(R)-(+)-THALIDOMIDE
- Product Name
- (R)-(+)-THALIDOMIDE
- CAS No.
- 2614-06-4
- Chemical Name
- (R)-(+)-THALIDOMIDE
- Synonyms
- NSC 91729;(+)-Thalidomide;(R)-(+)-THALIDOMIDE;Thalidomide (R)-Isomer;6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid;N-[(R)-2,6-Dioxopiperidine-3-yl]phthalimide;(+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide;2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione;6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2;(3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione
- CBNumber
- CB9251689
- Molecular Formula
- C13H10N2O4
- Formula Weight
- 258.23
- MOL File
- 2614-06-4.mol
(R)-(+)-THALIDOMIDE Property
- Melting point:
- 269-271°C
- Boiling point:
- 401.48°C (rough estimate)
- Density
- 1.2944 (rough estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- DMSO: soluble
- form
- solid
- pka
- 10.70±0.40(Predicted)
- color
- white
Safety
- Hazard Codes
- T
- Risk Statements
- 61-22
- Safety Statements
- 53-36/37/39-45
- WGK Germany
- 3
- RTECS
- TI4925000
N-Bromosuccinimide Price
- Product number
- T151
- Product name
- (+)-Thalidomide
- Purity
- ≥98%(HPLC),powder
- Packaging
- 10mg
- Price
- $128
- Updated
- 2024/03/01
- Product number
- T151
- Product name
- (+)-Thalidomide
- Purity
- ≥98%(HPLC),powder
- Packaging
- 100mg
- Price
- $826
- Updated
- 2024/03/01
- Product number
- T338855
- Product name
- (R)-(+)-Thalidomide
- Packaging
- 50mg
- Price
- $495
- Updated
- 2021/12/16
- Product number
- API0000090
- Product name
- (R)-(+)-THALIDOMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $738.1
- Updated
- 2021/12/16
- Product number
- 13778
- Product name
- (R)-(+)-Thalidomide
- Packaging
- 10mg
- Price
- $490
- Updated
- 2021/12/16
(R)-(+)-THALIDOMIDE Chemical Properties,Usage,Production
Chemical Properties
Needles
Uses
Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.
Uses
Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.
Definition
ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has R-configuration at the chiral centre.
Biochem/physiol Actions
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.
(R)-(+)-THALIDOMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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