YS121

Product Name: YS121
CAS No.: 916482-17-2
Chemical Name: YS121
Synonyms: YS121;YS121 Exclusive;HVJBWTVMRIOTEL-UHFFFAOYSA-N;Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
CBNumber: CB92592892
Molecular Formula: C20H26ClN3O2S
Formula Weight: 407.96
MOL File: 916482-17-2.mol

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YS121 Property

Boiling point:: 557.4±50.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka: 3.04±0.21(Predicted)
form: solution in acetate.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13665
Product name: YS-121
Purity: ≥98%
Packaging: 1mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 13665
Product name: YS-121
Purity: ≥98%
Packaging: 5mg
Price: $236
Updated: 2024/03/01

Cayman Chemical

Product number: 13665
Product name: YS-121
Purity: ≥98%
Packaging: 10mg
Price: $420
Updated: 2024/03/01

Cayman Chemical

Product number: 13665
Product name: YS-121
Purity: ≥98%
Packaging: 25mg
Price: $914
Updated: 2024/03/01

AK Scientific

Product number: 1614DC
Product name: 2-[4-Chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoicacid
Packaging: 10mg
Price: $564
Updated: 2021/12/16

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YS121 Chemical Properties,Usage,Production

Description

Microsomal prostaglandin E₂ synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE₂, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of mPGES-1 (IC₅₀ = 3.9 μM) and 5-LO (IC₅₀ = 4.1 μM). It effectively inhibits PGE₂ and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE₂ and LTB₄ while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy. YS-121 has minor effects on COX-1 and COX-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.

Definition

ChEBI: Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]- is a medium-chain fatty acid.

References

[1] koeberle a, zettl h, greiner c, et al. pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin e2 synthase-1 and 5-lipoxygenase[j]. journal of medicinal chemistry, 2008, 51(24): 8068-8076.
[2] mehrotra s, morimiya a, agarwal b, et al. microsomal prostaglandin e2 synthase‐1 in breast cancer: a potential target for therapy[j]. the journal of pathology, 2006, 208(3): 356-363.werz o, greiner c, koeberle a, et al. novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid[j]. journal of medicinal chemistry, 2008, 51(17): 5449-5453.koeberle a, rossi a, zettl h, et al. the molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2, 3-dimethylphenylamino) pyrimidin-2-ylthio) octanoic acid (ys121), a dual inhibitor of microsomal prostaglandin e2 synthase-1 and 5-lipoxygenase[j]. journal of pharmacology and experimental therapeutics, 2010, 332(3): 840-848.

YS121 Preparation Products And Raw materials

Raw materials

Preparation Products

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YS121 Suppliers

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YS121 Exclusive

Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-

916482-17-2