Nortadalafil

Product Name: Nortadalafil
CAS No.: 171596-36-4
Chemical Name: Nortadalafil
Synonyms: Nortadalafil;DeMethyltadalafil;N-demethyltadalafil;Tadalafil IMpurity J;N-DesMethyl Tadalafil;Tadalafil Impurity 21;Demethyltadalafil impurity;Tadalafil IMpurity:IMpurity C;Tadanafil N-desmethyl impurity;Nortadalafil/Demethyl Tadalafil
CBNumber: CB92549609
Molecular Formula: C21H17N3O4
Formula Weight: 375.38
MOL File: 171596-36-4.mol

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Nortadalafil Property

Melting point:: 285-290℃ (methanol )
Boiling point:: 718.6±60.0 °C(Predicted)
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 13.53±0.40(Predicted)
color: White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D293800
Product name: N-DesmethylTadalafil
Packaging: 5mg
Price: $185
Updated: 2021/12/16

ApexBio Technology

Product number: A3665
Product name: Nortadalafil
Packaging: 5mg
Price: $213
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21326
Product name: N-Desmethyl tadalafil
Packaging: 5mg
Price: $285
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010360
Product name: NORTADALAFIL
Purity: 95.00%
Packaging: 5MG
Price: $322.3
Updated: 2021/12/16

ApexBio Technology

Product number: A3665
Product name: Nortadalafil
Packaging: 10mg
Price: $331
Updated: 2021/12/16

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Nortadalafil Chemical Properties,Usage,Production

Uses

A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil (T004500). A potential antiplasmodial drug.

Biological Activity

the cgmp-specific pde5 is the major pde isozyme in the corpus cavernosum, and controls penile erection. the pde5 inhibitors used in the clinic amplify the no-ccmp pathway and enhance the normal process leading to penile erection.nortadalafil is demethyl tadalafil, which is a pde5 inhibitor currently marketed in pill form for treating erectile dysfunction under the name cialis and for the treatment of pulmonary arterial hypertension under the name adcirca.

in vitro

tadalafil has been identified as a highly potent pde5 inhibitor (ic50 = 5 nm) with high selectivity for pde5 vs pde1-4 and pde6. it displays 85-fold greater selectivity vs pde6 than sildenafil [1].

in vivo

tadalafil showed profound and long-lasting blood pressure lowering activity (30 mmhg/>7 h) in the spontaneously hypertensive rat model after oral administration (5 mg/kg) [1].

target

PDE5

IC 50

n/a for nortadalafil; 5 nm for tadalafil

References

[1] daugan a, grondin p, ruault c, le monnier de gouville ac, coste h, linget jm, kirilovsky j, hyafil f, labaudinière r. the discovery of tadalafil: a novel and highly selective pde5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. j med chem. 2003;46(21):4533-42.
[2] porst h, hell-momeni k, büttner h. chronic pde-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. expert opin pharmacother. 2012 jul;13(10):1481-94. doi: 10.1517/14656566.2012.693162.

Nortadalafil Preparation Products And Raw materials

Raw materials

Preparation Products

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Nortadalafil Suppliers

Canada 1 China 115 India 3 United Kingdom 1 United States 12 Global 132

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

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View Lastest Price from Nortadalafil manufacturers

Jiangsu Monade Biological Technology Co., Ltd.

Product: Nortadalafil 171596-36-4
Price: US $0.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99.99
Supply Ability: 10000
Release date: 2021-09-10

Career Henan Chemical Co

Product: Nortadalafil 171596-36-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-01-02

171596-36-4, NortadalafilRelated Search:

Tetryzoline (1R,3R)-2-acetyl-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro- 1H-pyrido[3,4-b]indole-3-carboxylate (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1S,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylic Acid Methyl Ester 2-Hydroxypropyl Nortadalafil cis-ent-Tadalafil (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(dimethylglycyl)-2,3,4,9-tetrahydro-1H-pyrido [3,4-b]indole-3-carboxylate methyl (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester Chloropretadalafil cis-Tadalafil D(+)-Tryptophan Tadalafil iMpurity B Tadalafil KetolactaM Tadalafil JLEQLXGZAIAEFX-VRQJEYPFSA-N Tadalafil EP Impurity

DeMethyltadalafil

N-DesMethyl Tadalafil

(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Tadalafil Impurity 21

(6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Nortadalafil

Tadalafil IMpurity:IMpurity C

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)-

(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, N-DesMethyl Tadalafil

Tadalafil IMpurity J

Tadanafil N-desmethyl impurity

Tetrahydropalmatine Solution, 100ppm

Tadalafil Impurity 21(N-Desmethyl Tadalafil)

Nortadalafil Solution in Methanol, 100μg/mL

N-demethyltadalafil

(6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione? (Tadalafil Impurity)

(6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Nortadalafil/Demethyl Tadalafil

N-Desmethyl tadalafil in methanol

(6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Demethyltadalafil impurity

171596-36-4

172596-36-4

Aromatics

Drug Analogues

Heterocycles

Indole Derivatives

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals