(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile
- Product Name
- (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile
- CAS No.
- 848344-36-5
- Chemical Name
- (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile
- Synonyms
- CS-401;AS 602801;Bentamapimod;AS 602801 (BentaMapiMod);Bentamapimod (AS 602801);AS-602801;BENTAMAPIMOD;AS602801;AS-602801,inhibit,JNK,Inhibitor,Bentamapimod,AS602801;2-Benzothiazoleacetonitrile, α-[2-[[4-(4-morpholinylmethyl)phenyl]methoxy]-4-pyrimidinyl]-;2-(Benzo[d]thiazol-2-yl)-2-(2-((4-(morpholinomethyl)benzyl)oxy)pyrimidin-4-yl)acetonitrile;(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile
- CBNumber
- CB92589641
- Molecular Formula
- C25H23N5O2S
- Formula Weight
- 457.55
- MOL File
- 848344-36-5.mol
(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Property
- Boiling point:
- 666.5±65.0 °C(Predicted)
- Density
- 1.326
- storage temp.
- 2-8°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥11.45 mg/mL in DMSO
- form
- solid
- pka
- 6.47±0.10(Predicted)
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML3358
- Product name
- AS602801
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $81.2
- Updated
- 2024/03/01
- Product number
- SML3358
- Product name
- AS602801
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $327
- Updated
- 2024/03/01
- Product number
- 21482
- Product name
- Bentamapimod
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 21482
- Product name
- Bentamapimod
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $177
- Updated
- 2024/03/01
- Product number
- 21482
- Product name
- Bentamapimod
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $254
- Updated
- 2024/03/01
(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Chemical Properties,Usage,Production
Description
Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively. It is selective for JNKs over a panel of 25 related kinases. Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis. It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.
Uses
Bentamapimod is a potent and selective JNK inhibitor with therapeutic potential in MS (multiple sclerosis) and fibrosis. Studies show that Bentamapimod also reduced induced endometriosis in baboons.
in vitro
as602801 blocked t-lymphocyte proliferation and induced apoptosis. in rrms cd4t and cd8t cells, as602801 induced apoptosis genes and expression of surface markers, while in rrms cd11bt cells it induced expression of innate immunity receptors and co-stimulatory molecules [1].
in vivo
as602801, the best jnk inhibitors identified so far, were currently evaluated in preclinical studies, based on preliminary promising results in animal model of auto-immune diseases and neuronal apoptosis [1].
References
[1] ferrandi c, richard f, tavano p, hauben e, barbié v, gotteland jp, greco b, fortunato m, mariani mf, furlan r, comi g, martino g, zaratin pf. characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-jun n-terminal kinase pathway biomarkers. mult scler. 2011;17(1):43-56.
(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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