5-Chloro-3-methylpyridine-2-carbonitrile
- Product Name
- 5-Chloro-3-methylpyridine-2-carbonitrile
- CAS No.
- 156072-84-3
- Chemical Name
- 5-Chloro-3-methylpyridine-2-carbonitrile
- Synonyms
- 5-Chloro-3-Methylpicolinonitrile;5-chloro-3-methyl-2-Pyridinecarbonitrile;5-Chloro-3-methylpyridine-2-carbonitrile;2-Pyridinecarbonitrile, 5-chloro-3-methyl-;5-Chloro-2-cyano-3-methylpyridine, 5-Chloro-3-methylpicolinonitrile
- CBNumber
- CB92526394
- Molecular Formula
- C7H5ClN2
- Formula Weight
- 152.58
- MOL File
- 156072-84-3.mol
5-Chloro-3-methylpyridine-2-carbonitrile Property
- storage temp.
- Store at room temperature
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C587635
- Product name
- 5-Chloro-3-methylpyridine-2-carbonitrile
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC140122
- Product name
- 5-Chloro-3-methylpicolinonitrile
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- Z4212
- Product name
- 5-Chloro-3-methylpicolinonitrile
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
- Product number
- FC140122
- Product name
- 5-Chloro-3-methylpicolinonitrile
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FC140122
- Product name
- 5-Chloro-3-methylpicolinonitrile
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
5-Chloro-3-methylpyridine-2-carbonitrile Chemical Properties,Usage,Production
Synthesis
557-21-1
65550-77-8
156072-84-3
2-Bromo-5-chloro-3-methylpyridine (45 g, 218 mmol) and zinc cyanide (8.30 mL, 131 mmol) were added to a tris(dibenzylideneacetone)dipalladium(0) (4.99 g, 5.45 mmol) and 1,1'-bis(diphenylphosphino)ferrocene (6.04 g, 10.90 mmol) dimethylacetamide (40 mL ) solution. The mixture was heated to 110 °C and reacted for 4 hours. After completion of the reaction, it was cooled to room temperature, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic phases were combined and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using an ISCO system eluting with a 0-60% ethyl acetate/hexane gradient to afford the target product 2-cyano-3-methyl-5-chloropyridine (25.4 g, 166 mmol, 76% yield). The product was detected by LC/MS (ESI+) with m/z = 153.1 ([M+H]+).
References
[1] Patent: WO2014/138484, 2014, A1. Location in patent: Page/Page column 143
[2] Patent: US2015/38497, 2015, A1. Location in patent: Paragraph 0993
[3] Patent: WO2016/22724, 2016, A1. Location in patent: Page/Page column 294; 295
5-Chloro-3-methylpyridine-2-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
5-Chloro-3-methylpyridine-2-carbonitrile Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
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- Fax
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
View Lastest Price from 5-Chloro-3-methylpyridine-2-carbonitrile manufacturers
- Product
- 5-Chloro-3-methylpyridine-2-carbonitrile 156072-84-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-13
- Product
- 5-Chloro-3-methylpyridine-2-carbonitrile 156072-84-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-13