(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate

Product Name: (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
CAS No.: 179386-44-8
Chemical Name: (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
Synonyms: CS-414;U95666E;PNU 95666;PNU 95666E;PNU-95,666 maleate;Sumanirole maleate;PubChem ID: 9818478;CID 9818479 maleate;U 95666E(Sumanirole maleate);Sumanirole maleate >=98% (HPLC)
CBNumber: CB92510117
Molecular Formula: C15H17N3O5
Formula Weight: 319.32
MOL File: 179386-44-8.mol

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(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Property

Melting point:: 200-208°C (dec.)
storage temp.: -20°C
solubility: H2O: soluble10mg/mL, clear
form: powder
color: white to beige
optical activity: [α]/D -22 to -32°, c = 1 in H2O

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1087
Product name: Sumanirole maleate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $115
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1087
Product name: Sumanirole maleate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $184.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.05896
Product name: Sumanirole Maleate - CAS 179386-44-8 - Calbiochem
Packaging: 5mg
Price: $191
Updated: 2024/03/01

Cayman Chemical

Product number: 11984
Product name: Sumanirole (maleate)
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 11984
Product name: Sumanirole (maleate)
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

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(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Chemical Properties,Usage,Production

Uses

Sumanirole is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Sumanirole displays >200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). Sumanirole exhibits antiParkinsonian activity similar to Ropinirole (R641000).

Biochem/physiol Actions

Sumanirole is a highly selective and potent dopamine D2 receptor agonist that decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta. Sumanirole potently stimulates locomotor activity in in animal models of Parkinson′s disease.

storage

Store at -20°C

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Suppliers

China 43 India 1 United Kingdom 4 United States 7 Global 55

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179386-44-8, (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioateRelated Search:

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate

PNU 95666

Sumanirole maleate

U 95666E(Sumanirole maleate)

U95666E

PNU 95666E

(5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate

CID 9818479 maleate

PNU-95,666 maleate

PubChem ID: 9818478

(5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate (1:1)

CS-414

U95666E;PNU 95666;PNU 95666E;SUMANIROLE

Sumanirole maleate >=98% (HPLC)

179386-44-8

C11H13N3OC4H4O4