4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE

Product Name: 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE
CAS No.: 151103-09-2
Chemical Name: 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE
Synonyms: Roflumilast intermediate A;3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde;Roflumilast Impurity 32;RofluMilast interMediate;RofluMilast InterMediate I;Intermediate Of Roflumilast;Benzaldehyde, 3-(cyclopropylMethoxy)-4;ROFLUMILAST INTERMEDIATE CAS 151103-09-2;4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOX...;3-CyclopropylMethoxy-4-isopropoxy-benzaldehyde
CBNumber: CB9259483
Molecular Formula: C12H12F2O3
Formula Weight: 242.22
MOL File: 151103-09-2.mol

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4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE Property

Boiling point:: 331.3±37.0 °C(Predicted)
Density: 1.277±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C12H12F2O3/c13-12(14)17-10-4-3-9(6-15)5-11(10)16-7-8-1-2-8/h3-6,8,12H,1-2,7H2
InChIKey: AHVVCELVGCPYGI-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C997803
Product name: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C997803
Product name: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: X3187
Product name: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
Packaging: 1g
Price: $146
Updated: 2021/12/16

Matrix Scientific

Product number: 081566
Product name: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
Purity: 97%
Packaging: 1g
Price: $375
Updated: 2021/12/16

AK Scientific

Product number: X3187
Product name: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
Packaging: 10g
Price: $492
Updated: 2021/12/16

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4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

7051-34-5

151103-08-1

151103-09-2

The general procedure for the synthesis of 4-(difluoromethoxy)-3-(cyclopropylmethoxy)benzaldehyde from bromomethylcyclopropane and 4-difluoromethoxy-3-hydroxybenzaldehyde was as follows: 55 g of 4-(difluoromethoxy)-3-hydroxybenzaldehyde, 42.42 g of K2CO3 (1.05 eq.), 4.86 g of KI (0.1 eq.), and 220 mL of dimethyl sulfoxide ( DMSO) were added to the reactor. The mixture was heated and stirred at 70 °C for 1 hour. Subsequently, a pre-prepared mixture of 42.65 g of bromomethylcyclopropane (1.08 eq.) and 110 mL of DMSO was slowly added dropwise for a controlled time of 1 hour. After the dropwise addition was completed, the reaction was continued at 70 °C for 3 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature. The reaction mixture was diluted by adding 375 mL of toluene and filtered to remove unreacted K2CO3. The filtrate was cooled to 0-5 °C and 375 mL of deionized water was added. The organic and aqueous phases were separated and the organic phase was washed twice with 55 mL of deionized water. Finally, the solvent was removed by distillation under reduced pressure to give 70 g (99% yield) of 4-(difluoromethoxy)-3-(cyclopropylmethoxy)benzaldehyde as a viscous pale yellow liquid.

References

[1] Patent: WO2014/60464, 2014, A1. Location in patent: Page/Page column 15
[2] Patent: CN105254559, 2016, A. Location in patent: Paragraph 0041; 0042
[3] Patent: US2008/15226, 2008, A1. Location in patent: Page/Page column 10
[4] Patent: US2006/116373, 2006, A1. Location in patent: Page/Page column 6
[5] Organic and Biomolecular Chemistry, 2018, vol. 16, # 38, p. 6900 - 6908

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE Suppliers

China 184 China Hong Kong 1 India 5 United States 11 Global 201

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View Lastest Price from 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE manufacturers

Honest Joy Holdings Limited

Product: Benzaldehyde 151103-09-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.9%
Supply Ability: 100 tons
Release date: 2022-02-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE 151103-09-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE 151103-09-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

151103-09-2, 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDERelated Search:

N-(3-Chloropyridin-4-yl)-3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzaMide RofluMilast related substance N-(3,5-Dichloro-4-pyridinyl)-3,4-bis(difluoroMethoxy)benzaMide Roflumilast Impurity 14 RofluMilast N-Oxide Roflumilast RofluMilast related substance 4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast 4-Amino-3,5-dichloropyridine (-)-PERILLALDEHYDE 3-(cyclopropylMethoxy)-N-(3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzoyl)-N-(3,5-dichloropyridin-4-yl)-4-(difluoroMethoxy)benzaMide BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- 3-CyclopropylMethoxy-4-Hydroxybenzaldehyde 3,4-BIS-DIFLUOROMETHOXY-BENZALDEHYDE 3,4-DifluoroMethoxybenzaldehyde 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Roflumilast

Roflumilast intermediate A

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyd

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde

RofluMilast interMediate

Benzaldehyde, 3-(cyclopropylMethoxy)-4-(difluoroMethoxy)-

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE

3-CyclopropylMethoxy-4-isopropoxy-benzaldehyde

RofluMilast InterMediate I

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOX...

Intermediate Of Roflumilast

Benzaldehyde, 3-(cyclopropylMethoxy)-4

ROFLUMILAST INTERMEDIATE CAS 151103-09-2

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALD

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde, 97+%

4-(difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldethyde

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE, 3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde, Roflumilast intermediate A, 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde, RofluMilast interMediate, RofluMilast InterMediate I, Intermediate Of Roflumilast, Benzaldehyde, 3-(cyclopropylMethoxy)-4, ROFLUMILAST INTERMEDIATE CAS 151103-09-2, 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOX..., 3-CyclopropylMethoxy-4-isopropoxy-benzaldehyde, 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZAL

Roflumilast Impurity 32

151103-09-2

C12H12F2O3

Roflumilast interemdiate

Fluorine series