ChemicalBook > CAS DataBase List > 1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole

1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole

Uses

Product Name: 1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole
CAS No.: 882562-40-5
Chemical Name: 1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole
Synonyms: 3-(2,5-Dichloro-4-pyrimidinyl)-1-(phenylsulfonyl)-1H-indole;3-(2,5-dichloropyriMidin-4-yl)-1-(phenylsulfonyl)-1H-indole;1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole;1H-Indole, 3-(2,5-dichloro-4-pyrimidinyl)-1-(phenylsulfonyl)-
CBNumber: CB92595909
Molecular Formula: C18H11Cl2N3O2S
Formula Weight: 404.27
MOL File: 882562-40-5.mol

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1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole Property

Boiling point:: 650.4±65.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.21±0.40(Predicted)
Appearance: White to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D436805
Product name: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole
Packaging: 250mg
Price: $140
Updated: 2021/12/16

TRC

Product number: D436805
Product name: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole
Packaging: 1g
Price: $415
Updated: 2021/12/16

Matrix Scientific

Product number: 096615
Product name: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole
Purity: 95+%
Packaging: 1g
Price: $341
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0363996
Product name: 3-(2,5-DICHLOROPYRIMIDIN-4-YL)-1-(PHENYLSULFONYL)-1H-INDOLE
Purity: 95.00%
Packaging: 5MG
Price: $496.88
Updated: 2021/12/16

Matrix Scientific

Product number: 096615
Product name: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole
Purity: 95+%
Packaging: 5g
Price: $908
Updated: 2021/12/16

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1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole Chemical Properties,Usage,Production

Uses

3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole can be used to synthesize CDK or JNK inhibitors.

Uses

3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole can be used to synthesize CDK or JNK inhibitors.

Synthesis

5750-76-5

129271-98-3

882562-40-5

Under nitrogen atmosphere, 2,4,5-trichloropyrimidine (1.25 g) was dissolved in a mixed solvent of anhydrous acetonitrile/water (20 ml/10 ml), followed by the addition of 1-(phenylsulfonyl)-3-indoleboronic acid (2.0 g) and sodium carbonate (1.4 g). The reaction mixture was degassed three times, followed by the addition of tetrakis(triphenylphosphine)palladium(0) (390 mg). After degassing again three times, the mixture was heated to reflux and kept for 90 minutes. Upon completion of the reaction, the precipitate was collected by filtration and washed sequentially with water and ether to afford the target product 3-(2,5-dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole as a white solid (2.48 g, 91% yield). The product was characterized by 1H NMR (300 MHz, d6-DMSO): δ 9.00 (1H, s), 8.80 (1H, s), 8.55 (1H, d), 8.15 (2H, d), 8.05-8.02 (1H, s), 7.75 (1H, t), 7.64 (2H, t), 7.52-7.41 (2H, m).

References

[1] Patent: WO2006/38001, 2006, A1. Location in patent: Page/Page column 40
[2] Journal of the American Chemical Society, 2015, vol. 137, # 46, p. 14640 - 14652
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 12, p. 3463 - 3467

1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole Preparation Products And Raw materials

Raw materials

Preparation Products

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882562-40-5, 1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indoleRelated Search:

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882562-40-5