ChemicalBook > CAS DataBase List > 1-Cyclopropyl-4-iodo-1H-pyrazole

1-Cyclopropyl-4-iodo-1H-pyrazole

Product Name
1-Cyclopropyl-4-iodo-1H-pyrazole
CAS No.
1239363-40-6
Chemical Name
1-Cyclopropyl-4-iodo-1H-pyrazole
Synonyms
1-CYCLOPROPYL-4-IODOPYRAZOLE;1-Cyclopropyl-4-iodo-1H-pyrazole;1H-Pyrazole, 1-cyclopropyl-4-iodo-
CBNumber
CB02663821
Molecular Formula
C6H7IN2
Formula Weight
234.04
MOL File
1239363-40-6.mol
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1-Cyclopropyl-4-iodo-1H-pyrazole Property

storage temp. 
2-8°C(protect from light)
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C6H7IN2/c7-5-3-8-9(4-5)6-1-2-6/h3-4,6H,1-2H2
InChIKey
JBWOMLVMUQFTFQ-UHFFFAOYSA-N
SMILES
N1(C2CC2)C=C(I)C=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C997810
Product name
1-Cyclopropyl-4-iodo-1H-pyrazole
Packaging
50mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-0037329
Product name
1-Cyclopropyl-4-iodo-1H-pyrazole
Packaging
250mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-0037329
Product name
1-Cyclopropyl-4-iodo-1H-pyrazole
Packaging
1g
Price
$130
Updated
2021/12/16
Matrix Scientific
Product number
115742
Product name
1-Cyclopropyl-4-iodo-1H-pyrazole
Purity
95+%
Packaging
500mg
Price
$269
Updated
2021/12/16
Matrix Scientific
Product number
115742
Product name
1-Cyclopropyl-4-iodo-1H-pyrazole
Purity
95+%
Packaging
1g
Price
$378
Updated
2021/12/16
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1-Cyclopropyl-4-iodo-1H-pyrazole Chemical Properties,Usage,Production

Uses

1-Cyclopropyl-4-iodo-1H-pyrazole is a useful chemical for the preparation of dihydropyridinone MGAT2 inhibitor.

Synthesis

3469-69-0

411235-57-9

1239363-40-6

Synthesis of 1-cyclopropyl-4-iodo-1H-pyrazole: 4-iodo-1H-pyrazole (645 mg, 3.33 mmol), cyclopropylboronic acid (571 mg, 6.65 mmol), copper(II) acetate (604 mg, 3.33 mmol), and DMAP (1219 mg, 9.98 mmol) were dissolved in dioxane (10 mL) and added with 0.323 mL (3.99 mmol) of pyridine. The reaction mixture was heated to 100 °C in air for 16 hours. After completion of the reaction, the mixture was concentrated in vacuum and diluted with EtOAc. The organic layer was washed with 1 M HCl and subsequently dried with MgSO4, filtered and concentrated in vacuum. The crude product was purified by column chromatography to afford Intermediate 10A (660 mg, 2.82 mmol, 85% yield) as a light yellow liquid.LCMS analysis: calculated value for C6H7N2 was 234.04 and measured value [M + H] was 234.9.

References

[1] Patent: WO2015/134701, 2015, A1. Location in patent: Page/Page column 58
[2] Patent: US2011/230462, 2011, A1. Location in patent: Page/Page column 84

1-Cyclopropyl-4-iodo-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Cyclopropyl-4-iodo-1H-pyrazole Suppliers

CHINA 65 India 1 United States 4 Global 70
A.J Chemicals
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
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1239363-40-6, 1-Cyclopropyl-4-iodo-1H-pyrazoleRelated Search:

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