5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester
- Product Name
- 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester
- CAS No.
- 172678-67-0
- Chemical Name
- 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester
- Synonyms
- ethyl 2-phenylthiazole-5-carboxylate;5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester
- CBNumber
- CB92594492
- Molecular Formula
- C12H11NO2S
- Formula Weight
- 233.29
- MOL File
- 172678-67-0.mol
5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester Property
- Melting point:
- 64.8-65.8 °C
- Boiling point:
- 365.2±34.0 °C(Predicted)
- Density
- 1.216±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.61±0.10(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- Y5301
- Product name
- Ethyl2-phenylthiazole-5-carboxylate
- Packaging
- 100mg
- Price
- $212
- Updated
- 2021/12/16
- Product number
- Y5301
- Product name
- Ethyl2-phenylthiazole-5-carboxylate
- Packaging
- 250mg
- Price
- $309
- Updated
- 2021/12/16
- Product number
- Y5301
- Product name
- Ethyl2-phenylthiazole-5-carboxylate
- Packaging
- 1g
- Price
- $698
- Updated
- 2021/12/16
- Product number
- 180907
- Product name
- 2-Phenylthiazole-5-carboxylic acid ethyl ester
- Purity
- 95%+
- Packaging
- 1g
- Price
- $728
- Updated
- 2021/12/16
- Product number
- Y5301
- Product name
- Ethyl2-phenylthiazole-5-carboxylate
- Packaging
- 5g
- Price
- $1994
- Updated
- 2021/12/16
5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester Chemical Properties,Usage,Production
Synthesis
33142-21-1
2227-79-4
172678-67-0
To a solution of ethyl 2-chloro-3-oxopropionate (4.5 g, 30.0 mmol) and thiobenzamide (4.1 g, 30.0 mmol) in toluene (50 mL) was added magnesium sulfate heptahydrate (7.2 g, 59.8 mmol). The reaction mixture was stirred at 100 °C for 4 h. Upon completion of the reaction, the reaction was quenched with ice water (100 mL). Subsequently, the reaction mixture was extracted with ether (3 x 50 mL), the organic phases were combined, washed with saturated brine (50 mL) and dried over anhydrous sodium sulfate. The drier was removed by filtration and the filtrate was concentrated under reduced pressure to give the crude product ethyl 2-phenylthiazole-5-carboxylate. The crude product was purified by silica gel column chromatography, using petroleum ether/ethyl acetate (10:1) as eluent, the target fraction was collected, and the pure ethyl 2-phenylthiazole-5-carboxylate was obtained after concentration under reduced pressure (3.2 g, 45.9% yield). Mass spectrum (ESI) m/z: 234.1 [M+H]+.
References
[1] Patent: US2018/271846, 2018, A1. Location in patent: Paragraph 0121; 0124; 0125
[2] Patent: WO2018/160878, 2018, A1. Location in patent: Page/Page column 287-288
[3] Journal of Chemical Research, 2011, vol. 35, # 5, p. 313 - 316
5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester Suppliers
- Tel
- 10-61256048 13810278579
- Fax
- +86 10 61256049
- sales@zeroschem.com
- Country
- China
- ProdList
- 1370
- Advantage
- 59
- Tel
- 027-86697669 13986148687
- Fax
- 86-027-86697669
- sales@tcaschem.com
- Country
- China
- ProdList
- 3993
- Advantage
- 55
- Tel
- 0513-0513-51005092 13390947892
- Fax
- 0513-51005092
- tashiyxy@163.com
- Country
- China
- ProdList
- 839
- Advantage
- 58
- Tel
- 021-31007982 18019432809
- Fax
- 021-31007982
- info@xrpharma.com
- Country
- China
- ProdList
- 676
- Advantage
- 55
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- +86-2332782371 +86-18120098618
- sales@adobechem.com
- Country
- China
- ProdList
- 1250
- Advantage
- 50
- Tel
- 515-88280676 18921872653
- sales@ximanbio.com
- Country
- China
- ProdList
- 1524
- Advantage
- 56
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 18621295758
- Fax
- -QQ:1449085402
- 1449085402@qq.com
- Country
- China
- ProdList
- 1824
- Advantage
- 55
- Tel
- 2332782371
- Fax
- QQ: 2332782371
- adobechem@qq.com
- Country
- China
- ProdList
- 7980
- Advantage
- 58
View Lastest Price from 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester manufacturers
- Product
- 5-Thiazolecarboxylic acid, 2-phenyl-, ethyl ester 172678-67-0
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 5kg; 10kg
- Release date
- 2020-10-27