t-Butyl 1-(4-bromophenyl)cyclopropylcarbamate
- Product Name
- t-Butyl 1-(4-bromophenyl)cyclopropylcarbamate
- CAS No.
- 360773-84-8
- Chemical Name
- t-Butyl 1-(4-bromophenyl)cyclopropylcarbamate
- Synonyms
- tert-Butyl (1-(4-broMophenyl)cyclopropyl)carbaMate;tert-Butyl N-[1-(4-bromophenyl)cyclopropyl]carbamate;tert-Butyl (1-(4-bromophenyl);2-Fluoro-32-(methylthio)pyridine;N-Boc-1-(4-bromophenyl)cyclopropanamine;t-Butyl 1-(4-bromophenyl)cyclopropylcarbamate;1-(N-BOC-Amino)-1-(4-bromophenyl)cyclopropane;[1-(4-Bromo-phenyl)-cyclopropyl]-carbamic acid tert-butyl;[1-(4-Bromo-phenyl)-cyclopropyl]-carbamic acid tert-butyl ester;Carbamic acid, N-[1-(4-bromophenyl)cyclopropyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB92513709
- Molecular Formula
- C14H18BrNO2
- Formula Weight
- 312.2
- MOL File
- 360773-84-8.mol
t-Butyl 1-(4-bromophenyl)cyclopropylcarbamate Property
- Melting point:
- 126-128°
- Boiling point:
- 385.2±31.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.94±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C14H18BrNO2/c1-13(2,3)18-12(17)16-14(8-9-14)10-4-6-11(15)7-5-10/h4-7H,8-9H2,1-3H3,(H,16,17)
- InChIKey
- ZJEMFURAGDYBTG-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NC1(C2=CC=C(Br)C=C2)CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B603090
- Product name
- 1-(N-Boc-Amino)-1-(4-bromophenyl)cyclopropane
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- V5489
- Product name
- 1-(N-BOC-Amino)-1-(4-bromophenyl)cyclopropane
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 069477
- Product name
- tert-ButylN-[1-(4-bromophenyl)cyclopropyl]carbamate
- Packaging
- 1g
- Price
- $423
- Updated
- 2021/12/16
- Product number
- HCH0369836
- Product name
- TERT-BUTYL-(1-(4-BROMOPHENYL)CYCLOPROPYL)CARBAMATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.01
- Updated
- 2021/12/16
- Product number
- A200217
- Product name
- tert-Butyl(1-(4-bromophenyl)cyclopropyl)carbamate
- Purity
- 97%
- Packaging
- 25g
- Price
- $725
- Updated
- 2021/12/16
t-Butyl 1-(4-bromophenyl)cyclopropylcarbamate Chemical Properties,Usage,Production
Synthesis
24424-99-5
345965-54-0
360773-84-8
The general procedure for the synthesis of tert-butyl [1-(4-bromophenyl)-cyclopropyl]carbamate from 1-(4-bromophenyl)cyclopropan-1-amine and di-tert-butyl dicarbonate was as follows: in a 100-mL round-bottom flask, 1-(4-bromophenyl)cyclopropan-1-amine (1 g, 4.48 mmol, 1.00 equiv) and di-tert-butyl dicarbonate (3.1 g, 13.49 mmol , 3.01 eq.) were dissolved in tetrahydrofuran (20 mL). Subsequently, an aqueous solution of sodium bicarbonate (5 g, 59.5 mmol, 13.29 eq.) was slowly added to the reaction system (10 mL) at room temperature. The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (3 x 10 mL), the organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (10% to 50% gradient) as eluent to afford tert-butyl [1-(4-bromophenyl)-cyclopropyl]carbamate (1.47 g, 99%) as a light yellow solid. Mass spectrometry (MS) analysis showed: m/z = 255.7 [M+H-56]+.
References
[1] Patent: US2016/96834, 2016, A1. Location in patent: Paragraph 0390
[2] Patent: US2012/108574, 2012, A1. Location in patent: Page/Page column 113
[3] Patent: WO2016/57762, 2016, A1. Location in patent: Page/Page column 30
[4] Patent: WO2016/102672, 2016, A2. Location in patent: Page/Page column 115
t-Butyl 1-(4-bromophenyl)cyclopropylcarbamate Preparation Products And Raw materials
Raw materials
Preparation Products
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