1-Cyclopropyl-4-iodo-1H-pyrazole

Product Name: 1-Cyclopropyl-4-iodo-1H-pyrazole
CAS No.: 1239363-40-6
Chemical Name: 1-Cyclopropyl-4-iodo-1H-pyrazole
Synonyms: 1-CYCLOPROPYL-4-IODOPYRAZOLE;1-Cyclopropyl-4-iodo-1H-pyrazole;1H-Pyrazole, 1-cyclopropyl-4-iodo-
CBNumber: CB02663821
Molecular Formula: C6H7IN2
Formula Weight: 234.04
MOL File: 1239363-40-6.mol

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1-Cyclopropyl-4-iodo-1H-pyrazole Property

storage temp.: 2-8°C(protect from light)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C6H7IN2/c7-5-3-8-9(4-5)6-1-2-6/h3-4,6H,1-2H2
InChIKey: JBWOMLVMUQFTFQ-UHFFFAOYSA-N
SMILES: N1(C2CC2)C=C(I)C=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C997810
Product name: 1-Cyclopropyl-4-iodo-1H-pyrazole
Packaging: 50mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-0037329
Product name: 1-Cyclopropyl-4-iodo-1H-pyrazole
Packaging: 250mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0037329
Product name: 1-Cyclopropyl-4-iodo-1H-pyrazole
Packaging: 1g
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 115742
Product name: 1-Cyclopropyl-4-iodo-1H-pyrazole
Purity: 95+%
Packaging: 500mg
Price: $269
Updated: 2021/12/16

Matrix Scientific

Product number: 115742
Product name: 1-Cyclopropyl-4-iodo-1H-pyrazole
Purity: 95+%
Packaging: 1g
Price: $378
Updated: 2021/12/16

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1-Cyclopropyl-4-iodo-1H-pyrazole Chemical Properties,Usage,Production

Uses

1-Cyclopropyl-4-iodo-1H-pyrazole is a useful chemical for the preparation of dihydropyridinone MGAT2 inhibitor.

Synthesis

3469-69-0

411235-57-9

1239363-40-6

Synthesis of 1-cyclopropyl-4-iodo-1H-pyrazole: 4-iodo-1H-pyrazole (645 mg, 3.33 mmol), cyclopropylboronic acid (571 mg, 6.65 mmol), copper(II) acetate (604 mg, 3.33 mmol), and DMAP (1219 mg, 9.98 mmol) were dissolved in dioxane (10 mL) and added with 0.323 mL (3.99 mmol) of pyridine. The reaction mixture was heated to 100 °C in air for 16 hours. After completion of the reaction, the mixture was concentrated in vacuum and diluted with EtOAc. The organic layer was washed with 1 M HCl and subsequently dried with MgSO4, filtered and concentrated in vacuum. The crude product was purified by column chromatography to afford Intermediate 10A (660 mg, 2.82 mmol, 85% yield) as a light yellow liquid.LCMS analysis: calculated value for C6H7N2 was 234.04 and measured value [M + H] was 234.9.

References

[1] Patent: WO2015/134701, 2015, A1. Location in patent: Page/Page column 58
[2] Patent: US2011/230462, 2011, A1. Location in patent: Page/Page column 84

1-Cyclopropyl-4-iodo-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Cyclopropyl-4-iodo-1H-pyrazole Suppliers

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1239363-40-6