AZ-23
- Product Name
- AZ-23
- CAS No.
- 915720-21-7
- Chemical Name
- AZ-23
- Synonyms
- AZ-23;AZ23; AZ-23;Tropomyosin related kinase receptor,Inhibitor,inhibit,AZ-23,Trk Receptor;5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine;(S)-5-chloro-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine;2,4-Pyrimidinediamine, 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyridinyl)ethyl]-N4-[5-(1-methylethoxy)-1H-pyrazol-3-yl]-
- CBNumber
- CB92518274
- Molecular Formula
- C17H19ClFN7O
- Formula Weight
- 391.8304632
- MOL File
- 915720-21-7.mol
AZ-23 Property
- Boiling point:
- 596.1±60.0 °C(Predicted)
- Density
- 1.411
- storage temp.
- Store at -20°C
- solubility
- DMSO:125.0(Max Conc. mg/mL);319.02(Max Conc. mM)
- pka
- 12.37±0.10(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C424360
- Product name
- 5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N''-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
- Packaging
- 25mg
- Price
- $1470
- Updated
- 2021/12/16
- Product number
- FA102951
- Product name
- AZ 23
- Packaging
- 10mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- KIN0001065
- Product name
- AZ-23
- Purity
- 95.00%
- Packaging
- 2MG
- Price
- $234
- Updated
- 2021/12/16
- Product number
- 2363CW
- Product name
- AZ-23
- Packaging
- 10mg
- Price
- $299
- Updated
- 2021/12/16
- Product number
- KIN0001065
- Product name
- AZ-23
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.68
- Updated
- 2021/12/16
AZ-23 Chemical Properties,Usage,Production
Uses
5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZ-23) is a potent and selective tyrosine kinase inhibitor which may be used in the therapeutic treatment of cancers.
Biological Activity
AZ-23 is an ATP-competitive, orally active Trk kinase A/B/C inhibitor with IC50 values of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3) , 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck).
in vitro
AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC 50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines.
in vivo
AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma .
target
| TrkA 2 nM (IC 50 ) | TrkB 8 nM (IC 50 ) |
AZ-23 Preparation Products And Raw materials
Raw materials
Preparation Products
AZ-23 Suppliers
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
- Advantage
- 58
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- support@targetmol.com
- Country
- United States
- ProdList
- 38631
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52924
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58