ChemicalBook > CAS DataBase List > 1-Cyclopropyl-4-iodo-1H-pyrazole
1-Cyclopropyl-4-iodo-1H-pyrazole
- Product Name
- 1-Cyclopropyl-4-iodo-1H-pyrazole
- CAS No.
- 1239363-40-6
- Chemical Name
- 1-Cyclopropyl-4-iodo-1H-pyrazole
- Synonyms
- 1-CYCLOPROPYL-4-IODOPYRAZOLE;1-Cyclopropyl-4-iodo-1H-pyrazole;1H-Pyrazole, 1-cyclopropyl-4-iodo-
- CBNumber
- CB02663821
- Molecular Formula
- C6H7IN2
- Formula Weight
- 234.04
- MOL File
- 1239363-40-6.mol
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1-Cyclopropyl-4-iodo-1H-pyrazole Property
- storage temp.
- 2-8°C(protect from light)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C6H7IN2/c7-5-3-8-9(4-5)6-1-2-6/h3-4,6H,1-2H2
- InChIKey
- JBWOMLVMUQFTFQ-UHFFFAOYSA-N
- SMILES
- N1(C2CC2)C=C(I)C=N1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C997810
- Product name
- 1-Cyclopropyl-4-iodo-1H-pyrazole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0037329
- Product name
- 1-Cyclopropyl-4-iodo-1H-pyrazole
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0037329
- Product name
- 1-Cyclopropyl-4-iodo-1H-pyrazole
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 115742
- Product name
- 1-Cyclopropyl-4-iodo-1H-pyrazole
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $269
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 115742
- Product name
- 1-Cyclopropyl-4-iodo-1H-pyrazole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $378
- Updated
- 2021/12/16
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1-Cyclopropyl-4-iodo-1H-pyrazole Chemical Properties,Usage,Production
Uses
1-Cyclopropyl-4-iodo-1H-pyrazole is a useful chemical for the preparation of dihydropyridinone MGAT2 inhibitor.
Synthesis
3469-69-0
411235-57-9
1239363-40-6
Synthesis of 1-cyclopropyl-4-iodo-1H-pyrazole: 4-iodo-1H-pyrazole (645 mg, 3.33 mmol), cyclopropylboronic acid (571 mg, 6.65 mmol), copper(II) acetate (604 mg, 3.33 mmol), and DMAP (1219 mg, 9.98 mmol) were dissolved in dioxane (10 mL) and added with 0.323 mL (3.99 mmol) of pyridine. The reaction mixture was heated to 100 °C in air for 16 hours. After completion of the reaction, the mixture was concentrated in vacuum and diluted with EtOAc. The organic layer was washed with 1 M HCl and subsequently dried with MgSO4, filtered and concentrated in vacuum. The crude product was purified by column chromatography to afford Intermediate 10A (660 mg, 2.82 mmol, 85% yield) as a light yellow liquid.LCMS analysis: calculated value for C6H7N2 was 234.04 and measured value [M + H] was 234.9.
References
[1] Patent: WO2015/134701, 2015, A1. Location in patent: Page/Page column 58
[2] Patent: US2011/230462, 2011, A1. Location in patent: Page/Page column 84
1-Cyclopropyl-4-iodo-1H-pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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