ChemicalBook > CAS DataBase List > 2-Bromo-7-iodofluorene

2-Bromo-7-iodofluorene

Product Name
2-Bromo-7-iodofluorene
CAS No.
123348-27-6
Chemical Name
2-Bromo-7-iodofluorene
Synonyms
2-BROMO-7-IODO-9H-FL;2-BroMo-7-iodofluorene;2-bromo-7-iodo-fluoren;2-Bromo-7-iodo-9H-fluoren;2-broMine-7-iodinefluorene;2-BroMo-7-iodo-9H-fluorene;2-Bromo-7-iodofluorene >9H-Fluorene, 2-broMo-7-iodo-;Phenol,6-(bromomethyl)-,acetate;2-Bromo-7-iodo-9H-fluoren123348-27-6
CBNumber
CB92594391
Molecular Formula
C13H8BrI
Formula Weight
371.01
MOL File
123348-27-6.mol
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2-Bromo-7-iodofluorene Property

Melting point:
178-180℃
Boiling point:
426.5±38.0 °C(Predicted)
Density 
1.988±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Toluene
form 
powder to crystal
color 
White to Orange to Green
InChI
InChI=1S/C13H8BrI/c14-10-1-3-12-8(6-10)5-9-7-11(15)2-4-13(9)12/h1-4,6-7H,5H2
InChIKey
GWUPMAMGLLLLHO-UHFFFAOYSA-N
SMILES
C1C2=C(C=CC(I)=C2)C2=C1C=C(Br)C=C2
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Safety

HS Code 
2902900000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4431
Product name
2-Bromo-7-iodofluorene
Purity
>98.0%(GC)
Packaging
5g
Price
$56
Updated
2025/07/31
TCI Chemical
Product number
B4431
Product name
2-Bromo-7-iodofluorene
Purity
>98.0%(GC)
Packaging
25g
Price
$168
Updated
2025/07/31
TRC
Product number
B686878
Product name
2-Bromo-7-iodo-9H-fluorene
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
AMTH232
Product name
2-Bromo-7-iodo-9H-fluorene
Packaging
5g
Price
$15
Updated
2021/12/16
Ambeed
Product number
A329512
Product name
2-Bromo-7-iodo-9H-fluorene
Purity
98%
Packaging
5g
Price
$11
Updated
2021/12/16
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2-Bromo-7-iodofluorene Chemical Properties,Usage,Production

Uses

2-Bromo-7-iodofluorene is mainly used as intermediate of Ledipasvir. Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion.

Synthesis

1133-80-8

123348-27-6

Example 7 Synthesis of 2-bromo-7-iodofluorene: 2-bromofluorene (12.61 g, 50 mmol), acetic acid (125 mL), water (9 mL), concentrated sulfuric acid (4 mL), iodine (5.1 g, 20.1 mmol), and iodic acid (2.2 g, 12.5 mmol) were mixed and heated to react for 2 hr at 80-90 °C. After completion of the reaction, the mixture was cooled and filtered. The resulting solid was washed sequentially with acetic acid (100 mL) and water (500 mL) to afford the target product 2-bromo-7-iodofluorene 14.7 g in 79% yield and melting point 179-185 °C. The product was analyzed by mass spectrometry. The results of mass spectrometry analysis (m/z): 418 (M + diiodo), 370, 372 (M + iodobromo), 322, 324, 326 (M + dibromo).

References

[1] Journal of Fluorine Chemistry, 2015, vol. 178, p. 195 - 201
[2] Patent: US2013/324740, 2013, A1. Location in patent: Paragraph 0203; 0204
[3] Patent: US2013/324496, 2013, A1. Location in patent: Paragraph 0239-0240
[4] Chemical Communications, 2002, # 15, p. 1608 - 1609
[5] Patent: WO2011/105700, 2011, A1. Location in patent: Page/Page column 19; 20

2-Bromo-7-iodofluorene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-7-iodofluorene Suppliers

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View Lastest Price from 2-Bromo-7-iodofluorene manufacturers

Shanghai Daken Advanced Materials Co.,Ltd
Product
2-Bromo-7-iodo-9H-fluoren 123348-27-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG /month
Release date
2021-11-17
Hebei Chuanghai Biotechnology Co,.LTD
Product
2-Bromo-7-Iodo-9h-Fluorene 123348-27-6
Price
US $10.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10 ton
Release date
2024-08-20
Henan Fengda Chemical Co., Ltd
Product
2-Bromo-7-iodofluorene 123348-27-6
Price
US $31.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-25

123348-27-6, 2-Bromo-7-iodofluoreneRelated Search:

2-bromo-7-iodofluoren-9-one 7-Bromo-2-iodo-9,9-dimethyl-9H-fluorene Thionyl chloride 4,4'-DIBROMO-4''-PHENYLTRIPHENYLAMINE

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