3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

ChemicalBook > CAS DataBase List > 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

Product Name: 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
CAS No.: 162401-62-9
Chemical Name: 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
Synonyms: RofluM;Roflumilast Impurity J;Roflumilast Acid Impurity;Roflumilast intermediate B;RofluMilast InterMediate II;Acid Impurity of Roflumilast;Roflumilast Related Compound D;Roflumilast USP Related Compound D;Roflumilast Carboxylic Acid Impurity;CYCLOPROPYL DIFLUOROMETHOXYBENOZOIC ACID
CBNumber: CB02487690
Molecular Formula: C12H12F2O4
Formula Weight: 258.22
MOL File: 162401-62-9.mol

Less

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Property

Melting point:: 118-120℃
Boiling point:: 356.4±37.0 °C(Predicted)
Density: 1.355±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.87±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C12H12F2O4/c13-12(14)18-9-4-3-8(11(15)16)5-10(9)17-6-7-1-2-7/h3-5,7,12H,1-2,6H2,(H,15,16)
InChIKey: IGFDIFLMMLWKKY-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference: 162401-62-9

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: 2811
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2918999090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000161
Product name: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
Packaging: 1g
Price: $104
Updated: 2024/03/01

Alfa Aesar

Product number: H64098
Product name: 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98%
Packaging: 1g
Price: $62.9
Updated: 2024/03/01

Alfa Aesar

Product number: H64098
Product name: 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98%
Packaging: 5g
Price: $241
Updated: 2024/03/01

Alfa Aesar

Product number: H64098
Product name: 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98%
Packaging: 250mg
Price: $20.9
Updated: 2023/06/20

TRC

Product number: C988720
Product name: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
Packaging: 1g
Price: $70
Updated: 2021/12/16

Less

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Chemical Properties,Usage,Production

Uses

An impurity and intermediate in the preparation of selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Less

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Suppliers

Canada 1 China 253 Europe 1 India 8 Japan 1 United Kingdom 2 United States 13 Global 279

Hefei TianRui Pharmaceutical Chemistry Co., Ltd.

Tel: 0551-68933033 13956024211
Fax: 0551-68935833
Email: trchem@163.com
Country: China
ProdList: 81
Advantage: 58

Shanghai Famo Bio-chemical Technology Company Ltd.

Tel: +862136680027 15800370750
Email: sales@famobiotech.com
Country: China
ProdList: 518
Advantage: 56

Anhui Beirui Pharmaceutical Technology Co., Ltd

Tel: 0551-68665055 18130089676
Email: ahbrchem@163.com
Country: China
ProdList: 18
Advantage: 58

Wuhan Jinruo Pharmaceutical Co., LTD

Tel: 18327128451
Email: jinruoyaoye@163.com
Country: China
ProdList: 43
Advantage: 58

TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

Tel: 022-60182192,1339732154 18722583064
Fax: 86-22-60979672
Email: marketing@pharmacn.com
Country: China
ProdList: 112
Advantage: 61

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1998
Advantage: 65

ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: sales@zhiwe.net
Country: China
ProdList: 579
Advantage: 61

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6010
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44700
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9549
Advantage: 66

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 18088
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
Advantage: 52

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3296
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: +8613162137806 18575662672
Fax: 021 51613951
Email: mzeng@3wpharm.com
Country: China
ProdList: 9743
Advantage: 57

Wuhan ariel chemical Co., LTD.

Tel: 18986259541 18986259541
Fax: 027-87840182
Email: sales@3stc.com
Country: China
ProdList: 3942
Advantage: 58

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2892
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5654
Advantage: 65

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 4991
Advantage: 50

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6181
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 13901585132
Fax: +86-25-52131256
Email: 799750417@qq.com
Country: China
ProdList: 8888
Advantage: 55

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9552
Advantage: 55

shanghai cooperpharm co.,LTD .

Tel: +86-021-58975553
Fax: +86-021-58975554
Email: sales@cooperpharm.com
Country: China
ProdList: 1210
Advantage: 56

Moltt Biocem Co., Ltd.

