ChemicalBook > CAS DataBase List > AZ-23

AZ-23

Product Name
AZ-23
CAS No.
915720-21-7
Chemical Name
AZ-23
Synonyms
AZ-23;AZ23; AZ-23;Tropomyosin related kinase receptor,Inhibitor,inhibit,AZ-23,Trk Receptor;5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine;(S)-5-chloro-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine;2,4-Pyrimidinediamine, 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyridinyl)ethyl]-N4-[5-(1-methylethoxy)-1H-pyrazol-3-yl]-
CBNumber
CB92518274
Molecular Formula
C17H19ClFN7O
Formula Weight
391.8304632
MOL File
915720-21-7.mol
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AZ-23 Property

Boiling point:
596.1±60.0 °C(Predicted)
Density 
1.411
storage temp. 
Store at -20°C
solubility 
DMSO:125.0(Max Conc. mg/mL);319.02(Max Conc. mM)
pka
12.37±0.10(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C424360
Product name
5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N''-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Packaging
25mg
Price
$1470
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA102951
Product name
AZ 23
Packaging
10mg
Price
$185
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001065
Product name
AZ-23
Purity
95.00%
Packaging
2MG
Price
$234
Updated
2021/12/16
AK Scientific
Product number
2363CW
Product name
AZ-23
Packaging
10mg
Price
$299
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001065
Product name
AZ-23
Purity
95.00%
Packaging
5MG
Price
$501.68
Updated
2021/12/16
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AZ-23 Chemical Properties,Usage,Production

Uses

5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZ-23) is a potent and selective tyrosine kinase inhibitor which may be used in the therapeutic treatment of cancers.

Biological Activity

AZ-23 is an ATP-competitive, orally active Trk kinase A/B/C inhibitor with IC50 values of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3) , 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck).

in vitro

AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC 50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines.

in vivo

AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma .

target

TrkA

2 nM (IC 50 )

TrkB

8 nM (IC 50 )

AZ-23 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ-23 Suppliers

China 38 The Netherlands 1 United Kingdom 1 United States 5 Global 45
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30

915720-21-7, AZ-23Related Search:

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

  • (S)-5-chloro-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
  • AZ-23
  • 5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
  • AZ23; AZ-23
  • 2,4-Pyrimidinediamine, 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyridinyl)ethyl]-N4-[5-(1-methylethoxy)-1H-pyrazol-3-yl]-
  • Tropomyosin related kinase receptor,Inhibitor,inhibit,AZ-23,Trk Receptor
  • 915720-21-7
  • C17H19ClFN7O