ChemicalBook > CAS DataBase List > ICA 069673

ICA 069673

Product Name
ICA 069673
CAS No.
582323-16-8
Chemical Name
ICA 069673
Synonyms
ICA 069673;ICA069673;ICA-069673;ICA-069673 >=98% (HPLC);N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
CBNumber
CB92552603
Molecular Formula
C11H6ClF2N3O
Formula Weight
269.63
MOL File
582323-16-8.mol
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ICA 069673 Property

Boiling point:
358.9±37.0 °C(Predicted)
Density 
1.539±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)
pka
9.47±0.70(Predicted)
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
5mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
10mg
Price
$167
Updated
2024/03/01
Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
25mg
Price
$363
Updated
2024/03/01
Cayman Chemical
Product number
22995
Product name
ICA 069673
Purity
≥98%
Packaging
50mg
Price
$723
Updated
2024/03/01
Tocris
Product number
4305
Product name
ICA069673
Purity
≥99%(HPLC)
Packaging
25
Price
$386
Updated
2021/12/16
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ICA 069673 Chemical Properties,Usage,Production

Description

ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.

storage

Room temperature

ICA 069673 Preparation Products And Raw materials

Raw materials

Preparation Products

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ICA 069673 Suppliers

China 48 India 1 United Kingdom 1 United States 10 Global 60
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
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510
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EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
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United States
ProdList
8447
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60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
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6391
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58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
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19553
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Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
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58
ApexBio Technology
Tel
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Email
sales@apexbt.com
Country
United States
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6251
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Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
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6213
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United States Biological
Tel
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Email
chemicals@usbio.net
Country
United States
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6214
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MedChemExpress
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sales@medchemexpress.com
Country
United States
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582323-16-8, ICA 069673Related Search:


  • ICA 069673
  • N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
  • ICA069673;ICA-069673
  • Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-
  • ICA-069673 >=98% (HPLC)
  • Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
  • N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide
  • 582323-16-8
  • C11H6ClF2N3O
  • Selective KCNQ2/Q3 potassium channel opener.