Nortadalafil
- Product Name
- Nortadalafil
- CAS No.
- 171596-36-4
- Chemical Name
- Nortadalafil
- Synonyms
- Nortadalafil;4-b]indole-1;(6R-trans)-6-(1;DeMethyltadalafil;N-demethyltadalafil;Tadalafil IMpurity J;N-DesMethyl Tadalafil;Tadalafil Impurity 21;N-Demethyl Tildenafil;Tildenafil Impurity 7
- CBNumber
- CB92549609
- Molecular Formula
- C21H17N3O4
- Formula Weight
- 375.38
- MOL File
- 171596-36-4.mol
Nortadalafil Property
- Melting point:
- 285-290℃ (methanol )
- Boiling point:
- 718.6±60.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 13.53±0.40(Predicted)
- color
- White to Pale Yellow
- InChI
- InChI=1S/C21H17N3O4/c25-18-9-22-21(26)15-8-13-12-3-1-2-4-14(12)23-19(13)20(24(15)18)11-5-6-16-17(7-11)28-10-27-16/h1-7,15,20,23H,8-10H2,(H,22,26)/t15-,20-/m1/s1
- InChIKey
- XHDLVMPUSXRZOS-FOIQADDNSA-N
- SMILES
- N1C2=C(C=CC=C2)C2C[C@]3([H])C(=O)NCC(=O)N3[C@H](C3=CC=C4OCOC4=C3)C1=2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D293800
- Product name
- N-DesmethylTadalafil
- Packaging
- 5mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FD21326
- Product name
- N-Desmethyl tadalafil
- Packaging
- 1mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0823
- Product name
- Nortadalafil
- Purity
- 99.69%
- Packaging
- 5mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- FD21326
- Product name
- N-Desmethyl tadalafil
- Packaging
- 2mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- A3665
- Product name
- Nortadalafil
- Packaging
- 2mg
- Price
- $156
- Updated
- 2021/12/16
Nortadalafil Chemical Properties,Usage,Production
Uses
A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil (T004500). A potential antiplasmodial drug.
Biological Activity
the cgmp-specific pde5 is the major pde isozyme in the corpus cavernosum, and controls penile erection. the pde5 inhibitors used in the clinic amplify the no-ccmp pathway and enhance the normal process leading to penile erection.nortadalafil is demethyl tadalafil, which is a pde5 inhibitor currently marketed in pill form for treating erectile dysfunction under the name cialis and for the treatment of pulmonary arterial hypertension under the name adcirca.
in vitro
tadalafil has been identified as a highly potent pde5 inhibitor (ic50 = 5 nm) with high selectivity for pde5 vs pde1-4 and pde6. it displays 85-fold greater selectivity vs pde6 than sildenafil [1].
in vivo
tadalafil showed profound and long-lasting blood pressure lowering activity (30 mmhg/>7 h) in the spontaneously hypertensive rat model after oral administration (5 mg/kg) [1].
target
PDE5
IC 50
n/a for nortadalafil; 5 nm for tadalafil
References
[1] daugan a, grondin p, ruault c, le monnier de gouville ac, coste h, linget jm, kirilovsky j, hyafil f, labaudinière r. the discovery of tadalafil: a novel and highly selective pde5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. j med chem. 2003;46(21):4533-42.
[2] porst h, hell-momeni k, büttner h. chronic pde-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. expert opin pharmacother. 2012 jul;13(10):1481-94. doi: 10.1517/14656566.2012.693162.
Nortadalafil Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Nortadalafil manufacturers
- Product
- Nortadalafil 171596-36-4
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2025-10-14
- Product
- Nortadalafil 171596-36-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%
- Supply Ability
- 500kg
- Release date
- 2025-08-28
- Product
- Nortadalafil 171596-36-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500 kg
- Release date
- 2025-04-16