AM1172
- Product Name
- AM1172
- CAS No.
- 251908-92-6
- Chemical Name
- AM1172
- Synonyms
- AM1172;N-5Z,8Z,11Z,14Z-EICOSATETRAENYL-4-HYDROXY-BENZAMIDE;4-hydroxy-N-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenyl]benzamide;N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxybenzamide;Benzamide, N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxy-
- CBNumber
- CB9251038
- Molecular Formula
- C27H39NO2
- Formula Weight
- 409.6
- MOL File
- 251908-92-6.mol
AM1172 Property
- Boiling point:
- 590.8±50.0 °C(Predicted)
- Density
- 0.983±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in ethanol
- form
- solution in ethanol
- pka
- 8.53±0.26(Predicted)
N-Bromosuccinimide Price
- Product number
- 10005223
- Product name
- AM1172
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $87
- Updated
- 2024/03/01
- Product number
- 10005223
- Product name
- AM1172
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $163
- Updated
- 2024/03/01
- Product number
- 10005223
- Product name
- AM1172
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $680
- Updated
- 2024/03/01
- Product number
- 10005223
- Product name
- AM1172
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $1189
- Updated
- 2024/03/01
- Product number
- 3381
- Product name
- AM1172
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $193
- Updated
- 2021/12/16
AM1172 Chemical Properties,Usage,Production
Uses
AM 1172 is a potent and selective inhibitor of anandamide uptake and FAAH.
Biological Activity
Metabolically stable anandamide uptake inhibitor (IC 50 = 2.1 - 2.5 μ M) and fatty acid amide hydrolase (FAAH) inhibitor (K i = 3.18 μ M). Inhibits N -arachidonylethanolamine (AEA) accumulation (IC 50 = 24 μ M) and hydrolysis (K i = 3 μ M), and inhibits N -palmitoylethanolamine (PEA) hydrolysis (IC 50 = 36 μ M) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC 50 values are 189 and 271 nM at CB 2 and CB 1 receptors respectively).
References
1. fegley d, kathuria s, mercier r, et al. anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor am1172. proceedings of the national academy of sciences of the united states of america. 2004;101(23):8756-8761.