ChemicalBook > CAS DataBase List > ICA 069673

ICA 069673

Product Name
ICA 069673
CAS No.
582323-16-8
Chemical Name
ICA 069673
Synonyms
ICA 069673;ICA069673;ICA-069673;ICA-069673 >=98% (HPLC);N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
CBNumber
CB92552603
Molecular Formula
C11H6ClF2N3O
Formula Weight
269.63
MOL File
582323-16-8.mol
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ICA 069673 Property

Boiling point:
358.9±37.0 °C(Predicted)
Density 
1.539±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)
pka
9.47±0.70(Predicted)
form 
Powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
5mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
10mg
Price
$167
Updated
2024/03/01
Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
25mg
Price
$363
Updated
2024/03/01
Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
50mg
Price
$723
Updated
2024/03/01
Tocris
Product number
4305
Product name
ICA069673
Purity
≥99%(HPLC)
Packaging
25
Price
$386
Updated
2021/12/16
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ICA 069673 Chemical Properties,Usage,Production

Description

ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.

storage

Room temperature

ICA 069673 Preparation Products And Raw materials

Raw materials

Preparation Products

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ICA 069673 Suppliers

China 48 India 1 United Kingdom 1 United States 10 Global 60
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4153
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
9756
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
1014988033@qq.com
Country
China
ProdList
4981
Advantage
55
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3244
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9730
Advantage
58

582323-16-8, ICA 069673Related Search:


  • ICA 069673
  • N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
  • ICA069673;ICA-069673
  • Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-
  • ICA-069673 >=98% (HPLC)
  • Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
  • N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide
  • 582323-16-8
  • C11H6ClF2N3O
  • Selective KCNQ2/Q3 potassium channel opener.