consistent with structure

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS004033
Product name: Tos-Ala-OH
Purity: AldrichCPR
Packaging: 250MG
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: M3484
Product name: Tos-Ala-OH
Packaging: 5G
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: M3484
Product name: Tos-Ala-OH
Packaging: 25G
Price: $119
Updated: 2025/07/31

TRC

Product number: T550525
Product name: N-Tosyl-L-alanine
Packaging: 500mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: 1110AB
Product name: N-Tosyl-L-alanine
Packaging: 100g
Price: $107
Updated: 2021/12/16

More

Less

N-Tosyl-L-alanine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

N-Tosyl-L-alanine (cas# 21957-58-4) is a compound useful in organic synthesis.

reaction suitability

reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

Synthesis

56-41-7

98-59-9

4816-81-3

GENERAL STEPS: The synthesis was carried out using the N-toluene sulfonylation method reported in the literature. In a round-bottomed flask, 2.4 equivalents of Na2CO3 was dissolved in water at 70 °C (concentration 0.66 mol/L). Subsequently, 1.0 equiv. of L-alanine was added, followed by the slow addition of 1.4 equiv. of p-toluenesulfonyl chloride. The resulting suspension was stirred and reacted at 70 °C for 40 min, followed by warming to 85 °C and continued stirring for 5 min. Upon completion of the reaction, the reaction mixture was filtered directly and the solids were washed with hot water at 85°C. The filtrate was cooled to room temperature and acidified with 6 M aqueous HCl to pH=1. The precipitated solid product was collected by filtration and dried under vacuum. The resulting 2-(4-methylphenylsulfonamido)propionic acid was used for subsequent experiments without further purification.

References

[1] RSC Advances, 2015, vol. 5, # 24, p. 18751 - 18760
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 29, p. 4006 - 4012
[3] Organic and Biomolecular Chemistry, 2013, vol. 11, # 21, p. 3451 - 3460
[4] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2000, vol. 55, # 2, p. 203 - 207
[5] Journal of Organic Chemistry, 2003, vol. 68, # 17, p. 6632 - 6638

N-Tosyl-L-alanine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-Tosyl-L-alanine Suppliers

Canada 1 China 51 India 3 Switzerland 2 United Kingdom 1 United States 5 Global 63

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Changzhou EFC Chemistry&Science Co.,Ltd

Tel: 18136598690 18136597130
Fax: 86-0519-89617886
Country: China
ProdList: 235
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chengdu Chuangkecheng Biological Technology Co., Ltd.

Tel: 028-028-0000000 13008177686
Fax: 15928581901
Email: sales@ckcbiotech.com
Country: China
ProdList: 904
Advantage: 55

Shanghai GL Peptide Ltd.

Tel: +86-21-61263340; 17609490614 13764994101
Fax: 021-61263399
Email: fisherwang@glschina.com
Country: China
ProdList: 8258
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

21957-58-4, N-Tosyl-L-alanineRelated Search:

(2S)-2-[[(4-Methylphenyl)sulfonyl]aMino]propanoic Acid

N-(Toluene-4-sulfonyl)-L-alanine

(2S)-2-(4-methylbenzenesulfonamido)propanoic acid

(S)-2-(4-MethylphenylsulfonaMido)propanoic acid

N-[(4-Methylphenyl)sulfonyl]-L-alanine

L-Alanine,N-[(4-methylphenyl)sulfonyl]-

(2S)-2-[(4-methylphenyl)sulfonylamino]propanoicaci

N-Tosyl-L-Ala

N-Tosyl-L-alanine USP/EP/BP

Tos-Ala-OH,97%

21957-58-4

Amino Acids & Derivatives