2-Bromo-7-iodofluorene

Product Name: 2-Bromo-7-iodofluorene
CAS No.: 123348-27-6
Chemical Name: 2-Bromo-7-iodofluorene
Synonyms: 2-BROMO-7-IODO-9H-FL;2-BroMo-7-iodofluorene;2-bromo-7-iodo-fluoren;2-Bromo-7-iodo-9H-fluoren;2-broMine-7-iodinefluorene;2-BroMo-7-iodo-9H-fluorene;2-Bromo-7-iodofluorene >9H-Fluorene, 2-broMo-7-iodo-;Phenol,6-(bromomethyl)-,acetate;2-Bromo-7-iodo-9H-fluoren123348-27-6
CBNumber: CB92594391
Molecular Formula: C13H8BrI
Formula Weight: 371.01
MOL File: 123348-27-6.mol

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2-Bromo-7-iodofluorene Property

Melting point:: 178-180℃
Boiling point:: 426.5±38.0 °C(Predicted)
Density: 1.988±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Toluene
form: powder to crystal
color: White to Orange to Green
InChI: InChI=1S/C13H8BrI/c14-10-1-3-12-8(6-10)5-9-7-11(15)2-4-13(9)12/h1-4,6-7H,5H2
InChIKey: GWUPMAMGLLLLHO-UHFFFAOYSA-N
SMILES: C1C2=C(C=CC(I)=C2)C2=C1C=C(Br)C=C2

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Safety

HS Code: 2902900000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4431
Product name: 2-Bromo-7-iodofluorene
Purity: >98.0%(GC)
Packaging: 5g
Price: $56
Updated: 2025/07/31

TCI Chemical

Product number: B4431
Product name: 2-Bromo-7-iodofluorene
Purity: >98.0%(GC)
Packaging: 25g
Price: $168
Updated: 2025/07/31

TRC

Product number: B686878
Product name: 2-Bromo-7-iodo-9H-fluorene
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: AMTH232
Product name: 2-Bromo-7-iodo-9H-fluorene
Packaging: 5g
Price: $15
Updated: 2021/12/16

Ambeed

Product number: A329512
Product name: 2-Bromo-7-iodo-9H-fluorene
Purity: 98%
Packaging: 10g
Price: $17
Updated: 2021/12/16

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2-Bromo-7-iodofluorene Chemical Properties,Usage,Production

Uses

2-Bromo-7-iodofluorene is mainly used as intermediate of Ledipasvir. Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion.

Synthesis

1133-80-8

123348-27-6

Example 7 Synthesis of 2-bromo-7-iodofluorene: 2-bromofluorene (12.61 g, 50 mmol), acetic acid (125 mL), water (9 mL), concentrated sulfuric acid (4 mL), iodine (5.1 g, 20.1 mmol), and iodic acid (2.2 g, 12.5 mmol) were mixed and heated to react for 2 hr at 80-90 °C. After completion of the reaction, the mixture was cooled and filtered. The resulting solid was washed sequentially with acetic acid (100 mL) and water (500 mL) to afford the target product 2-bromo-7-iodofluorene 14.7 g in 79% yield and melting point 179-185 °C. The product was analyzed by mass spectrometry. The results of mass spectrometry analysis (m/z): 418 (M + diiodo), 370, 372 (M + iodobromo), 322, 324, 326 (M + dibromo).

References

[1] Journal of Fluorine Chemistry, 2015, vol. 178, p. 195 - 201
[2] Patent: US2013/324740, 2013, A1. Location in patent: Paragraph 0203; 0204
[3] Patent: US2013/324496, 2013, A1. Location in patent: Paragraph 0239-0240
[4] Chemical Communications, 2002, # 15, p. 1608 - 1609
[5] Patent: WO2011/105700, 2011, A1. Location in patent: Page/Page column 19; 20

2-Bromo-7-iodofluorene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-7-iodofluorene Suppliers

Americas 1 China 181 Europe 1 Germany 1 India 3 Japan 1 The Netherlands 1 Ukraine 1 United States 12 Global 202

Zhengzhou Changkuan Technology Co., Ltd

Tel: 0371-63769919 18530983798
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Tel: 0393-0393-0393-8910800 15039333257
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Shanghai Hanhong Scientific Co.,Ltd.

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ZhengZhou HuaWen Chemical Co.Ltd

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View Lastest Price from 2-Bromo-7-iodofluorene manufacturers

Shanghai Daken Advanced Materials Co.,Ltd

Product: 2-Bromo-7-iodo-9H-fluoren 123348-27-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG /month
Release date: 2021-11-17

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Bromo-7-Iodo-9h-Fluorene 123348-27-6
Price: US $10.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10 ton
Release date: 2024-08-20

Henan Fengda Chemical Co., Ltd

Product: 2-Bromo-7-iodofluorene 123348-27-6
Price: US $31.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-25

123348-27-6, 2-Bromo-7-iodofluoreneRelated Search:

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123348-27-6