3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

Product Name: 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
CAS No.: 162401-62-9
Chemical Name: 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
Synonyms: RofluM;Roflumilast Impurity J;Roflumilast Acid Impurity;Roflumilast intermediate B;RofluMilast InterMediate II;Acid Impurity of Roflumilast;Roflumilast Related Compound D;Roflumilast USP Related Compound D;Roflumilast Carboxylic Acid Impurity;CYCLOPROPYL DIFLUOROMETHOXYBENOZOIC ACID
CBNumber: CB02487690
Molecular Formula: C12H12F2O4
Formula Weight: 258.22
MOL File: 162401-62-9.mol

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3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Property

Melting point:: 118-120℃
Boiling point:: 356.4±37.0 °C(Predicted)
Density: 1.355±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.87±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C12H12F2O4/c13-12(14)18-9-4-3-8(11(15)16)5-10(9)17-6-7-1-2-7/h3-5,7,12H,1-2,6H2,(H,15,16)
InChIKey: IGFDIFLMMLWKKY-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference: 162401-62-9

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: 2811
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000161
Product name: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
Packaging: 1g
Price: $104
Updated: 2024/03/01

Alfa Aesar

Product number: H64098
Product name: 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98%
Packaging: 1g
Price: $62.9
Updated: 2024/03/01

Alfa Aesar

Product number: H64098
Product name: 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98%
Packaging: 5g
Price: $241
Updated: 2024/03/01

Alfa Aesar

Product number: H64098
Product name: 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98%
Packaging: 250mg
Price: $20.9
Updated: 2023/06/20

TRC

Product number: C988720
Product name: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
Packaging: 1g
Price: $70
Updated: 2021/12/16

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3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Chemical Properties,Usage,Production

Uses

An impurity and intermediate in the preparation of selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Suppliers

Canada 1 China 249 Europe 1 India 8 Japan 1 United Kingdom 2 United States 13 Global 275

Hefei TianRui Pharmaceutical Chemistry Co., Ltd.

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View Lastest Price from 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid manufacturers

Wuhan Quanjinci New Material Co.,Ltd.

Product: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid 162401-62-9
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000000 tons
Release date: 2023-11-07

Honest Joy Holdings Limited

Product: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid 162401-62-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.1%
Supply Ability: 100 tons
Release date: 2022-02-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 162401-62-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

162401-62-9, 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acidRelated Search:

Roflumilast benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- 3-(cyclopropylMethoxy)-N-(3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzoyl)-N-(3,5-dichloropyridin-4-yl)-4-(difluoroMethoxy)benzaMide Roflumilast-d4 4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast 4-Amino-3,5-dichloropyridine RofluMilast N-Oxide RofluMilast related substance Roflumilast N-(3-Chloropyridin-4-yl)-3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzaMide 4-Amino-3,5-dichloropyridine N-oxide RofluMilast related substance 3,5-DICHLORO-4-AMINOPYRIDINE Roflumilast N-oxide D4 3-CyclopropylMethoxy-4-Hydroxybenzaldehyde 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE 3,4-BIS-DIFLUOROMETHOXY-BENZALDEHYDE

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

3-CyclopropyMethoxy-4-difluoroMethoxy benzoic acid

Benzoic acid, 3-(cyclopropylMethoxy)-4-(difluoroMethoxy)-

CYCLOPROPYL DIFLUOROMETHOXYBENOZOIC ACID

3-CyclopropylMethoxy-4-isopropoxy-benzoic acid

RofluMilast InterMediate II

Roflumilast intermediate (3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid)

Roflumilast Acid Impurity

3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, >=98%

Roflumilast intermediate B

Roflumilast Impurity J

RofluM

Roflumilast Carboxylic Acid Impurity

Roflumilast Related Compound D

Roflumilast USP Related Compound D

Acid Impurity of Roflumilast

162401-62-9

C12H12O4F2

Roflumilast interemdiate

Intermediates