Methyl 5-chloro-6-methylpyrazine-2-carboxylate

Pharmaceutical intermediate

Product Name: Methyl 5-chloro-6-methylpyrazine-2-carboxylate
CAS No.: 77168-85-5
Chemical Name: Methyl 5-chloro-6-methylpyrazine-2-carboxylate
Synonyms: N-1H-BENZIMIDAZOL-4-YLFORMAMIDE;Methyl 5-chloro-6-methylpyrazine-2-carboxylate;1,4-Butanediamine,N1,N4-bis(7-chloro-5-quinolinyl)-;5-Chloro-6-methyl-2-pyrazinecarboxylic acid methyl ester;5-Chloro-6-methyl-pyrazine-2-carboxylic acid methyl ester;2-Pyrazinecarboxylic acid, 5-chloro-6-methyl-, methyl ester;Methyl 5-chloro-6-methylpyrazine-2-carboxylate ISO 9001：2015 REACH
CBNumber: CB92534595
Molecular Formula: C7H7ClN2O2
Formula Weight: 186.6
MOL File: 77168-85-5.mol

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Methyl 5-chloro-6-methylpyrazine-2-carboxylate Property

Melting point:: 40-43℃
Boiling point:: 260℃
Density: 1.314
Flash point:: 111℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder
pka: -3.86±0.10(Predicted)
color: Yellow
InChI: InChI=1S/C7H7ClN2O2/c1-4-6(8)9-3-5(10-4)7(11)12-2/h3H,1-2H3
InChIKey: GGNGFNQPYMKDDR-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC(C)=C(Cl)N=C1

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

TRC

Product number: M329985
Product name: Methyl5-Chloro-6-methylpyrazine-2-carboxylate
Packaging: 25mg
Price: $85
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC143858
Product name: 5-Chloro-6-methyl-2-pyrazinecarboxylic acid methyl ester
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC143858
Product name: 5-Chloro-6-methyl-2-pyrazinecarboxylic acid methyl ester
Packaging: 1g
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: J95233
Product name: Methyl5-chloro-6-methylpyrazine-2-carboxylate
Packaging: 1g
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC143858
Product name: 5-Chloro-6-methyl-2-pyrazinecarboxylic acid methyl ester
Packaging: 2g
Price: $220
Updated: 2021/12/16

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Methyl 5-chloro-6-methylpyrazine-2-carboxylate Chemical Properties,Usage,Production

Pharmaceutical intermediate

The N-methyl-d-aspartate (NMDA) receptor is arguably an important signaling mechanism in the human brain and NMDA receptors play a critical role in regulating the strength of synapses, that is, in regulating synaptic plasticity. Methyl 5-chloro-6-methylpyrazine-2-carboxylate is the key materials to prepare the NMDA receptor.

Uses

Methyl 5-?Chloro-?6-?methylpyrazine-?2-?carboxylate is a reactant used in the synthesis of 4,5-dihydro-5-oxo-2-pyrazinecarboxylic acid 1-oxides.

Synthesis

77168-84-4

77168-85-5

The general procedure for the synthesis of methyl 5-chloro-6-methylpyrazine-2-carboxylate from methyl 6-methyl-5-oxo-4,5-dihydropyrazine-2-carboxylate was as follows: a solution of methyl 6-methyl-5-oxo-4,5-dihydropyrazine-2-carboxylate was added to POCl3 (20 mL) in DMF (20 mL). The reaction mixture was refluxed for 0.5 h and subsequently poured into ice water. The aqueous layer was extracted with CHCl3 and the organic phase was dried and concentrated with MgSO4. The residue was purified by silica gel column chromatography (eluent: CHCl3) to afford methyl 5-chloro-6-methylpyrazine-2-carboxylate (2.34 g, 52% yield); melting point 49-50 °C.

References

[1] Chemical and Pharmaceutical Bulletin, 1980, vol. 28, # 10, p. 3057 - 3063
[2] Patent: US5811428, 1998, A

Methyl 5-chloro-6-methylpyrazine-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 5-chloro-6-methylpyrazine-2-carboxylate Suppliers

China 65 India 1 United Kingdom 3 United States 6 Global 75

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
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Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
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Aladdin Scientific

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Synthonix Inc

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United States Biological

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SynQuest Laboratories, Inc.

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Country: United States
ProdList: 6871
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View Lastest Price from Methyl 5-chloro-6-methylpyrazine-2-carboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Chloro-6-methyl-2-pyrazinecarboxylic acid methyl ester 77168-85-5
Price: US $0.00-0.00/KG
Min. Order: 10g
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2019-12-25

Career Henan Chemical Co

Product: Methyl 5-chloro-6-methylpyrazine-2-carboxylate 77168-85-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2020-01-13

77168-85-5, Methyl 5-chloro-6-methylpyrazine-2-carboxylateRelated Search:

5-Chloro-6-methyl-2-pyrazinecarboxylic acid methyl ester

Methyl 5-chloro-6-methylpyrazine-2-carboxylate

5-Chloro-6-methyl-pyrazine-2-carboxylic acid methyl ester

N-1H-BENZIMIDAZOL-4-YLFORMAMIDE

2-Pyrazinecarboxylic acid, 5-chloro-6-methyl-, methyl ester

Methyl 5-chloro-6-methylpyrazine-2-carboxylate ISO 9001：2015 REACH

1,4-Butanediamine,N1,N4-bis(7-chloro-5-quinolinyl)-

77168-85-5

7168-85-5