ChemicalBook > CAS DataBase List > ICA 069673

ICA 069673

Product Name
ICA 069673
CAS No.
582323-16-8
Chemical Name
ICA 069673
Synonyms
ICA 069673;ICA069673;ICA-069673;ICA-069673 >=98% (HPLC);N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
CBNumber
CB92552603
Molecular Formula
C11H6ClF2N3O
Formula Weight
269.63
MOL File
582323-16-8.mol
More
Less

ICA 069673 Property

Boiling point:
358.9±37.0 °C(Predicted)
Density 
1.539±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)
pka
9.47±0.70(Predicted)
form 
Powder
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
5mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
10mg
Price
$167
Updated
2024/03/01
Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
25mg
Price
$363
Updated
2024/03/01
Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
50mg
Price
$723
Updated
2024/03/01
Tocris
Product number
4305
Product name
ICA069673
Purity
≥99%(HPLC)
Packaging
25
Price
$386
Updated
2021/12/16
More
Less

ICA 069673 Chemical Properties,Usage,Production

Description

ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.

storage

Room temperature

ICA 069673 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

ICA 069673 Suppliers

China 48 India 1 United Kingdom 1 United States 10 Global 60
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

582323-16-8, ICA 069673Related Search:


  • ICA 069673
  • N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
  • ICA069673;ICA-069673
  • Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-
  • ICA-069673 >=98% (HPLC)
  • Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
  • N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide
  • 582323-16-8
  • C11H6ClF2N3O
  • Selective KCNQ2/Q3 potassium channel opener.