ChemicalBook > CAS DataBase List > 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE

Product Name
4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE
CAS No.
151103-09-2
Chemical Name
4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE
Synonyms
Roflumilast intermediate A;3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde;Roflumilast Impurity 32;RofluMilast interMediate;RofluMilast InterMediate I;Intermediate Of Roflumilast;Benzaldehyde, 3-(cyclopropylMethoxy)-4;ROFLUMILAST INTERMEDIATE CAS 151103-09-2;4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOX...;3-CyclopropylMethoxy-4-isopropoxy-benzaldehyde
CBNumber
CB9259483
Molecular Formula
C12H12F2O3
Formula Weight
242.22
MOL File
151103-09-2.mol
More
Less

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE Property

Boiling point:
331.3±37.0 °C(Predicted)
Density 
1.277±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C12H12F2O3/c13-12(14)17-10-4-3-9(6-15)5-11(10)16-7-8-1-2-8/h3-6,8,12H,1-2,7H2
InChIKey
AHVVCELVGCPYGI-UHFFFAOYSA-N
SMILES
C(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
C997803
Product name
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
C997803
Product name
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
X3187
Product name
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
Packaging
1g
Price
$146
Updated
2021/12/16
Matrix Scientific
Product number
081566
Product name
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
Purity
97%
Packaging
1g
Price
$375
Updated
2021/12/16
AK Scientific
Product number
X3187
Product name
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
Packaging
10g
Price
$492
Updated
2021/12/16
More
Less

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

7051-34-5

151103-08-1

151103-09-2

The general procedure for the synthesis of 4-(difluoromethoxy)-3-(cyclopropylmethoxy)benzaldehyde from bromomethylcyclopropane and 4-difluoromethoxy-3-hydroxybenzaldehyde was as follows: 55 g of 4-(difluoromethoxy)-3-hydroxybenzaldehyde, 42.42 g of K2CO3 (1.05 eq.), 4.86 g of KI (0.1 eq.), and 220 mL of dimethyl sulfoxide ( DMSO) were added to the reactor. The mixture was heated and stirred at 70 °C for 1 hour. Subsequently, a pre-prepared mixture of 42.65 g of bromomethylcyclopropane (1.08 eq.) and 110 mL of DMSO was slowly added dropwise for a controlled time of 1 hour. After the dropwise addition was completed, the reaction was continued at 70 °C for 3 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature. The reaction mixture was diluted by adding 375 mL of toluene and filtered to remove unreacted K2CO3. The filtrate was cooled to 0-5 °C and 375 mL of deionized water was added. The organic and aqueous phases were separated and the organic phase was washed twice with 55 mL of deionized water. Finally, the solvent was removed by distillation under reduced pressure to give 70 g (99% yield) of 4-(difluoromethoxy)-3-(cyclopropylmethoxy)benzaldehyde as a viscous pale yellow liquid.

References

[1] Patent: WO2014/60464, 2014, A1. Location in patent: Page/Page column 15
[2] Patent: CN105254559, 2016, A. Location in patent: Paragraph 0041; 0042
[3] Patent: US2008/15226, 2008, A1. Location in patent: Page/Page column 10
[4] Patent: US2006/116373, 2006, A1. Location in patent: Page/Page column 6
[5] Organic and Biomolecular Chemistry, 2018, vol. 16, # 38, p. 6900 - 6908

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE Suppliers

China 184 China Hong Kong 1 India 5 United States 11 Global 201
Parth Antibiotics Pvt Ltd.
Tel
--
Fax
--
Country
India
ProdList
173
Advantage
50
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE manufacturers

Honest Joy Holdings Limited
Product
Benzaldehyde 151103-09-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98.9%
Supply Ability
100 tons
Release date
2022-02-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE 151103-09-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE 151103-09-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

151103-09-2, 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDERelated Search:

N-(3-Chloropyridin-4-yl)-3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzaMide RofluMilast related substance N-(3,5-Dichloro-4-pyridinyl)-3,4-bis(difluoroMethoxy)benzaMide Roflumilast Impurity 14 RofluMilast N-Oxide Roflumilast RofluMilast related substance 4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast 4-Amino-3,5-dichloropyridine (-)-PERILLALDEHYDE 3-(cyclopropylMethoxy)-N-(3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzoyl)-N-(3,5-dichloropyridin-4-yl)-4-(difluoroMethoxy)benzaMide BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- 3-CyclopropylMethoxy-4-Hydroxybenzaldehyde 3,4-BIS-DIFLUOROMETHOXY-BENZALDEHYDE 3,4-DifluoroMethoxybenzaldehyde 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Roflumilast

  • Roflumilast intermediate A
  • 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyd
  • 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
  • RofluMilast interMediate
  • Benzaldehyde, 3-(cyclopropylMethoxy)-4-(difluoroMethoxy)-
  • 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE
  • 3-CyclopropylMethoxy-4-isopropoxy-benzaldehyde
  • RofluMilast InterMediate I
  • 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOX...
  • Intermediate Of Roflumilast
  • Benzaldehyde, 3-(cyclopropylMethoxy)-4
  • ROFLUMILAST INTERMEDIATE CAS 151103-09-2
  • 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALD
  • 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde, 97+%
  • 4-(difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldethyde
  • 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE, 3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde, Roflumilast intermediate A, 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde, RofluMilast interMediate, RofluMilast InterMediate I, Intermediate Of Roflumilast, Benzaldehyde, 3-(cyclopropylMethoxy)-4, ROFLUMILAST INTERMEDIATE CAS 151103-09-2, 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOX..., 3-CyclopropylMethoxy-4-isopropoxy-benzaldehyde, 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZAL
  • Roflumilast Impurity 32
  • 151103-09-2
  • C12H12F2O3
  • Roflumilast interemdiate
  • Fluorine series