A 839977

Product Name: A 839977
CAS No.: 870061-27-1
Chemical Name: A 839977
Synonyms: A 839977;ACHEMBLOCK F-4551;1-(2,3-Dichlorophenyl)-N-(2-(pyridin-2-yloxy)benzyl)-1H-tetrazol-5-amine;1-(2,3-dichlorophenyl)-n-[2-(2-pyridinyloxy)benzyl]-1h-tetrazol-5 -amine;1-(2,3-dichlorophenyl)-N-[(2-pyridin-2-yloxyphenyl)methyl]tetrazol-5-amine;1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]Methyl]-1H-tetrazol-5-aMine;1H-Tetrazol-5-amine, 1-(2,3-dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-;1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine;1-(2,3-DICHLOROPHENYL)-N-{[2-(PYRIDIN-2-YLOXY)PHENYL]METHYL}-1H-1,2,3,4-TETRAZOL-5-AMINE;A839977 1-(2,3-dichlorophenyl)-N-{[2-(pyridin-2-yloxy)phenyl]methyl}-1H-1,2,3,4-tetrazol-5-amine
CBNumber: CB92538270
Molecular Formula: C19H14Cl2N6O
Formula Weight: 413.26
MOL File: 870061-27-1.mol

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A 839977 Property

Boiling point:: 604.9±65.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solid
pka: 2.96±0.12(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4232
Product name: A839977
Purity: ≥98%(HPLC)
Packaging: 10
Price: $217
Updated: 2021/12/16

Tocris

Product number: 4232
Product name: A839977
Purity: ≥98%(HPLC)
Packaging: 50
Price: $851
Updated: 2021/12/16

TRC

Product number: A965365
Product name: A839977
Packaging: 1mg
Price: $85
Updated: 2021/12/16

TRC

Product number: A965365
Product name: A839977
Packaging: 2.5mg
Price: $195
Updated: 2021/12/16

Usbiological

Product number: 254483
Product name: A 839977
Packaging: 10mg
Price: $466
Updated: 2021/12/16

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A 839977 Chemical Properties,Usage,Production

Uses

A 839977 is a selective P2X7 receptor antagonist.

Biological Activity

a839977 is a novel and selective antagonist of p2x7 receptor with the ic50 values of 20 nm, 42nm and 150nm for human, rat and mouse, respectively [1].a839977 has been reported to block bzatp-evoked changes in intracellular calcium concentrations in 132n1 cells stable expressing p2x7 receptors with the ic50 values of 20 nm, 42nm and 150nm for human, rat and mouse, respectively. in addition, a839977 has also revealed to inhibit bzatp-stimulated il-1β release and yo-pro uptake with the ic50 of 37nm and 7nm, respectively, in differentiated human thp-1 cells. besides, a839977 has been noted to produce parallel rightward shifts in bzatp concentration-effect calcium influx curves with the paα value of 8.1. apart from these, a839977 has been exhibited to reduce cfa-induced thermal hyperalgesia in a dose-dependent fashion with the ed50 value of 100μmol/kg(i.p.) [1].

storage

Store at +4°C

References

[1] honore p1, donnelly-roberts d, namovic m, zhong c, wade c, chandran p, zhu c, carroll w, perez-medrano a, iwakura y, jarvis mf. the antihyperalgesic activity of a selective p2x7 receptor antagonist, a-839977, is lost in il-1alphabeta knockout mice. behav brain res. 2009 dec 1;204(1):77-81.

A 839977 Preparation Products And Raw materials

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Preparation Products

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A 839977 Suppliers

China 39 United Kingdom 2 United States 9 Global 50

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870061-27-1, A 839977Related Search:

A 839977

1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]Methyl]-1H-tetrazol-5-aMine

1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine

1-(2,3-dichlorophenyl)-N-[(2-pyridin-2-yloxyphenyl)methyl]tetrazol-5-amine

1-(2,3-dichlorophenyl)-n-[2-(2-pyridinyloxy)benzyl]-1h-tetrazol-5 -amine

A839977 1-(2,3-dichlorophenyl)-N-{[2-(pyridin-2-yloxy)phenyl]methyl}-1H-1,2,3,4-tetrazol-5-amine

ACHEMBLOCK F-4551

1-(2,3-DICHLOROPHENYL)-N-{[2-(PYRIDIN-2-YLOXY)PHENYL]METHYL}-1H-1,2,3,4-TETRAZOL-5-AMINE

1H-Tetrazol-5-amine, 1-(2,3-dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-

1-(2,3-Dichlorophenyl)-N-(2-(pyridin-2-yloxy)benzyl)-1H-tetrazol-5-amine

870061-27-1

C19H14Cl2N6O