ChemicalBook > CAS DataBase List > 1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product Name
1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.
1151802-22-0
Chemical Name
1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Synonyms
1-cyc;1-Cyclopropyl-4-(pinacolylboronate)-pyrazole;1-cyclopropylpyrazole-4-boronic acid pinacol ester;1-Cyclopropyl-1H-pyrazole-4-boronic acid pinacol ester;1-Cyclopropyl-1H-pyrazole-4-boronicacidpinacolester,97%;(1-CYCLOPROPYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER;1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);1-cyclopropyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CBNumber
CB92550245
Molecular Formula
C12H19BN2O2
Formula Weight
234.1
MOL File
1151802-22-0.mol
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1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Property

Boiling point:
354.3±15.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
3.33±0.12(Predicted)
form 
Solid
Appearance
White to off-white Solid
InChI
InChI=1S/C12H19BN2O2/c1-11(2)12(3,4)17-13(16-11)9-7-14-15(8-9)10-5-6-10/h7-8,10H,5-6H2,1-4H3
InChIKey
NLWYVKHISUTBMY-UHFFFAOYSA-N
SMILES
N1(C2CC2)C=C(B2OC(C)(C)C(C)(C)O2)C=N1
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Safety

WGK Germany 
3
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00115
Product name
1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity
Aldrich
Packaging
1g
Price
$1510
Updated
2025/07/31
TRC
Product number
C988190
Product name
1-Cyclopropyl-4-(pinacolylboronate)-pyrazole
Packaging
250mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-W000818
Product name
1-cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity
≥97.0%
Packaging
1g
Price
$94
Updated
2021/12/16
Apolloscientific
Product number
OR313025
Product name
(1-Cyclopropyl-1H-pyrazol-4-yl)boronicacid,pinacolester
Purity
95%
Packaging
1g
Price
$141
Updated
2021/12/16
SynQuest Laboratories
Product number
8H60-1-7B
Product name
1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging
1g
Price
$156
Updated
2021/12/16
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1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties,Usage,Production

Chemical Properties

Type of white solid

Uses

1-Cyclopropyl-4-(pinacolylboronate)-pyrazole is a triazolopyridazine compound with the potential to be used in the treatment of cancer, acting as an c-Met kinase inhibitor.

Synthesis

61676-62-8

1239363-40-6

1151802-22-0

Step 2: In a dry flask, 1-cyclopropyl-4-iodo-1H-pyrazole (405 mg, 1.73 mmol) was dissolved in anhydrous THF (8.0 mL) and the solution was cooled to 0 °C. Under nitrogen protection, isopropylmagnesium chloride solution (2.0 M in THF, 1.04 mL, 2.08 mmol) was slowly added dropwise, keeping the reaction temperature at 0 °C. After the dropwise addition, the reaction mixture was stirred at 0 °C for 45 min. Subsequently, 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (0.53 mL, 2.60 mmol) was added and the reaction mixture was allowed to warm up slowly to room temperature over 1 hour. Upon completion of the reaction, the reaction was quenched with 50% saturated aqueous NH4Cl and extracted with EtOAc. The organic phases were combined, washed with saturated aqueous NaCl, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 20-50% EtOAc/heptane) to afford 405 mg (83% yield) of 1-cyclopropyl-1H-pyrazole-4-boronic acid pinacol ester as a colorless viscous oil.

References

[1] Patent: US2011/230462, 2011, A1. Location in patent: Page/Page column 84

1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Suppliers

China 124 India 2 United Kingdom 1 United States 15 Global 142
Shanghai Youmede Technology Co., LTD
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18964944463
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
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21-57721279
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Pure Chemistry Scientific Inc.
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Accela ChemBio Co.,Ltd.
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shanghai Rainbow MediTech.Co.Ltd.
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021-64968085,64968086-5815,5812; 13472757003
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+86 21 64968087
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View Lastest Price from 1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1151802-22-0
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-07-05
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1151802-22-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1151802-22-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

1151802-22-0, 1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleRelated Search:

1-cyclopropyl-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 1-CYCLOPENTYL-PIPERIDIN-3-ONE 1-CYCLOPROPYLMETHYL-PIPERAZINE DIHYDROCHLORIDE 1-Cyclohexyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Cyclopropyl-4-iodo-1H-pyrazole Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride 1,3,2-dioxaborolane,2-(4-fluoro-2-nitrophenyl)-4,4,5,5-tetraMethyl- 2-TERT-BUTYLOXYCARBONYLAMINOPYRIDINE-3-BORONIC ACID PINACOL ESTER (2-[(TERT-BUTOXYCARBONYL)AMINO]PYRIDIN-3-YL)BORONIC ACID

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  • 1-Cyclopropyl-1H-pyrazole-4-boronic acid pinacol ester
  • 1H-Pyrazole, 1-cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
  • 1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
  • 1-cyclopropylpyrazole-4-boronic acid pinacol ester
  • (1-CYCLOPROPYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER
  • 1-cyc
  • 1-Cyclopropyl-4-(pinacolylboronate)-pyrazole
  • 1-cyclopropyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
  • 1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
  • 1-Cyclopropyl-1H-pyrazole-4-boronicacidpinacolester,97%
  • 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-cyclopropyl-1H-pyrazole
  • 1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - [C6537]
  • 1151802-22-0