ChemicalBook > CAS DataBase List > A 839977

A 839977

Product Name
A 839977
CAS No.
870061-27-1
Chemical Name
A 839977
Synonyms
A 839977;ACHEMBLOCK F-4551;1-(2,3-dichlorophenyl)-n-[2-(2-pyridinyloxy)benzyl]-1h-tetrazol-5 -amine;1-(2,3-dichlorophenyl)-N-[(2-pyridin-2-yloxyphenyl)methyl]tetrazol-5-amine;1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]Methyl]-1H-tetrazol-5-aMine;1H-Tetrazol-5-amine, 1-(2,3-dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-;1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine;1-(2,3-DICHLOROPHENYL)-N-{[2-(PYRIDIN-2-YLOXY)PHENYL]METHYL}-1H-1,2,3,4-TETRAZOL-5-AMINE;A839977 1-(2,3-dichlorophenyl)-N-{[2-(pyridin-2-yloxy)phenyl]methyl}-1H-1,2,3,4-tetrazol-5-amine
CBNumber
CB92538270
Molecular Formula
C19H14Cl2N6O
Formula Weight
413.26
MOL File
870061-27-1.mol
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A 839977 Property

Boiling point:
604.9±65.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
solid
pka
2.96±0.12(Predicted)
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4232
Product name
A839977
Purity
≥98%(HPLC)
Packaging
10
Price
$217
Updated
2021/12/16
Tocris
Product number
4232
Product name
A839977
Purity
≥98%(HPLC)
Packaging
50
Price
$851
Updated
2021/12/16
TRC
Product number
A965365
Product name
A839977
Packaging
2.5mg
Price
$195
Updated
2021/12/16
Usbiological
Product number
254483
Product name
A 839977
Packaging
10mg
Price
$466
Updated
2021/12/16
TRC
Product number
A965365
Product name
A839977
Packaging
1mg
Price
$85
Updated
2021/12/16
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A 839977 Chemical Properties,Usage,Production

Uses

A 839977 is a selective P2X7 receptor antagonist.

Biological Activity

a839977 is a novel and selective antagonist of p2x7 receptor with the ic50 values of 20 nm, 42nm and 150nm for human, rat and mouse, respectively [1].a839977 has been reported to block bzatp-evoked changes in intracellular calcium concentrations in 132n1 cells stable expressing p2x7 receptors with the ic50 values of 20 nm, 42nm and 150nm for human, rat and mouse, respectively. in addition, a839977 has also revealed to inhibit bzatp-stimulated il-1β release and yo-pro uptake with the ic50 of 37nm and 7nm, respectively, in differentiated human thp-1 cells. besides, a839977 has been noted to produce parallel rightward shifts in bzatp concentration-effect calcium influx curves with the paα value of 8.1. apart from these, a839977 has been exhibited to reduce cfa-induced thermal hyperalgesia in a dose-dependent fashion with the ed50 value of 100μmol/kg(i.p.) [1].

storage

Store at +4°C

References

[1] honore p1, donnelly-roberts d, namovic m, zhong c, wade c, chandran p, zhu c, carroll w, perez-medrano a, iwakura y, jarvis mf. the antihyperalgesic activity of a selective p2x7 receptor antagonist, a-839977, is lost in il-1alphabeta knockout mice. behav brain res. 2009 dec 1;204(1):77-81.

A 839977 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 839977 Suppliers

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870061-27-1, A 839977Related Search:


  • A 839977
  • 1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]Methyl]-1H-tetrazol-5-aMine
  • 1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine
  • 1-(2,3-dichlorophenyl)-N-[(2-pyridin-2-yloxyphenyl)methyl]tetrazol-5-amine
  • 1-(2,3-dichlorophenyl)-n-[2-(2-pyridinyloxy)benzyl]-1h-tetrazol-5 -amine
  • A839977 1-(2,3-dichlorophenyl)-N-{[2-(pyridin-2-yloxy)phenyl]methyl}-1H-1,2,3,4-tetrazol-5-amine
  • ACHEMBLOCK F-4551
  • 1-(2,3-DICHLOROPHENYL)-N-{[2-(PYRIDIN-2-YLOXY)PHENYL]METHYL}-1H-1,2,3,4-TETRAZOL-5-AMINE
  • 1H-Tetrazol-5-amine, 1-(2,3-dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-
  • 870061-27-1
  • C19H14Cl2N6O