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3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

Product Name
3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
CAS No.
162401-62-9
Chemical Name
3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
Synonyms
RofluM;Roflumilast Impurity J;Roflumilast Acid Impurity;Roflumilast intermediate B;RofluMilast InterMediate II;Acid Impurity of Roflumilast;Roflumilast Related Compound D;Roflumilast USP Related Compound D;Roflumilast Carboxylic Acid Impurity;CYCLOPROPYL DIFLUOROMETHOXYBENOZOIC ACID
CBNumber
CB02487690
Molecular Formula
C12H12F2O4
Formula Weight
258.22
MOL File
162401-62-9.mol
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3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Property

Melting point:
118-120℃
Boiling point:
356.4±37.0 °C(Predicted)
Density 
1.355±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.87±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C12H12F2O4/c13-12(14)18-9-4-3-8(11(15)16)5-10(9)17-6-7-1-2-7/h3-5,7,12H,1-2,6H2,(H,15,16)
InChIKey
IGFDIFLMMLWKKY-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference
162401-62-9
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
2811
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
MNO000161
Product name
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
Packaging
1g
Price
$104
Updated
2024/03/01
Alfa Aesar
Product number
H64098
Product name
3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98%
Packaging
1g
Price
$62.9
Updated
2024/03/01
Alfa Aesar
Product number
H64098
Product name
3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98%
Packaging
5g
Price
$241
Updated
2024/03/01
Alfa Aesar
Product number
H64098
Product name
3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98%
Packaging
250mg
Price
$20.9
Updated
2023/06/20
TRC
Product number
C988720
Product name
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
Packaging
1g
Price
$70
Updated
2021/12/16
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3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Chemical Properties,Usage,Production

Uses

An impurity and intermediate in the preparation of selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Suppliers

Canada 1 China 249 Europe 1 India 8 Japan 1 United Kingdom 2 United States 13 Global 275
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View Lastest Price from 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid manufacturers

Wuhan Quanjinci New Material Co.,Ltd.
Product
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid 162401-62-9
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000000 tons
Release date
2023-11-07
Honest Joy Holdings Limited
Product
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid 162401-62-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99.1%
Supply Ability
100 tons
Release date
2022-02-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 162401-62-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

162401-62-9, 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acidRelated Search:

Roflumilast benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- 3-(cyclopropylMethoxy)-N-(3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzoyl)-N-(3,5-dichloropyridin-4-yl)-4-(difluoroMethoxy)benzaMide Roflumilast-d4 4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast 4-Amino-3,5-dichloropyridine RofluMilast N-Oxide RofluMilast related substance Roflumilast N-(3-Chloropyridin-4-yl)-3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzaMide 4-Amino-3,5-dichloropyridine N-oxide RofluMilast related substance 3,5-DICHLORO-4-AMINOPYRIDINE Roflumilast N-oxide D4 3-CyclopropylMethoxy-4-Hydroxybenzaldehyde 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE 3,4-BIS-DIFLUOROMETHOXY-BENZALDEHYDE

  • 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
  • 3-CyclopropyMethoxy-4-difluoroMethoxy benzoic acid
  • Benzoic acid, 3-(cyclopropylMethoxy)-4-(difluoroMethoxy)-
  • CYCLOPROPYL DIFLUOROMETHOXYBENOZOIC ACID
  • 3-CyclopropylMethoxy-4-isopropoxy-benzoic acid
  • RofluMilast InterMediate II
  • Roflumilast intermediate (3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid)
  • Roflumilast Acid Impurity
  • 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, >=98%
  • Roflumilast intermediate B
  • Roflumilast Impurity J
  • RofluM
  • Roflumilast Carboxylic Acid Impurity
  • Roflumilast Related Compound D
  • Roflumilast USP Related Compound D
  • Acid Impurity of Roflumilast
  • 162401-62-9
  • C12H12O4F2
  • Roflumilast interemdiate
  • Intermediates