(R)-(+)-THALIDOMIDE

Product Name: (R)-(+)-THALIDOMIDE
CAS No.: 2614-06-4
Chemical Name: (R)-(+)-THALIDOMIDE
Synonyms: NSC 91729;(+)-Thalidomide;(R)-(+)-THALIDOMIDE;Thalidomide (R)-Isomer;6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid;N-[(R)-2,6-Dioxopiperidine-3-yl]phthalimide;(+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide;2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione;6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2;(3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione
CBNumber: CB9251689
Molecular Formula: C13H10N2O4
Formula Weight: 258.23
MOL File: 2614-06-4.mol

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(R)-(+)-THALIDOMIDE Property

Melting point:: 269-271°C
Boiling point:: 401.48°C (rough estimate)
Density: 1.2944 (rough estimate)
refractive index: 1.5300 (estimate)
storage temp.: -20°C Freezer
solubility: DMSO: soluble
form: solid
pka: 10.70±0.40(Predicted)
color: white

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Safety

Hazard Codes: T
Risk Statements: 61-22
Safety Statements: 53-36/37/39-45
WGK Germany: 3
RTECS: TI4925000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T151
Product name: (+)-Thalidomide
Purity: ≥98%(HPLC),powder
Packaging: 10mg
Price: $128
Updated: 2024/03/01

Sigma-Aldrich

Product number: T151
Product name: (+)-Thalidomide
Purity: ≥98%(HPLC),powder
Packaging: 100mg
Price: $826
Updated: 2024/03/01

TRC

Product number: T338855
Product name: (R)-(+)-Thalidomide
Packaging: 50mg
Price: $495
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000090
Product name: (R)-(+)-THALIDOMIDE
Purity: 95.00%
Packaging: 5MG
Price: $738.1
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 13778
Product name: (R)-(+)-Thalidomide
Packaging: 10mg
Price: $490
Updated: 2021/12/16

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(R)-(+)-THALIDOMIDE Chemical Properties,Usage,Production

Chemical Properties

Needles

Uses

Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.

Uses

Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.

Definition

ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has R-configuration at the chiral centre.

Biochem/physiol Actions

(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.

(R)-(+)-THALIDOMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-THALIDOMIDE Suppliers

Canada 3 China 24 Germany 1 India 3 Switzerland 1 Ukraine 1 United States 12 Global 45

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2614-06-4, (R)-(+)-THALIDOMIDERelated Search:

(-)-THALIDOMIDE >98% INHIBITOR OF ANGIOG EN,(S)-(-)-THALIDOMIDE (+-)-THALIDOMIDE >98% IMMUNOSUPPRESSIVE, SE,(+/-)-THALIDOMIDE,THALIDOMIDE,Thalidomide (soluble form) (R)-3-AMINOPIPERIDIN-2-ONE 3-amino-2-Piperidinone (R)-(+)-THALIDOMIDE (R)-3-Aminopiperidine 3-AMINOPIPERIDINE Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). N-(piperidin-3-yl)benzamide 3-ACETAMIDOPIPERIDINE 3-DIMETHYLAMINOPIPERIDINE N-(2-AMINO-ETHYL)-PHTHALIMIDE THALIDOMIDE-D4 5'-HYDROXY THALIDOMIDE 3-(N-ACETYL-N-METHYLAMINO)PIPERIDINE Thalidomide (+ and -) 2-(2-(3-azido-4-iodophenylpropionamido)ethoxy)thalidomide THALIDOMIDE UN2811-III

(R)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3-(2H)-DIONE

R-(+)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE

(R)-(+)-THALIDOMIDE

6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2

6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid

(+)-2-[(R)-2,6-Dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione

(+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide

(3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione

N-[(R)-2,6-Dioxopiperidine-3-yl]phthalimide

NSC 91729

2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione

Thalidomide (R)-Isomer

1H-Isoindole-1,3(2H)-dione, 2-[(3R)-2,6-dioxo-3-piperidinyl]-

(+)-Thalidomide

2614-06-4

6/4/2614

2614-6-4

Angiogenesis Regulators

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Extracellular Matrix

Cytoskeleton and Extracellular Matrix

Chiral Reagents

Intermediates & Fine Chemicals

Pharmaceuticals