ChemicalBook > CAS DataBase List > 2,5-DiMethyl Celecoxib

2,5-DiMethyl Celecoxib

Product Name
2,5-DiMethyl Celecoxib
CAS No.
457639-26-8
Chemical Name
2,5-DiMethyl Celecoxib
Synonyms
Celecoxib-13;5-dimethyl Celecoxib;Celecoxib Impurity K;Celecoxib impurity T;Celecoxib Impurity 42;Celecoxib 2,5-Dimethyl;2,5-DiMethyl Celecoxib;2,5-DiMethyl-celecoxib DMC;2,5dimethyl Celecoxib,2,5 dimethyl Celecoxib;4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
CBNumber
CB92543122
Molecular Formula
C18H16F3N3O2S
Formula Weight
395.4
MOL File
457639-26-8.mol
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2,5-DiMethyl Celecoxib Property

Melting point:
>138°C (dec.)
Boiling point:
516.7±60.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: soluble20mg/mL, clear
pka
9.67±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D7196
Product name
2,5-Dimethyl-celecoxib
Purity
≥98% (HPLC)
Packaging
5mg
Price
$40
Updated
2024/03/01
Sigma-Aldrich
Product number
35342
Product name
2,5-Dimethyl-celecoxib
Purity
VETRANAL , analytical standard
Packaging
10mg
Price
$134
Updated
2021/12/16
Cayman Chemical
Product number
10008006
Product name
2,5-dimethyl Celecoxib
Packaging
5mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
10008006
Product name
2,5-dimethyl Celecoxib
Packaging
10mg
Price
$92
Updated
2024/03/01
Sigma-Aldrich
Product number
D7196
Product name
2,5-Dimethyl-celecoxib
Purity
≥98% (HPLC)
Packaging
25mg
Price
$407
Updated
2024/03/01
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2,5-DiMethyl Celecoxib Chemical Properties,Usage,Production

Uses

2,5-Dimethyl-celecoxib has been used

  • To block the synthesis of prostaglandin E2 and to study effect of transforming growth factor-2 signaling towards cyclooxygenase-2 expression.
  • In an in vitro study to analyze its pro-oxidative capacities in metastatic melanoma/ breast cancer cells.
  • To study its interaction between silymarin on chemically induced osteoarthritis in rats.

Uses

A non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.

Biochem/physiol Actions

Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

storage

Room temperature

2,5-DiMethyl Celecoxib Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-DiMethyl Celecoxib Suppliers

Canada 1 China 53 India 2 The Netherlands 1 United Kingdom 2 United States 10 Global 69
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457639-26-8, 2,5-DiMethyl CelecoxibRelated Search:


  • 4-[5-(2,5-DiMethylphenyl)-3-(trifluoroMethyl)-1H-pyrazol-1-yl]benzenesulfonaMide
  • 2,5-DiMethyl-celecoxib DMC
  • 2,5-Dimethylcelecoxib 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
  • 2,5-DiMethyl Celecoxib
  • 4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
  • Celecoxib-13
  • Celecoxib Impurity 42
  • Celecoxib Impurity K
  • Celecoxib 2,5-Dimethyl
  • Benzenesulfonamide, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-
  • 5-dimethyl Celecoxib
  • Celecoxib impurity T
  • 2,5dimethyl Celecoxib,2,5 dimethyl Celecoxib
  • 457639-26-8
  • Amines
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds