A 839977

Product Name: A 839977
CAS No.: 870061-27-1
Chemical Name: A 839977
Synonyms: A 839977;ACHEMBLOCK F-4551;A 839977, 10 mM in DMSO;1-(2,3-Dichlorophenyl)-N-(2-(pyridin-2-yloxy)benzyl)-1H-tetrazol-5-amine;1-(2,3-dichlorophenyl)-n-[2-(2-pyridinyloxy)benzyl]-1h-tetrazol-5 -amine;1-(2,3-dichlorophenyl)-N-[(2-pyridin-2-yloxyphenyl)methyl]tetrazol-5-amine;1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]Methyl]-1H-tetrazol-5-aMine;1H-Tetrazol-5-amine, 1-(2,3-dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-;1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine;1-(2,3-DICHLOROPHENYL)-N-{[2-(PYRIDIN-2-YLOXY)PHENYL]METHYL}-1H-1,2,3,4-TETRAZOL-5-AMINE
CBNumber: CB92538270
Molecular Formula: C19H14Cl2N6O
Formula Weight: 413.26
MOL File: 870061-27-1.mol

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A 839977 Property

Boiling point:: 604.9±65.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solid
pka: 2.96±0.12(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 4232
Product name: A839977
Purity: ≥98%(HPLC)
Packaging: 10
Price: $217
Updated: 2021/12/16

Tocris

Product number: 4232
Product name: A839977
Purity: ≥98%(HPLC)
Packaging: 50
Price: $851
Updated: 2021/12/16

TRC

Product number: A965365
Product name: A839977
Packaging: 2.5mg
Price: $195
Updated: 2021/12/16

Usbiological

Product number: 254483
Product name: A 839977
Packaging: 10mg
Price: $466
Updated: 2021/12/16

TRC

Product number: A965365
Product name: A839977
Packaging: 1mg
Price: $85
Updated: 2021/12/16

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A 839977 Chemical Properties,Usage,Production

Uses

A 839977 is a selective P2X7 receptor antagonist.

Biological Activity

a839977 is a novel and selective antagonist of p2x7 receptor with the ic50 values of 20 nm, 42nm and 150nm for human, rat and mouse, respectively [1].a839977 has been reported to block bzatp-evoked changes in intracellular calcium concentrations in 132n1 cells stable expressing p2x7 receptors with the ic50 values of 20 nm, 42nm and 150nm for human, rat and mouse, respectively. in addition, a839977 has also revealed to inhibit bzatp-stimulated il-1β release and yo-pro uptake with the ic50 of 37nm and 7nm, respectively, in differentiated human thp-1 cells. besides, a839977 has been noted to produce parallel rightward shifts in bzatp concentration-effect calcium influx curves with the paα value of 8.1. apart from these, a839977 has been exhibited to reduce cfa-induced thermal hyperalgesia in a dose-dependent fashion with the ed50 value of 100μmol/kg(i.p.) [1].

in vivo

A 839977 (30 μmol/kg, 100 μmol/kg, 300 μmol/kg; pre-injected 30mins) dose-dependently reduces thermal hyperalgesia produced by intraplantar administration of complete Freund's adjuvant (CFA) in rats^[1].
A 839977 (10 μmol/kg, 30 μmol/kg, 100 μmol/kg; pre-injected 30mins) produces robust antihyperalgesia in the CFA model of inflammatory pain in wild-type mice, but it has no effect on IL-1alphabeta knockout mice^[1].
A 839977 attenuates dorsal horn neuronal responses in cancer bearing animals^[3].

Animal Model:	Male Sprague-Dawley, BALB/c mice and IL-1^(?/?) mice for CFA-induced chronic inflammatory
Dosage:	30 μmol/kg, 100 μmol/kg, 300 μmol/kg (rat); 10 μmol/kg, 30 μmol/kg, 100 μmol/kg (mice)
Administration:	Injection; pre-injected 30mins
Result:	Attenuated CFA-induced thermal hyperalgesia in a dose-related manner in rat and mice, but has no effect on IL-1^(?/?) mice.

IC 50

P2X7 Receptor

storage

Store at +4°C

References

[1] honore p1, donnelly-roberts d, namovic m, zhong c, wade c, chandran p, zhu c, carroll w, perez-medrano a, iwakura y, jarvis mf. the antihyperalgesic activity of a selective p2x7 receptor antagonist, a-839977, is lost in il-1alphabeta knockout mice. behav brain res. 2009 dec 1;204(1):77-81.

A 839977 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 839977 Suppliers

China 50 United Kingdom 2 United States 10 Global 62

BOC Sciences

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870061-27-1, A 839977Related Search:

A 839977

1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]Methyl]-1H-tetrazol-5-aMine

1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine

1-(2,3-dichlorophenyl)-N-[(2-pyridin-2-yloxyphenyl)methyl]tetrazol-5-amine

1-(2,3-dichlorophenyl)-n-[2-(2-pyridinyloxy)benzyl]-1h-tetrazol-5 -amine

A839977 1-(2,3-dichlorophenyl)-N-{[2-(pyridin-2-yloxy)phenyl]methyl}-1H-1,2,3,4-tetrazol-5-amine

ACHEMBLOCK F-4551

1-(2,3-DICHLOROPHENYL)-N-{[2-(PYRIDIN-2-YLOXY)PHENYL]METHYL}-1H-1,2,3,4-TETRAZOL-5-AMINE

1H-Tetrazol-5-amine, 1-(2,3-dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-

1-(2,3-Dichlorophenyl)-N-(2-(pyridin-2-yloxy)benzyl)-1H-tetrazol-5-amine

A 839977, 10 mM in DMSO

870061-27-1

C19H14Cl2N6O