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MMP-13 Inhibitor

Product Name
MMP-13 Inhibitor
CAS No.
544678-85-5
Chemical Name
MMP-13 Inhibitor
Synonyms
DB04760;MMP-13 Inhibitor;DB04760 (DB 04760);DB04760 (COMPOUND 4);MMP-13 Inhibitor inhibitor;N,N'-Bis[(4-fluoro-3-methylphenyl)methyl]-4,6-pyrimidinedicarboxamide;4,6-Pyrimidinedicarboxamide, N4,N6-bis[(4-fluoro-3-methylphenyl)methyl]-;N4,N6-Bis(4-fluoro-3-Methylbenzyl)pyriMidine-4,6-dicarboxaMide
CBNumber
CB92602854
Molecular Formula
C22H20F2N4O2
Formula Weight
410.42
MOL File
544678-85-5.mol
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MMP-13 Inhibitor Property

Boiling point:
684.6±55.0 °C(Predicted)
Density 
1.286±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
≤0.5mg/ml in ethanol;2mg/ml in DMSO;2mg/ml in dimethyl formamide
pka
11.79±0.46(Predicted)
form 
Light yellow crystalline solid.
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Safety

HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19540
Product name
MMP-13 Inhibitor
Purity
≥98%
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
19540
Product name
MMP-13 Inhibitor
Purity
≥98%
Packaging
5mg
Price
$355
Updated
2024/03/01
Cayman Chemical
Product number
19540
Product name
MMP-13 Inhibitor
Purity
≥98%
Packaging
10mg
Price
$601
Updated
2024/03/01
ApexBio Technology
Product number
C4331
Product name
MMP-13Inhibitor
Packaging
10mg
Price
$686
Updated
2021/12/16
AK Scientific
Product number
Z3393
Product name
Pyrimidine-4,6-dicarboxylicacidbis-(4-fluoro-3-methyl-benzylamide)
Packaging
10mg
Price
$768
Updated
2021/12/16
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MMP-13 Inhibitor Chemical Properties,Usage,Production

Description

MMP-13 Inhibitor is a pyrimidine dicarboxamide that inhibits matrix metalloproteinase-13 (MMP-13, also known as collagenase-3) with an IC50 value of 8 nM. MMP-13 Inhibitor binds to pockets that are unique to MMP-13, rather than the catalytic zinc, and thus is specific for MMP-13 over other MMPs. MMP-13 Inhibitor blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification.

Chemical Properties

White crystal

in vitro

mmp-13 inhibitor was previously synthesized as a pyrimidine dicarboxamide that could inhibit the matrix metalloproteinase-13 (mmp-13) with the ic50 of 8 nm. moreover, mmp-13 inhibitor was found to be able to bind to mmp pockets that are unique to mmp-13 rather than the catalytic zinc, and therefore was specific for mmp-13 over other mmps. in addition, during endochondral ossification, mmp-13 inhibitor could also block osterix-dependent calcification of matrices in limb bud cells [1, 2, 3].

IC 50

8 nm

References

1. carrascal, n.a. and rizzo, r.c. calculation of binding free energies for non-zinc chelating pyrimidine dicarboxamide inhibitors with mmp-13. bioorg.med.chem.lett. 19(1), (2009).2. engel, c.k.,pirard, b.,schimanski, s., et al. structural basis for the highly selective inhibition of mmp-13. chem.biol. 12(2), 181-189 (2005).3. nishimura, r.,wakabayashi, m.,hata, k., et al. osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (mmp13) expression in association with transcription factor runx2 during endochondral ossification. j.biol.chem. 287(40), 33179-33190 (2012).

MMP-13 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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MMP-13 Inhibitor Suppliers

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544678-85-5, MMP-13 InhibitorRelated Search:

p-Toluidine 2-Methylindole α-Bromo-2,3,4,5,6-pentafluorotoluene Benzylacetone Tetramethylammonium chloride

  • MMP-13 Inhibitor
  • N<sup>4</sup>,N<sup>6</sup>-Bis(4-fluoro-3-Methylbenzyl)pyriMidine-4,6-dicarboxaMide
  • N,N'-Bis[(4-fluoro-3-methylphenyl)methyl]-4,6-pyrimidinedicarboxamide
  • DB04760 (COMPOUND 4)
  • DB04760
  • DB04760 (DB 04760)
  • 4,6-Pyrimidinedicarboxamide, N4,N6-bis[(4-fluoro-3-methylphenyl)methyl]-
  • MMP-13 Inhibitor inhibitor
  • 544678-85-5
  • C22H20F2N4O2