Pyrido[2,3-d]pyrimidine, 6-bromo-4-chloro-
- Product Name
- Pyrido[2,3-d]pyrimidine, 6-bromo-4-chloro-
- CAS No.
- 1215787-31-7
- Chemical Name
- Pyrido[2,3-d]pyrimidine, 6-bromo-4-chloro-
- Synonyms
- 6-BroMo-4-chloropyrido[2,...;Pyrido[2,3-d]pyrimidine, 6-bromo-4-chloro-
- CBNumber
- CB92552850
- Molecular Formula
- C7H3BrClN3
- Formula Weight
- 244.48
- MOL File
- 1215787-31-7.mol
Pyrido[2,3-d]pyrimidine, 6-bromo-4-chloro- Property
- Melting point:
- 152-154 °C
- Boiling point:
- 334.0±37.0 °C(Predicted)
- Density
- 1.861±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- -1.41±0.30(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B679293
- Product name
- 6-Bromo-4-chloropyrido[2,3-d]pyrimidine
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- NB44335
- Product name
- 6-Bromo-4-chloropyrido[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 3H32-D-87
- Product name
- 6-Bromo-4-chloropyrido[2,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- X9497
- Product name
- 6-Bromo-4-chloropyrido[2,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $237
- Updated
- 2021/12/16
- Product number
- NB44335
- Product name
- 6-Bromo-4-chloropyrido[2,3-d]pyrimidine
- Packaging
- 50mg
- Price
- $95
- Updated
- 2021/12/16
Pyrido[2,3-d]pyrimidine, 6-bromo-4-chloro- Chemical Properties,Usage,Production
Synthesis
155690-79-2
1215787-31-7
General procedure for the synthesis of 6-bromo-4-chloropyrido[2,3-d]pyrimidin-4(1H)-one from 6-bromopyrido[2,3-d]pyrimidin-4(1H)-one: 6-bromopyrido[2,3-d]pyrimidin-4(1H)-one (3.0 g) was mixed with phosphorus trichloride (POCl3, 15 mL) and heated to reflux for 3 hours at 130 °C under nitrogen atmosphere. Upon completion of the reaction, the dark homogeneous solution was concentrated under reduced pressure and diluted with ethyl acetate (EtOAc, 150 mL). The resulting brown non-homogeneous slurry was slowly poured into an ice-water mixture, neutralized to pH neutrality by the addition of sodium bicarbonate (NaHCO3), and the mixture was allowed to gradually warm to room temperature. Subsequently, the organic layer was separated by further diluting the mixture with ethyl acetate (75 mL). The organic layer was washed sequentially with saturated aqueous sodium chloride (NaCl), dried over anhydrous magnesium sulfate (MgSO4) and filtered through a diatomaceous earth pad and silica gel column. The filtrate was concentrated to give a light yellow crude product, which was recrystallized by stirring in a 50% ethyl acetate/hexane solvent mixture. After filtration, 6-bromo-4-chloropyrido[2,3-d]pyrimidine was obtained as a light yellow crystalline solid (1.8 g, purity: 95%).
References
[1] Patent: WO2015/157093, 2015, A1. Location in patent: Paragraph 1314; 1316
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1713 - 1726
Pyrido[2,3-d]pyrimidine, 6-bromo-4-chloro- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pyrido[2,3-d]pyrimidine, 6-bromo-4-chloro- manufacturers
- Product
- 6-bromo-4-chloropyrido[2,3-d]pyrimidine 1215787-31-7
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02