DU-14
- Product Name
- DU-14
- CAS No.
- 186303-55-9
- Chemical Name
- DU-14
- Synonyms
- DU-14;TETRADECANAMIDE, N-[2-[4-[(AMINOSULFONYL)OXY]PHENYL]ETHYL]-
- CBNumber
- CB92551666
- Molecular Formula
- C22H38N2O4S
- Formula Weight
- 426.61
- MOL File
- 186303-55-9.mol
DU-14 Property
- Density
- 1.089±0.06 g/cm3(Predicted)
- storage temp.
- RT
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- pka
- 8.74±0.70(Predicted)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
N-Bromosuccinimide Price
- Product number
- orb545851
- Product name
- DU-14
- Purity
- >98%
- Packaging
- 5mg
- Price
- $173.4
- Updated
- 2021/12/16
- Product number
- orb545851
- Product name
- DU-14
- Purity
- >98%
- Packaging
- 25mg
- Price
- $423.3
- Updated
- 2021/12/16
DU-14 Chemical Properties,Usage,Production
Description
DU-14 (186303-55-9) inhibits steroid sulfatase (IC50=ca. 60 nM). Enhances learning and spatial memory in rats.1 Inhibits proliferation of human MCF-7 breast cancer cells.2
Uses
DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity[1][2][3].
in vivo
DU-14 (30 mg/kg, i.p., once time) inhibits steroid sulfatase activity in both brain and liver tissues and enhances the memory-enhancing properties of DHEAS in rats with scopolamine-induced amnesia[2].
References
[1] DAVID A JOHNSON . The effect of steroid sulfatase inhibition on learning and spatial memory1[J]. Brain Research, 2000, 865 2: Pages 286-290. DOI:10.1016/s0006-8993(00)02372-6
[2] K W SELCER P K L P V Hegde. Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines.[J]. Cancer research, 1997, 57 4: 702-707.
DU-14 Preparation Products And Raw materials
Raw materials
Preparation Products
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