Tel: +86-21-38682181 15900741819
Fax: +86-21-38682181
Country: China
ProdList: 282
Advantage: 55

Bsisun HK Imoprt And Export Company Limited

Tel: +86-18068513926
Fax: 0086-519-85153711
Country: China
ProdList: 1280
Advantage: 55

China Nobel Chem Co., Limited

Tel: +86(0)21 60484900
Fax: +86(0)21 60484900
Country: China
ProdList: 764
Advantage: 50

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4576
Advantage: 55

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2867
Advantage: 52

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9906
Advantage: 55

Jinan Mingya Medical Technology Co., Ltd.

Tel: 0531-85828981
Fax: +86-531-85806006
Email: 864598798@qq.com
Country: China
ProdList: 588
Advantage: 58

GIHI CHEMICALS CO.,LTD

Tel: 0086-571-86217390
Fax: 0086-571-86217391
Email: Sales@gihichem.com
Country: China
ProdList: 861
Advantage: 58

Ningbo Taikang Chemical Co., Ltd.

Tel: 0574-87365517 18074210286
Fax: 87367735
Email: sales@taikangchem.com
Country: China
ProdList: 303
Advantage: 58

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3123
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

ALPENGLOW CHEMICAL INDUSTRIAL CO., LTD

Tel: 086-0531-86986713
Fax: 086-0531-86980810
Email: aplgroup@163.com
Country: China
ProdList: 96
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13359
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15185
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9633
Advantage: 58

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4619
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4951
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10287
Advantage: 55

Shanxi Yongjin Group Co.,Ltd

Tel: 400-998-2989 13456132869
Fax: 2540941631
Email: sales@jinjingroup.com
Country: China
ProdList: 132
Advantage: 56

Changzhou Yuanda Pharmaceutical Chemical Co., Ltd.

Tel: 0519-83984084
Fax: 0519-88776993
Email: sales@ydpharm.com
Country: China
ProdList: 119
Advantage: 60

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9911
Advantage: 50

Less

View Lastest Price from 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid manufacturers

Wuhan Quanjinci New Material Co.,Ltd.

Product: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid 162401-62-9
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000000 tons
Release date: 2023-11-07

Honest Joy Holdings Limited

Product: 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid 162401-62-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.1%
Supply Ability: 100 tons
Release date: 2022-02-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 162401-62-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

162401-62-9, 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acidRelated Search:

Roflumilast benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- 3-(cyclopropylMethoxy)-N-(3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzoyl)-N-(3,5-dichloropyridin-4-yl)-4-(difluoroMethoxy)benzaMide Roflumilast-d4 4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast 4-Amino-3,5-dichloropyridine RofluMilast N-Oxide RofluMilast related substance Roflumilast N-(3-Chloropyridin-4-yl)-3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzaMide 4-Amino-3,5-dichloropyridine N-oxide RofluMilast related substance 3,5-DICHLORO-4-AMINOPYRIDINE Roflumilast N-oxide D4 3-CyclopropylMethoxy-4-Hydroxybenzaldehyde 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE 3,4-BIS-DIFLUOROMETHOXY-BENZALDEHYDE

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

3-CyclopropyMethoxy-4-difluoroMethoxy benzoic acid

Benzoic acid, 3-(cyclopropylMethoxy)-4-(difluoroMethoxy)-

CYCLOPROPYL DIFLUOROMETHOXYBENOZOIC ACID

3-CyclopropylMethoxy-4-isopropoxy-benzoic acid

RofluMilast InterMediate II

Roflumilast intermediate (3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid)

Roflumilast Acid Impurity

3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, >=98%

Roflumilast intermediate B

Roflumilast Impurity J

RofluM

Roflumilast Carboxylic Acid Impurity

Roflumilast Related Compound D

Roflumilast USP Related Compound D

Acid Impurity of Roflumilast

162401-62-9

C12H12O4F2

Roflumilast interemdiate

Intermediates