NSC 33994

Product Name: NSC 33994
CAS No.: 82058-16-0
Chemical Name: NSC 33994
Synonyms: G6;NCC27;NSC 33994;4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol};(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylaMino)Methyl]phenol;4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylaMino)Methyl]phenol;Phenol, 4,4'-[(1E)-1,2-diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]-;(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI)
CBNumber: CB92550801
Molecular Formula: C28H42N2O2
Formula Weight: 438.65
MOL File: 82058-16-0.mol

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NSC 33994 Property

Boiling point:: 524.7±45.0 °C(Predicted)
Density: 1.040±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥25mg/mL
form: powder
pka: 9.20±0.50(Predicted)
color: white to tan
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0069
Product name: NSC 33994
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $119
Updated: 2022/05/15

Tocris

Product number: 4338
Product name: NSC 33994
Purity: ≥98%(HPLC)
Packaging: 10
Price: $189
Updated: 2021/12/16

Tocris

Product number: 4338
Product name: NSC 33994
Purity: ≥98%(HPLC)
Packaging: 50
Price: $744
Updated: 2021/12/16

TRC

Product number: N900300
Product name: NSC 33994
Packaging: 500mg
Price: $1145
Updated: 2021/12/16

Usbiological

Product number: 018611
Product name: NSC 33994
Packaging: 50mg
Price: $432
Updated: 2021/12/16

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NSC 33994 Chemical Properties,Usage,Production

Description

NSC-33994 (82058-16-0) is a remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.1?Suppresses JAK2-V617F-mediated human pathological cell growth?in vitro?and?in vivo2?and is concomitant with the disruption of intracellular vimentin filaments3. NSC-33994 reduces the tumorigenic potential of T98G glioblastoma cells?in vitro?and?in vivo.4

Uses

NSC-33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies.

IC 50

JAK2: 60 nM (IC₅₀, JAK2 Val617Phe kinase activity )

storage

-20°C

References

[1] RÓBERT KISS . Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening[J]. Bioorganic & Medicinal Chemistry Letters, 2009, 19 13: Pages 3598-3601. DOI:10.1016/j.bmcl.2009.04.138
[2] ANNET KIRABO. The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo.[J]. The Journal of Biological Chemistry, 2011: 4280-4291. DOI:10.1074/jbc.m110.200774
[3] ANURIMA MAJUMDER. Cell Death Induced by the Jak2 Inhibitor, G6, Correlates with Cleavage of Vimentin Filaments[J]. Biochemistry Biochemistry, 2011, 50 36: 7774-7786. DOI:10.1021/bi200847n
[4] REBEKAH BASKIN. The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.[J]. PLoS ONE, 2014: e105568. DOI:10.1371/journal.pone.0105568

NSC 33994 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC 33994 Suppliers

Canada 1 China 35 United Kingdom 1 United States 10 Global 47

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82058-16-0, NSC 33994Related Search:

TYRPHOSTIN AG 879 ZM 336372 Sunitinib Malate 17-AAG

(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylaMino)Methyl]phenol

4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylaMino)Methyl]phenol

(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI)

4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}

G6

NSC 33994

Phenol, 4,4'-[(1E)-1,2-diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]-

NCC27

82058-16-0

Amines

Aromatics

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Intracellular signaling.