2-PYRIDIN-2-YL-PROPAN-2-OL

Product Name: 2-PYRIDIN-2-YL-PROPAN-2-OL
CAS No.: 37988-38-8
Chemical Name: 2-PYRIDIN-2-YL-PROPAN-2-OL
Synonyms: 2-(2-PYRIDYL)PROPAN-2-OL;2-(2-Pyridyl)-2-propanol;2-PYRIDIN-2-YL-PROPAN-2-OL;1-PYRIDYL-1,1-DIMETHYLMETHANOL;2-(2-Hydroxyprop-2-yl)pyridine;a,a-diMethyl-2-PyridineMethanol;2-Pyridinemethanol, α,α-dimethyl-;2-(PYRIDINE-2-YL)PROPAN-2-OL,MIN.95%PYALC
CBNumber: CB9260241
Molecular Formula: C8H11NO
Formula Weight: 137.18
MOL File: 37988-38-8.mol

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2-PYRIDIN-2-YL-PROPAN-2-OL Property

Melting point:: 49-50 °C
Boiling point:: 203-205 °C
Density: 1.052±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: crystal
pka: 13.61±0.29(Predicted)
color: white

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Safety

Hazard Note: Harmful
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Strem Chemicals

Product number: 07-3333
Product name: 2-(Pyridine-2-yl)propan-2-ol, min. 95% pyalc
Packaging: 100mg
Price: $58
Updated: 2024/03/01

Strem Chemicals

Product number: 07-3333
Product name: 2-(Pyridine-2-yl)propan-2-ol, min. 95% pyalc
Packaging: 500mg
Price: $227
Updated: 2024/03/01

Strem Chemicals

Product number: 07-3333
Product name: 2-(Pyridine-2-yl)propan-2-ol, min. 95% pyalc
Packaging: 2g
Price: $679
Updated: 2024/03/01

SynQuest Laboratories

Product number: 4H56-1-8A
Product name: 2-(2-Hydroxyprop-2-yl)pyridine
Packaging: 100mg
Price: $88
Updated: 2021/12/16

AK Scientific

Product number: 4873AB
Product name: 2-(Pyridin-2-yl)propan-2-ol
Packaging: 100mg
Price: $134
Updated: 2021/12/16

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2-PYRIDIN-2-YL-PROPAN-2-OL Chemical Properties,Usage,Production

Synthesis

91-02-1

917-54-4

37988-38-8

19490-92-7

Example 8. Synthesis of 2-(pyridin-2-yl)propan-2-ol (PyPrOH) and 1-phenyl-1-(pyridin-2-yl)ethanol (PPE). 2-Benzoylpyridine (8.3 mmol) was dissolved in dry ether (100 mL) in a 250 mL Schlenk flask that was pre-oven dried. The reaction system was cooled to -78°C, followed by the slow addition of methyl lithium (12.9 mL, 1.6 M ether solution) over 15 min. The resulting yellow solution was stirred at -78°C for 1 hour and then slowly warmed to room temperature. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous ammonium chloride solution (30 mL) and the mixture was extracted with ethyl acetate (3 x 75 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (silica gel, eluent ratio: 1:1 ethyl acetate/dichloromethane for PyPrOH, 1:3 ethyl acetate/dichloromethane for PPE) to give a light yellow, oily target product. 55% yield of PyPrOH was obtained.PyPrOH NMR Hydrogen spectrum (CDCl3, 300 MHz): δ 8.52 (d, J = 4.8 Hz , 1H), 7.71 (t, J = 7.8 Hz, 1H), 7.38 (d, J = 8.1 Hz, 1H), 7.21 (t, J = 6.2 Hz, 1H), 5.08 (s, 1H), 1.54 (s, 6H). 97% yield of PPE. NMR hydrogen spectrum of PPE (CDCl3, 300 MHz): δ 8.52 (m, 1H), 7.65 (td, J = 4.8 Hz), 1.54 (s, 6H). 7.65 (td, J = 7.8, 1.8 Hz, 1H), 7.48 (m, 2H), 7.31 (m, 3H), 7.17-7.26 (m, 2H), 5.85 (s, 1H), 1.94 (s, 3H).

References

[1] Patent: WO2014/200497, 2014, A1. Location in patent: Paragraph 00151

2-PYRIDIN-2-YL-PROPAN-2-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PYRIDIN-2-YL-PROPAN-2-OL Suppliers

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37988-38-8, 2-PYRIDIN-2-YL-PROPAN-2-OLRelated Search:

Doxylamine succinate DOXYLAMINE Pyrinoline NORBORMIDE 3-PYRIDIN-3-YL-PROPAN-1-OL 3-PYRIDIN-4-YL-PROPAN-1-OL 2-(Pyridin-3-yl)propan-2-ol 2-PYRIDIN-2-YL-PROPAN-2-OL 1-PHENYL-1-(2-PYRIDYL)ETHANOL Pyridinemethanol, alpha-(p-chlorophenyl)-alpha-(dimethylaminoethyl)-, hydrochloride PYRIDINE-2-YL DIPHENYLMETHANOL QUINOLINE-2-YL DIPHENYL METHANOL 3-AMINO-3-PYRIDIN-3-YL-PROPAN-1-OL 2-(Pyridin-4-yl)propan-2-ol 2-(8-Fluoro-imidazo[1,2-a]pyridin-7-yl)-propan-2-ol 3-(2-METHYL-PYRIDIN-4-YL)-PROPAN-1-OL 2-(6-(trifluoromethyl)pyridin-3-yl)propan-2-ol 2,2,3,3,3-PENTAFLUORO-1-PYRIDIN-3-YL-PROPAN-1-OL

1-PYRIDYL-1,1-DIMETHYLMETHANOL

2-(2-PYRIDYL)PROPAN-2-OL

2-PYRIDIN-2-YL-PROPAN-2-OL

a,a-diMethyl-2-PyridineMethanol

2-(2-Hydroxyprop-2-yl)pyridine

2-(PYRIDINE-2-YL)PROPAN-2-OL,MIN.95%PYALC

2-(2-Pyridyl)-2-propanol

2-Pyridinemethanol, α,α-dimethyl-

37988-38-8