1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product Name: 1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.: 1151802-22-0
Chemical Name: 1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Synonyms: 1-cyc;1-Cyclopropyl-4-(pinacolylboronate)-pyrazole;1-cyclopropylpyrazole-4-boronic acid pinacol ester;1-Cyclopropyl-1H-pyrazole-4-boronic acid pinacol ester;1-Cyclopropyl-1H-pyrazole-4-boronicacidpinacolester,97%;(1-CYCLOPROPYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER;1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);1-cyclopropyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CBNumber: CB92550245
Molecular Formula: C12H19BN2O2
Formula Weight: 234.1
MOL File: 1151802-22-0.mol

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1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Property

Boiling point:: 354.3±15.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 3.33±0.12(Predicted)
form: Solid
Appearance: White to off-white Solid
InChI: InChI=1S/C12H19BN2O2/c1-11(2)12(3,4)17-13(16-11)9-7-14-15(8-9)10-5-6-10/h7-8,10H,5-6H2,1-4H3
InChIKey: NLWYVKHISUTBMY-UHFFFAOYSA-N
SMILES: N1(C2CC2)C=C(B2OC(C)(C)C(C)(C)O2)C=N1

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Safety

WGK Germany: 3
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00115
Product name: 1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: Aldrich
Packaging: 1g
Price: $1510
Updated: 2025/07/31

TRC

Product number: C988190
Product name: 1-Cyclopropyl-4-(pinacolylboronate)-pyrazole
Packaging: 250mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-W000818
Product name: 1-cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: ≥97.0%
Packaging: 1g
Price: $94
Updated: 2021/12/16

Apolloscientific

Product number: OR313025
Product name: (1-Cyclopropyl-1H-pyrazol-4-yl)boronicacid,pinacolester
Purity: 95%
Packaging: 1g
Price: $141
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H60-1-7B
Product name: 1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 1g
Price: $156
Updated: 2021/12/16

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1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties,Usage,Production

Chemical Properties

Type of white solid

Uses

1-Cyclopropyl-4-(pinacolylboronate)-pyrazole is a triazolopyridazine compound with the potential to be used in the treatment of cancer, acting as an c-Met kinase inhibitor.

Synthesis

61676-62-8

1239363-40-6

1151802-22-0

Step 2: In a dry flask, 1-cyclopropyl-4-iodo-1H-pyrazole (405 mg, 1.73 mmol) was dissolved in anhydrous THF (8.0 mL) and the solution was cooled to 0 °C. Under nitrogen protection, isopropylmagnesium chloride solution (2.0 M in THF, 1.04 mL, 2.08 mmol) was slowly added dropwise, keeping the reaction temperature at 0 °C. After the dropwise addition, the reaction mixture was stirred at 0 °C for 45 min. Subsequently, 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (0.53 mL, 2.60 mmol) was added and the reaction mixture was allowed to warm up slowly to room temperature over 1 hour. Upon completion of the reaction, the reaction was quenched with 50% saturated aqueous NH4Cl and extracted with EtOAc. The organic phases were combined, washed with saturated aqueous NaCl, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 20-50% EtOAc/heptane) to afford 405 mg (83% yield) of 1-cyclopropyl-1H-pyrazole-4-boronic acid pinacol ester as a colorless viscous oil.

References

[1] Patent: US2011/230462, 2011, A1. Location in patent: Page/Page column 84

1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Suppliers

China 124 India 2 United Kingdom 1 United States 15 Global 142

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

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View Lastest Price from 1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1151802-22-0
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-05

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1151802-22-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1151802-22-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

1151802-22-0, 1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleRelated Search:

1-cyclopropyl-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 1-CYCLOPENTYL-PIPERIDIN-3-ONE 1-CYCLOPROPYLMETHYL-PIPERAZINE DIHYDROCHLORIDE 1-Cyclohexyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Cyclopropyl-4-iodo-1H-pyrazole Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride 1,3,2-dioxaborolane,2-(4-fluoro-2-nitrophenyl)-4,4,5,5-tetraMethyl- 2-TERT-BUTYLOXYCARBONYLAMINOPYRIDINE-3-BORONIC ACID PINACOL ESTER (2-[(TERT-BUTOXYCARBONYL)AMINO]PYRIDIN-3-YL)BORONIC ACID

1-Cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Cyclopropyl-1H-pyrazole-4-boronic acid pinacol ester

1H-Pyrazole, 1-cyclopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)

1-cyclopropylpyrazole-4-boronic acid pinacol ester

(1-CYCLOPROPYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER

1-cyc

1-Cyclopropyl-4-(pinacolylboronate)-pyrazole

1-cyclopropyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

1-Cyclopropyl-1H-pyrazole-4-boronicacidpinacolester,97%

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-cyclopropyl-1H-pyrazole

1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - [C6537]

1151802-22-0