ChemicalBook > CAS DataBase List > PF 04217903 mesylate

PF 04217903 mesylate

Product Name: PF 04217903 mesylate
CAS No.: 956906-93-7
Chemical Name: PF 04217903 mesylate
Synonyms: PF-04217903.MsOH;PF 04217903 mesylate;HBEMHKVWZJTVOC-UHFFFAOYSA-N;PF-04217903 Methanesulfonate;PF-04217903 mesylate/PF04217903 mesylate;PF04217903 METHANESULFONATE;PF 04217903 METHANESULFONATE;4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol mesylate;4-[1-(6-QuinolinylMethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol Methanesulfonate;4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol methanesulfonate (1:1);2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethan-1-ol methanesulfonate
CBNumber: CB92535688
Molecular Formula: C20H20N8O4S
Formula Weight: 468.49
MOL File: 956906-93-7.mol

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PF 04217903 mesylate Property

storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL (warmed)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0263
Product name: PF-04217903
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $138
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0263
Product name: PF-04217903
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $375
Updated: 2025/07/31

Tocris

Product number: 4239
Product name: PF04217903mesylate
Purity: ≥98%(HPLC)
Packaging: 10
Price: $284
Updated: 2021/12/16

TRC

Product number: P293990
Product name: PF04217903Mesylate
Packaging: 10mg
Price: $195
Updated: 2021/12/16

TRC

Product number: P293990
Product name: PF04217903Mesylate
Packaging: 100mg
Price: $1540
Updated: 2021/12/16

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PF 04217903 mesylate Chemical Properties,Usage,Production

Uses

PF 04217903 is highly selective, high affinity c-Met inhibitor (Ki = 6-7 nM against wild type c-Met). Displays >1000-fold selectivity for c-Met over a panel of 208 kinases.

Biological Activity

PF-04217903 is a highly selective, potent inhibitor of the hepatocyte growth factor receptor c-Met. PF-04217903 inhibits endogenous, wild type c-Met in A549 human lung carcinoma cells with an IC50 of 4.8 nM. The compund displays 1000-fold selectivity against a panel of 208 other kinases.', 'PF-04217903 is an ATP-competitive inhibitor. It elicits antiangiogenic functionality. PF-04217903 inhibits c-Met phosphorylation in xenograft models leading to partial tumor growth suppression.

in vivo

PF-04217903 mesylate (1-30 mg/kg; p.o.; daily for 16 days) shows dose-dependent tumor growth inhibition, which correlated with the inhibition in c-Met phosphorylation in these tumors ^[1].
PF-04217903 mesylate (5-50 mg/kg, p.o.; once daily for 3 days) dose dependently inhibits c-Met, Gab-1, Erk1/2, and AKT phosphorylation and induced apoptosis (cleaved caspase-3) in U87MG xenograft tumors at all dose levels. PF-04217903 mesylate shows a significant dose-dependent reduction of human IL-8 levels in both the U87MG and GTL-16 models and decreases human VEGFA levels in the GTL-16 model. PF-04217903 mesylate strongly induces phospho-PDGFRβ levels in U87MG xenograft tumors^[1].

Animal Model:	Female nu/nu mice GTL-16 xenograft model^[1]
Dosage:	1, 3, 10, 30 mg/kg
Administration:	Oral; daily for 16 days
Result:	Showed dose-dependent tumor growth inhibition, and was correlated with the inhibition in c-Met phosphorylation in these tumors.

storage

Store at +4°C

PF 04217903 mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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956906-93-7, PF 04217903 mesylateRelated Search:

PF 04217903 mesylate

4-[1-(6-QuinolinylMethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol Methanesulfonate

PF-04217903 Methanesulfonate

PF04217903 METHANESULFONATE;PF 04217903 METHANESULFONATE

4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol mesylate

4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol methanesulfonate (1:1)

PF-04217903.MsOH

HBEMHKVWZJTVOC-UHFFFAOYSA-N

2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethan-1-ol methanesulfonate

PF-04217903 mesylate/PF04217903 mesylate

956906-93-7

C19H16N8OCH4O3S

C20H20N8O4S

CH4O3SC19H16N8O

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