Azilsartan kaMedoxoMil

ChemicalBook > CAS DataBase List > Azilsartan kaMedoxoMil

Azilsartan kaMedoxoMil

Product Name: Azilsartan kaMedoxoMil
CAS No.: 863031-24-7
Chemical Name: Azilsartan kaMedoxoMil
Synonyms: TAK 491 kamedoxomil;TAK-491 monopotassium;Azilsartan kaMedoxoMil;Azilsartan KaModoxoMil;Azilsartan KaMedoximil;Azilsartan Mehtyl ester;AZILSARTAN KAMEDOXOMIL IH;Azilsartan MedoxMil PotassuiM;Azilsartan Medoxomil Potassium;Azilsartan MedoxiMil PotassiuM
CBNumber: CB92549391
Molecular Formula: C30H25KN4O8
Formula Weight: 608.65
MOL File: 863031-24-7.mol

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Azilsartan kaMedoxoMil Property

Melting point:: 193 - 195°C
storage temp.: Refrigerator, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChIKey: URRUOGRYFYNQJO-UHFFFAOYSA-N
SMILES: C(C1C=CC(C2C=CC=CC=2C2=NOC(=O)N2)=CC=1)N1C(=NC2=CC=CC(C(=O)OCC3=C(OC(=O)O3)C)=C12)OCC.[KH]

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A965605
Product name: AzilsartanKamedoxomil(>90%)
Packaging: 250mg
Price: $425
Updated: 2021/12/16

Usbiological

Product number: 260001
Product name: Azilsartan medoxomil potassium
Packaging: 250mg
Price: $701
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb146200
Product name: Azilsartan kamedoxomil
Purity: >98%
Packaging: 250mg
Price: $912.9
Updated: 2021/12/16

ApexBio Technology

Product number: B1071
Product name: Azilsartanmedoxomilmonopotassium
Packaging: 50mg
Price: $1347
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb146200
Product name: Azilsartan kamedoxomil
Purity: >98%
Packaging: 1g
Price: $1802
Updated: 2021/12/16

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Azilsartan kaMedoxoMil Chemical Properties,Usage,Production

Uses

Azilsartan Kamedoxomil is an angiotensin II receptor blocker.

Definition

ChEBI: Azilsartan kamedoxomil is an organic potassium salt that is the monopotassium salt of azilsartan medoxomil. A prodrug for azilsartan, it is used for treatment of hypertension. It has a role as a prodrug, an antihypertensive agent and an angiotensin receptor antagonist. It contains an azilsartan medoxomil(1-).

Clinical Use

Azilsartan kamedoxomil, developed by Takeda Pharmaceuticals, was approved for the treatment of hypertension and launched in the U.S. under the brand name Edarbi. Edarbi is a prodrug that undergoes rapid hydrolysis to liberate azilsartan, the active ingredient (TAK-536, 39). As the 8th angiotensin receptor blocker (ARB) to enter the world market, azilsartan kamedoxomil can function as monotherapy or in combination with other antihypertensive agents. In several clinical studies, monotherapeutic azilsartan kamedoxomil showed superior antihypertensive activity and a favorable safety/tolerability profile in patients compared with other established therapeutics, including valsartan, olmesartan medoxomil, candesartan, and telmisartan.In late 2011,Takeda announced that FDA also approved the fixed-dose combination tablet of azilsartan kamedoxomil with chlorthalidone under the trade name of Edarbyclor.

Synthesis

Based on the synthesis of azilsartan, the process-scale approach to azilsartan kamedoxomil is described in the scheme. The synthesis started with commercially available methyl 2-[(tert-butoxycarbonyl)amino]-3-nitrobenzoate (30), which can also be prepared by several different routes.41,42 Alkylation of 30 with diaryl bromide 31 gave benzylamine 32 in 78% yield, which was followed by deprotection with 30% ethanolic HCl and alkalinization to produce amine 33 in 77% yield. The nitro group within 33 was reduced with hydrazine hydrate and a catalytic amount of ferric chloride to afford 2,3-diaminobenzoate 34 in 64% yield. Ring formation was achieved by treatment of 34 with tetraethoxymethane and acetic acid to produce benzimidazole 35 in 91% yield.37 The addition of hydroxylamine to the cyano group of 35 provided amidoxime 36 in 55% yield, which underwent immediate cyclization upon treatment with 2-ethylhexyl chloroformate 37 in refluxing xylenes to give oxadiazolone 38 in 52% yield. Hydrolysis of 38 gave azilsartan (39, TAK-536) in 94% yield. In the presence of perchlorobenzoyl chloride 40 and triethylamine, carboxylic acid 39 was converted to the mixed acid anhydride intermediate, which when condensed with alcohol 41 furnished benzoate 42 in 50% yield. Salt preparation of 42 was accomplished with potassium 2-ethylhexyl carboxylate 43 affording azilsartan kamedoxomil (V) in 63% yield.

Azilsartan kaMedoxoMil Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Azilsartan kaMedoxoMil manufacturers

Moxin Chemicals

Product: Azilsartan Impurity 113 863031-24-7
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 100000000
Release date: 2024-12-13

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Azilsartan Impurity 113 863031-24-7
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-06-04

Xuchang Hengsheng Pharmaceutical Co., Ltd

Product: Azilsartan Kamedoxomil 863031-24-7
Price: US $0.00/Kg
Min. Order: 1Kg
Purity: ≥99.0%
Supply Ability: 10 Tons
Release date: 2024-08-07

863031-24-7, Azilsartan kaMedoxoMilRelated Search:

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester (Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate Azilsartan Medoxomil Azilsartan

Azilsartan kaMedoxoMil

1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester potassium salt

Azilsartan MedoxoMil PotassiuM salt

Azilsartan MedoxoMil (MonopotassiuM salt)

Azilsartan MedoxoMil (MonopotassiuM)

Azilsartan MedoxiMil PotassiuM

Azilsartan KaModoxoMil

Azilsartan kaMedoxoMil (with 5 ints.)

Azilsartan MedoxMil PotassuiM

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester, potassiuM salt

Azilsartan Medoxomil Potassium

Azilsartan Mehtyl ester

Azilsartan Impurity 50 Potassium Salt

Azilsartan medoxomil monopotassium (TAK 491)

Azilsartan KaMedoximil

Azilsartan Medoxomil Potassium Crude

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, potassium salt

TAK 491 kamedoxomil

TAK-491 monopotassium

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, potassium salt

Potassium 3-(4'-((2-ethoxy-7-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-5-oxo-5H-1,2,4-oxadiazol-2-ide

AZILSARTAN KAMEDOXOMIL IH

Azilsartan Impurity 60 Potassium Salt

Azilsartan Impurity 45 Potassium Salt

863031-24-7

C30H23KN4O8

C30H23N4O8K

Azilsartan Kamedoxomil

863031-24-7