5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester
- Product Name
- 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester
- CAS No.
- 172678-67-0
- Chemical Name
- 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester
- Synonyms
- ethyl 2-phenylthiazole-5-carboxylate;5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester
- CBNumber
- CB92594492
- Molecular Formula
- C12H11NO2S
- Formula Weight
- 233.29
- MOL File
- 172678-67-0.mol
5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester Property
- Melting point:
- 64.8-65.8 °C
- Boiling point:
- 365.2±34.0 °C(Predicted)
- Density
- 1.216±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.61±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y5301
- Product name
- Ethyl2-phenylthiazole-5-carboxylate
- Packaging
- 100mg
- Price
- $212
- Updated
- 2021/12/16
- Product number
- Y5301
- Product name
- Ethyl2-phenylthiazole-5-carboxylate
- Packaging
- 250mg
- Price
- $309
- Updated
- 2021/12/16
- Product number
- Y5301
- Product name
- Ethyl2-phenylthiazole-5-carboxylate
- Packaging
- 1g
- Price
- $698
- Updated
- 2021/12/16
- Product number
- 180907
- Product name
- 2-Phenylthiazole-5-carboxylic acid ethyl ester
- Purity
- 95%+
- Packaging
- 1g
- Price
- $728
- Updated
- 2021/12/16
- Product number
- Y5301
- Product name
- Ethyl2-phenylthiazole-5-carboxylate
- Packaging
- 5g
- Price
- $1994
- Updated
- 2021/12/16
5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester Chemical Properties,Usage,Production
Synthesis
33142-21-1
2227-79-4
172678-67-0
To a solution of ethyl 2-chloro-3-oxopropionate (4.5 g, 30.0 mmol) and thiobenzamide (4.1 g, 30.0 mmol) in toluene (50 mL) was added magnesium sulfate heptahydrate (7.2 g, 59.8 mmol). The reaction mixture was stirred at 100 °C for 4 h. Upon completion of the reaction, the reaction was quenched with ice water (100 mL). Subsequently, the reaction mixture was extracted with ether (3 x 50 mL), the organic phases were combined, washed with saturated brine (50 mL) and dried over anhydrous sodium sulfate. The drier was removed by filtration and the filtrate was concentrated under reduced pressure to give the crude product ethyl 2-phenylthiazole-5-carboxylate. The crude product was purified by silica gel column chromatography, using petroleum ether/ethyl acetate (10:1) as eluent, the target fraction was collected, and the pure ethyl 2-phenylthiazole-5-carboxylate was obtained after concentration under reduced pressure (3.2 g, 45.9% yield). Mass spectrum (ESI) m/z: 234.1 [M+H]+.
References
[1] Patent: US2018/271846, 2018, A1. Location in patent: Paragraph 0121; 0124; 0125
[2] Patent: WO2018/160878, 2018, A1. Location in patent: Page/Page column 287-288
[3] Journal of Chemical Research, 2011, vol. 35, # 5, p. 313 - 316
5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester manufacturers
- Product
- 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester 172678-67-0
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 5kg; 10kg
- Release date
- 2020-10-27