PF 04217903 mesylate

Product Name: PF 04217903 mesylate
CAS No.: 956906-93-7
Chemical Name: PF 04217903 mesylate
Synonyms: PF-04217903.MsOH;PF 04217903 mesylate;HBEMHKVWZJTVOC-UHFFFAOYSA-N;PF-04217903 Methanesulfonate;PF-04217903 mesylate/PF04217903 mesylate;PF04217903 METHANESULFONATE;PF 04217903 METHANESULFONATE;4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol mesylate;4-[1-(6-QuinolinylMethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol Methanesulfonate;4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol methanesulfonate (1:1);2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethan-1-ol methanesulfonate
CBNumber: CB92535688
Molecular Formula: C20H20N8O4S
Formula Weight: 468.49
MOL File: 956906-93-7.mol

More

Less

PF 04217903 mesylate Property

storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL (warmed)
form: powder
color: white to beige

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0263
Product name: PF-04217903
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $138
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0263
Product name: PF-04217903
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $375
Updated: 2025/07/31

Tocris

Product number: 4239
Product name: PF04217903mesylate
Purity: ≥98%(HPLC)
Packaging: 10
Price: $284
Updated: 2021/12/16

TRC

Product number: P293990
Product name: PF04217903Mesylate
Packaging: 10mg
Price: $195
Updated: 2021/12/16

TRC

Product number: P293990
Product name: PF04217903Mesylate
Packaging: 100mg
Price: $1540
Updated: 2021/12/16

More

Less

PF 04217903 mesylate Chemical Properties,Usage,Production

Uses

PF 04217903 is highly selective, high affinity c-Met inhibitor (Ki = 6-7 nM against wild type c-Met). Displays >1000-fold selectivity for c-Met over a panel of 208 kinases.

Biological Activity

PF-04217903 is a highly selective, potent inhibitor of the hepatocyte growth factor receptor c-Met. PF-04217903 inhibits endogenous, wild type c-Met in A549 human lung carcinoma cells with an IC50 of 4.8 nM. The compund displays 1000-fold selectivity against a panel of 208 other kinases.', 'PF-04217903 is an ATP-competitive inhibitor. It elicits antiangiogenic functionality. PF-04217903 inhibits c-Met phosphorylation in xenograft models leading to partial tumor growth suppression.

in vivo

PF-04217903 mesylate (1-30 mg/kg; p.o.; daily for 16 days) shows dose-dependent tumor growth inhibition, which correlated with the inhibition in c-Met phosphorylation in these tumors ^[1].
PF-04217903 mesylate (5-50 mg/kg, p.o.; once daily for 3 days) dose dependently inhibits c-Met, Gab-1, Erk1/2, and AKT phosphorylation and induced apoptosis (cleaved caspase-3) in U87MG xenograft tumors at all dose levels. PF-04217903 mesylate shows a significant dose-dependent reduction of human IL-8 levels in both the U87MG and GTL-16 models and decreases human VEGFA levels in the GTL-16 model. PF-04217903 mesylate strongly induces phospho-PDGFRβ levels in U87MG xenograft tumors^[1].

Animal Model:	Female nu/nu mice GTL-16 xenograft model^[1]
Dosage:	1, 3, 10, 30 mg/kg
Administration:	Oral; daily for 16 days
Result:	Showed dose-dependent tumor growth inhibition, and was correlated with the inhibition in c-Met phosphorylation in these tumors.

storage

Store at +4°C

PF 04217903 mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

PF 04217903 mesylate Suppliers

Canada 1 China 46 India 2 United Kingdom 1 United States 12 Global 62

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

956906-93-7, PF 04217903 mesylateRelated Search:

PF 04217903 mesylate

4-[1-(6-QuinolinylMethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol Methanesulfonate

PF-04217903 Methanesulfonate

PF04217903 METHANESULFONATE;PF 04217903 METHANESULFONATE

4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol mesylate

4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol methanesulfonate (1:1)

PF-04217903.MsOH

HBEMHKVWZJTVOC-UHFFFAOYSA-N

2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethan-1-ol methanesulfonate

PF-04217903 mesylate/PF04217903 mesylate

956906-93-7

C19H16N8OCH4O3S

C20H20N8O4S

CH4O3SC19H16N8O

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pfizer Compounds

Pharmaceuticals